The current contribution goal is to measure the distribution of the radionuclide within the exposed rock units of southwestern Sinai, Seih-Sidri area, and assess the radiological risk. Gneisses, older granites, younger gabbro, younger granites, and post granitic dikes (pegmatites) are the main rock units copout in the target area. Radioactivity, as well as radiological implications, were investigated for forty-three samples from gneisses (seven hornblende biotite gneiss and seven biotite gneiss), older granites (fourteen samples), and younger granites (fifteen samples of syenogranites) using NaI (Tl) scintillation detector. External and internal hazard index (Hex, Hin), internal and external level indices (Iα, Iγ), absorbed dose rates in the air (D), the annual effective dose equivalent (AED), radium equivalent activity (Raeq), annual gonadal dose (AGDE), excess lifetime cancer risk (ELCR), and the value of Upper Continental Core 232Th/238U mass fractions were determined from the obtained values of 238U, 232Th and 40K for the examined rocks of Seih-Sidri area. The average 238U mg/kg in hornblende biotite gneiss and biotite gneiss, older granites, and syenogranites is 2.3, 2.1, 2.7, and 8.4 mg/kg, respectively, reflecting a relatively higher concentration of uranium content in syenogranites. The results suggest that using these materials may pose risks to one’s radiological health.