Natural Protection Against Cardiac Arrhythmias During Hibernation: Significance of Adenosine

Jinka, Tulasi R.

doi:10.5772/34333

Cited by 2 publications

(1 citation statement)

References 83 publications

(137 reference statements)

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“…In contrast, inhibition of A 1 Rs counteracted BAT thermogenesis induced by intracerebroventricular injection of CHA (Tupone et al, 2013). In addition to inhibiting BAT thermogenesis, activation of A 1 Rs in the NTS increases vasopressin secretion, which constricts blood vessels, including skin vessels, thereby increasing arterial blood pressure (McClure et al, 2005;McClure et al, 2011) and causing bradycardia, one of the initial physiological features of natural hibernation (Jinka, 2012). The rPA, the median preoptic area (MnPO) and the supraoptic nucleus (SON) also appear to mediate the effect of A 1 Rs in BAT thermogenic, as the rPA and MnPO c-fos expression is lower in winter than in summer after CHA administration, and inhibition of rPA neurons produces hypothermia, however the SON is related to the seasonal increase in vasoconstriction (Cerri et al, 2013;Frare et al, 2019).…”

Section: Central Activation Of a 1 Rs Is Sufficient To Induce And Mai...mentioning

confidence: 99%

Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

Yuan

Zhang

et al. 2023

Front. Pharmacol.

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Graphical AbstractAdenosine mediates sleep, torpor and hibernation through P1 receptors. Recent reasearch has shown that P1 receptors play a vital role in the regulation of sleep-wake, torpor and hibernation-like states. In this review, we focus on the roles and neurobiological mechanisms of the CNS adenosine and P1 receptors in these three states. Among them, A1 and A2A receptors are key targets for sleep-wake regulation, A1Rs and A3Rs are very important for torpor induction, and activation of A1Rs is sufficient for hibernation-like state.

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Section: Central Activation Of a 1 Rs Is Sufficient To Induce And Mai...mentioning

confidence: 99%

Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

Yuan

Zhang

et al. 2023

Front. Pharmacol.

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Central Activation of the A1 Adenosine Receptor (A1AR) Induces a Hypothermic, Torpor-Like State in the Rat

2013

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Since central activation of A1 adenosine receptors (A1ARs) plays an important role in the induction of the hypothermic and hypometabolic torpid state in hibernating mammals, we investigated the potential for the A1AR agonist N6-cyclohexyladenosine to induce a hypothermic, torpor-like state in the (nonhibernating) rat. Core and brown adipose tissue temperatures, EEG, heart rate, and arterial pressure were recorded in free-behaving rats, and c-fos expression in the brain was analyzed, following central administration of N6-cyclohexyladenosine. Additionally, we recorded the sympathetic nerve activity to brown adipose tissue; expiratory CO 2 and skin, core, and brown adipose tissue temperatures; and shivering EMGs in anesthetized rats following central and localized, nucleus of the solitary tract, administration of N6-cyclohexyladenosine. In rats exposed to a cool (15°C) ambient temperature, central A1AR stimulation produced a torpor-like state similar to that in hibernating species and characterized by a marked fall in body temperature due to an inhibition of brown adipose tissue and shivering thermogenesis that is mediated by neurons in the nucleus of the solitary tract. During the induced hypothermia, EEG amplitude and heart rate were markedly reduced. Skipped heartbeats and transient bradycardias occurring during the hypothermia were vagally mediated since they were eliminated by systemic muscarinic receptor blockade. These findings demonstrate that a deeply hypothermic, torpor-like state can be pharmacologically induced in a nonhibernating mammal and that recovery of normothermic homeostasis ensues upon rewarming. These results support the potential for central activation of A1ARs to be used in the induction of a hypothermic, therapeutically beneficial state in humans.

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Natural Protection Against Cardiac Arrhythmias During Hibernation: Significance of Adenosine

Cited by 2 publications

References 83 publications

Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation

Central Activation of the A1 Adenosine Receptor (A1AR) Induces a Hypothermic, Torpor-Like State in the Rat

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