Natural Products Repertoire of the Red Sea

El‐Hossary, Ebaa M.; Abdel‐Halim, Mohammad; Ibrahim, Eslam S.; Pimentel‐Elardo, Sheila Marie; Nodwell, Justin R.; Handoussa, Heba; Abdelwahab, Miada F.; Holzgrabe, Ulrike; Abdelmohsen, Usama Ramadan

doi:10.3390/md18090457

Cited by 26 publications

(19 citation statements)

References 124 publications

(237 reference statements)

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“…From coral-associated organisms, 300 biologically active substances with cytotoxic, antiparasitic, antibacterial, antiinflammatory activities have been isolated (Hou et al, 2019). These compounds are studied as potential anti-tumour and antiviral preparations, including against SARS-CoV-2 and HIV (El-Hossary et al, 2020;Zahran et al, 2020). Many bioactive products (terpenoids, sesquiterpenes, diterpe-nes, steroids and many other) are produced by soft corals and are promising objects for the development of various pharmaceutical preparations (Sang et al, 2019).…”

Section: Marine Organisms Producing Cytotoxic Compoundsmentioning

confidence: 99%

Anti-tumour drugs of marine origin currently at various stages of clinical trials (review)

Bocharova

Копытина

Slynko

2021

Regul. Mech. Biosyst.

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Oncological diseases for a long time have remained one of the most significant health problems of modern society, which causes great losses in its labour and vital potential. Contemporary oncology still faces unsolved issues as insufficient efficacy of treatment of progressing and metastatic cancer, chemoresistance, and side-effects of the traditional therapy which lead to disabilities among or death of a high number of patients. Development of new anti-tumour preparations with a broad range of pharmaceutical properties and low toxicity is becoming increasingly relevant every year. The objective of the study was to provide a review of the recent data about anti-tumour preparations of marine origin currently being at various phases of clinical trials in order to present the biological value of marine organisms – producers of cytotoxic compounds, and the perspectives of their use in modern biomedical technologies. Unlike the synthetic oncological preparations, natural compounds are safer, have broader range of cytotoxic activity, can inhibit the processes of tumour development and metastasis, and at the same time have effects on several etiopathogenic links of carcinogenesis. Currently, practical oncology uses 12 anti-tumour preparations of marine origin (Fludarabine, Cytarabine, Midostaurin, Nelarabine, Eribulin mesylate, Brentuximab vedotin, Trabectedin, Plitidepsin, Enfortumab vedotin, Polatuzumab vedotin, Belantamab mafodotin, Lurbinectedin), 27 substances are at different stages of clinical trials. Contemporary approaches to the treatment of oncological diseases are based on targeted methods such as immune and genetic therapies, antibody-drug conjugates, nanoparticles of biopolymers, and metals. All those methods employ bioactive compounds of marine origin. Numerous literature data from recent years indicate heightened attention to the marine pharmacology and the high potential of marine organisms for the biomedicinal and pharmaceutic industries.

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Section: Marine Organisms Producing Cytotoxic Compoundsmentioning

confidence: 99%

Anti-tumour drugs of marine origin currently at various stages of clinical trials (review)

Bocharova

Копытина

Slynko

2021

Regul. Mech. Biosyst.

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“…In the recent couple of decades, intensive drug discovery research shed the light on the Red Sea marine invertebrates and its bioactive compositions. Several bioactive metabolites with unique chemical scaffolds were isolated, identified and showed promising pharmacological activities from the Red Sea marine life (El-Hossary et al, 2020). Biological activity herein is referred to in case of on any early experimental to late clinical evidence for potential use in the treatment of any human disease.…”

Section: Rationalementioning

confidence: 99%

Bioactive marine metabolites derived from the Persian Gulf compared to the Red Sea: similar environments and wide gap in drug discovery

Abuhijjleh

Shabbir

Al‐Abd

et al. 2021

PeerJ

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Marine life has provided mankind with unique and extraordinary chemical structures and scaffolds with potent biological activities. Many organisms and secondary metabolites derived from fungi and symbionts are found to be more environmentally friendly to study than the marine corals per se. Marine symbionts such as Aspergillus sp., a fungus, which can be isolated and grown in the lab would be a potential and continuous source of bioactive natural compounds without affecting the marine environment. The Red Sea is known for its biodiversity and is well-studied in terms of its marine-derived bioactive metabolites. The harsh environmental conditions lead to the development of unique metabolic pathways. This, in turn, results in enhanced synthesis and release of toxic and bioactive chemicals. Interestingly, the Persian Gulf and the Gulf of Oman carry a variety of environmental stresses, some of which are similar to the Red Sea. When compared to the Red Sea, the Persian Gulf has been shown to be rich in marine fungi as well, and is, therefore, expected to contain elaborate and interesting bioactive compounds. Such compounds may or may not be similar to the ones isolated from the Red Sea environment. Astoundingly, there are a very limited number of studies on the bioactive portfolio of marine-derived metabolites from the Persian Gulf and the Gulf of Oman. In this perspective, we are looking at the Red Sea as a comparator marine environment and bioactive materials repertoire to provide a futuristic perspective on the potential of the understudied and possibly overlooked bioactive metabolites derived from the marine life of the Persian Gulf and the Gulf of Oman despite its proven biodiversity and harsher environmental stress.

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“…In addition, polyP has been shown to have synergistic anti-viral effects in combination with the anti-inflammatory agent dexamethasone or the anti-oxidant compound quercetin. Furthermore, many studies have shown that several marine metabolites isolated from scleractinia related organisms, sponges and algae can interact with the main protease of Sars-CoV-2, M pro [ 13 , 14 , 15 , 26 , 27 , 28 ]. M pro is a crucial protein enzyme of the virus and has a critical role in mediating the replication and transcription of the viral particles, making it a potential drug target against the virus [ 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

The Anti-Viral Applications of Marine Resources for COVID-19 Treatment: An Overview

2021

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The ongoing pandemic has led to an urgent need for novel drug discovery and potential therapeutics for Sars-CoV-2 infected patients. Although Remdesivir and the anti-inflammatory agent dexamethasone are currently on the market for treatment, Remdesivir lacks full efficacy and thus, more drugs are needed. This review was conducted through literature search of PubMed, MDPI, Google Scholar and Scopus. Upon review of existing literature, it is evident that marine organisms harbor numerous active metabolites with anti-viral properties that serve as potential leads for COVID-19 therapy. Inorganic polyphosphates (polyP) naturally found in marine bacteria and sponges have been shown to prevent viral entry, induce the innate immune response, and downregulate human ACE-2. Furthermore, several marine metabolites isolated from diverse sponges and algae have been shown to inhibit main protease (Mpro), a crucial protein required for the viral life cycle. Sulfated polysaccharides have also been shown to have potent anti-viral effects due to their anionic properties and high molecular weight. Likewise, select marine sponges produce bromotyrosines which have been shown to prevent viral entry, replication and protein synthesis. The numerous compounds isolated from marine resources demonstrate significant potential against COVID-19. The present review for the first time highlights marine bioactive compounds, their sources, and their anti-viral mechanisms of action, with a focus on potential COVID-19 treatment.

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Natural Products Repertoire of the Red Sea

Cited by 26 publications

References 124 publications

Anti-tumour drugs of marine origin currently at various stages of clinical trials (review)

Anti-tumour drugs of marine origin currently at various stages of clinical trials (review)

Bioactive marine metabolites derived from the Persian Gulf compared to the Red Sea: similar environments and wide gap in drug discovery

The Anti-Viral Applications of Marine Resources for COVID-19 Treatment: An Overview

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