Natural protein-based electrospun nanofibers for advanced healthcare applications: progress and challenges

Agarwal, Anushka; Rao, Gyaneshwar K.; Majumder, Sudip; Shandilya, Manish; Rawat, Varun; Purwar, Roli; Verma, Monu; Srivastava, Chitra

doi:10.1007/s13205-022-03152-z

Cited by 8 publications

(2 citation statements)

References 197 publications

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“…Various parameters such as flow rate, concentration, voltage, tip-collector distance (TCD), molecular weight, viscosity, surface tension, and conductivity together determine the morphology and properties of electrospun fibers [15].…”

Section: Electrospinningmentioning

confidence: 99%

Nanofibers produced from medicinal and aromatic plant extracts by electrospinning method

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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Electrospinning (ES) is a fiber fabrication technology that uses electrical force with polymer solutions or polymer melts. ES is a flexible and economical technique for producing continuous nanoand microfiber membranes with tunable structures, properties, and functionalities. Since 2000, there have been significant advances in the field of electrospinning. ES has proven to be the most cost-effective, simple, and reliable method for producing nanofibers. ES is a carrier system that can be used for these purposes and is a suitable platform for the production of new materials. Many research studies have been conducted using both natural and synthetic polymers. In the ES process, bioactive chemicals are incorporated into polymers because of many advantages. Plant extracts are a storehouse of bioactive chemicals with medicinal applications. These medicinal and beneficial properties of plants can be transferred to nanofibers. Nanofibers are a subset of nanostructures. One of the most efficient methods to produce nanofibers is electrospinning. The aim of this review is to present a summary of some recent studies in which crude plant extracts have been loaded with various natural or synthetic polymers for applications.

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Section: Electrospinningmentioning

confidence: 99%

Nanofibers produced from medicinal and aromatic plant extracts by electrospinning method

2023

Proceeding Book of 3rd International Conference on Scientific and Academic Research ICSAR 2023

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“…An important advantage of electrospinning is that the morphology, internal structure, sizes, architectures, and surface properties are tunable and controllable, making this technique eligible for various investigations and applications in the biomedical field. Owing to these suitable characteristics, electrospinning has shown a great potential to obtain products with improved and innovative facilities in tissue engineering [ 18 , 19 , 20 , 21 , 22 ], wound dressings [ 23 , 24 , 25 , 26 ], drug delivery systems [ 19 , 27 , 28 , 29 , 30 , 31 ], biosensors [ 30 , 32 , 33 ], healthcare products [ 34 , 35 , 36 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Stoica

Albuleț

Bîrcă

et al. 2023

IJMS

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Injuries and diseases of the skin require accurate treatment using nontoxic and noninvasive biomaterials, which aim to mimic the natural structures of the body. There is a strong need to develop biodevices capable of accommodating nutrients and bioactive molecules and generating the process of vascularization. Electrospinning is a robust technique, as it can form fibrous structures for tissue engineering and wound dressings. The best way of forming such meshes for wound healing is to choose two polymers that complement each other regarding their properties. On the one hand, PVA is a water-soluble synthetic polymer widely used for the preparation of hydrogels in the field of biomedicine owing to its biocompatibility, water solubility, nontoxicity, and considerable mechanical properties. PVA is easy to subject to electrospinning and can offer strong mechanical stability of the mesh, but it is necessary to improve its biological properties. On the other hand, CS has good biological properties, including biodegradability, nontoxicity, biocompatibility, and antimicrobial properties. Still, it is harder to electrospin and does not possess as good mechanical properties as PVA. As these structures also allow the incorporation of bioactive agents due to their high surface-area-to-volume ratio, the interesting point was to incorporate usnic acid into the structure as it is a natural and suitable alternative agent for burn wounds treatment which avoids an improper or overuse of antibiotics and other invasive biomolecules. Thus, we report the fabrication of an electrospun nanofibrous mesh based on PVA, chitosan, and usnic acid with applications in wound healing. The obtained nanofibers mesh was physicochemically characterized by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). In vitro biological assays were performed to evaluate the antimicrobial properties of the samples using the MIC (minimum inhibitory concentration) assay and evaluating the influence of fabricated meshes on the Staphylococcus aureus biofilm development, as well as their biocompatibility (demonstrated by fluorescence microscopy results, an XTT assay, and a glutathione (GSH) assay).

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Production of anti-inflammatory films based on cashew gum polysaccharide and polyvinyl alcohol for wound dressing applications

et al. 2023

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Natural protein-based electrospun nanofibers for advanced healthcare applications: progress and challenges

Cited by 8 publications

References 197 publications

Nanofibers produced from medicinal and aromatic plant extracts by electrospinning method

Nanofibers produced from medicinal and aromatic plant extracts by electrospinning method

Electrospun Nanofibrous Mesh Based on PVA, Chitosan, and Usnic Acid for Applications in Wound Healing

Production of anti-inflammatory films based on cashew gum polysaccharide and polyvinyl alcohol for wound dressing applications

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