Natural products utilization

Georgiev, Milen I.

doi:10.1007/s11101-014-9363-3

Cited by 20 publications

(14 citation statements)

References 14 publications

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“…To this end, it is mandatory to improve our knowledge on the mechanism(s) of ACR toxicity at cellular and molecular levels in the various organs. The Food and Agricultural Organization estimates that the world population by the year 2050 will be increased by a third (Alexandratos and Bruinsma, 2012), and one of the recognized challenges that men will have to face is the requirement of more medicines to eradicate human health challenges (Georgiev, 2014). Because many plant species and products obtained from them have provided positive responses towards human health disorders, especially as they have been discussed here, and ACR toxicity is not an issue to be overlooked, further intense and molecular studies on the plants here reported and others should be pursued.…”

Section: Resultsmentioning

confidence: 99%

The Potential for Plant Derivatives against Acrylamide Neurotoxicity

Adewale

Brimson

Odunola

et al. 2015

Phytotherapy Research

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Certain industrial chemicals and food contaminants have been demonstrated to possess neurotoxic activity and have been suspected to cause brain-related disorders in humans. Acrylamide (ACR), a confirmed neurotoxicant, can be found in trace amount in commonly consumed human aliments as a result of food processing or cooking. This discovery aroused a great concern in the public, and increasing efforts are continuously geared towards the resolution of this serious threat. The broad chemical diversity of plants may offer the resources for novel antidotes against neurotoxicants. With the goal of attenuating neurotoxicity of ACR, several plants extracts or derivatives have been employed. This review presents the plants and their derivatives that have been shown most active against ACR-induced neurotoxicity, with a focus on their origin, pharmacological activity, and antidote effects.

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Section: Resultsmentioning

confidence: 99%

The Potential for Plant Derivatives against Acrylamide Neurotoxicity

Adewale

Brimson

Odunola

et al. 2015

Phytotherapy Research

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“…Natural products and, more specifically, medicinal plant species have been utilized for centuries in the treatment and management of various pathological conditions (Georgiev, 2014). Stress-induced disorders are characterized by changes in the CNS that involve a plethora of molecular pathways, suggesting that the therapy against such multifactorial conditions should target more than one neuroendocrine system.…”

Section: Plant Extracts and Their Bioactive Molecules With Effect On mentioning

confidence: 99%

Immunoregulatory natural compounds in stress-induced depression: An alternative or an adjunct to conventional antidepressant therapy?

Vasileva

Ivanovska

Murdjeva

et al. 2019

Food and Chemical Toxicology

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The interplay of chronic stress, neuroinflammation and altered immune reactivity has been shown to be important for the pathophysiology of brain disorders such as schizophrenia, depressive disorders and post-traumatic stress disorder. This immuno-inflammatory theory has been extensively studied in the past three decades leading to the formation of the integrative discipline of psychoneuroimmunology. Targeting of the central nervous system by conventional pharmacotherapeutic methods is mainly through modulation of neuroendocrine systems such as the dopaminergic, GABA-ergic, adrenergic and serotoninergic systems. In recent years an increasing number of both experimental and clinical studies have shown that antidepressants can affect the immune system by reducing the production of pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α. However, due to the serious adverse effects accompanying the chronic administration of psychoactive drugs there is a continuous need to produce novel therapeutics that are both potent and safe. The present review aims to summarize the current knowledge in the field of psychoneuroimmunology and to delineate the main interactions between stress, inflammation, immunity and the brain. Additionally, this paper explores the use of plant-derived molecules that display a strong anti-stress effect and simultaneously modulate the immune response as an alternative or adjuvant to classical antidepressant drugs.

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“…Moreover, the relatively low incidence of side effects and the possibility of prolonged use of plant origin substances based medicine contributes not only to the search for new sources, but also to the improvement of methods for extraction of biologically active substances from plant materials. [2,3]. The efficiency of the extraction process is influenced by various factors common to the extraction processes as a whole: the nature of the plant material, temperature, the degree of grinding of the plant material, the nature of mixing, the time of extraction, the renewal of the extractant during the extraction process [4].…”

Section: Introductionmentioning

confidence: 99%