Natural remedies for hyperlipidemia: A review

Dasgupta, Debankini; Bandyopadhyay, Shwetlana; Sarkar, Nandini; Chakraborty, Mousumi

doi:10.22271/phyto.2021.v10.i5c.14194

Cited by 4 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural treatments for hyperlipidemia: According to a review, the extract from Mangifera indica leaves acts to increase the expression of hepatic LDL receptors, protect against LDL-C (Low-Density Lipoprotein) buildup in the blood, and catabolize cholesterol from the body's LDL receptors (Dasgupta et al, 2021). (Arulmozhi et al, 2007) discovered that Myristica fragrans extract effectively decreased the raised TG (47% reduction at 450 mg, P<0.01) and cholesterol (66.7% reduction at 450 mg, P<0.01) in rats fed a high-cholesterol diet.…”

Section: Discussionmentioning

confidence: 99%

Clinical Effect of Poly Herbal Unani Formulation on Dyslipidemia- A Randomized Trial

Alam,

Sheikh,

Samad

2023

Turkish JAF Sci.Tech.

View full text Add to dashboard Cite

Background: In adults aged 30-70 with primary and moderate hyperlipidemia, the present study took place to investigate the therapeutic benefits of a polyherbal unani preparation called Garlitab. Methods: It was a prospective open label, herbal coded test drug-controlled, randomized trial. Out of total screened patients we were enrolled 212 hyperlipidemic patients of 30–70 years in the study fulfilling the inclusion criteria, we were recruited them from OPD of a hospital in Munshiganj and different Unani clinics of Dhaka, Bangladesh after obtaining written informed consent from the patients. Selected individuals were allocated into two groups at random. Group1 Received 500 mg Garlitab tablets twice daily and Group 2 received tablet atorvastatin calcium 10 mg 2 times daily. Height, weight, and blood pressure were recorded along with blood samples. The random distributions were carried out by a research assistant utilizing a random numbers table. Blood samples were taken at the beginning of the trial, 1.5 months later, and 3 months following the intervention. Results: Results for the test medication revealed a substantial drop in cholesterol levels between baseline and the data collected after three months and in case of male it was from 241.72±38.11 to 218.24±34.06 mg/dL for total cholesterol, from 198.27±30.57 to 173.54±29.34 mg/dL for LDL and from 280.78±85.81 to 207.07±51.40 mg/dL for triglyceride. HDL increases from 33.05±3.21 to 34.69±3.13 mg/dL in male patients. The control drug atorvastatin calcium also showed a significant decrease in lipids between baseline and after 3 months data and in case of male it was from 241.92±31.54 to 174.90±22.87 mg/dL for total cholesterol, from 196.20±30.91 to 130.30±24.29 mg/dL for LDL and from 279.48±115.35 to 141.27±59.55 mg/dL for triglyceride. It increases HDL from 32.00±2.25 to 34.03±2.19 mg/dL in male patients. Between the baseline and the 3-month data, the test medicine for females significantly reduced total cholesterol, LDL, and triglycerides and it was from 244.64±52.18 to 220.12±45.07 mg/dL, from 200.32±30.57 to 173.54±29.34 mg/dL and from 272.32±99.69 to 195.25±60.68 mg/dL respectively. HDL increases from 33.77±3.36 to 35.03±3.23 mg/dL. Between the baseline and the 3-month data, the control medication for females significantly reduced total cholesterol, LDL, and triglycerides and it was from 247.74±37.95 to 175.26±29.54 mg/dL, from 197.65±27.89 to 130.91±22.04 mg/dL and from 271.57±94.52 to 142.00±50.88 mg/dL respectively. It increases HDL from 32.22±2.32 to 33.46±2.94 mg/dL. Conclusions: According to the results of the study, the polyherbal formulation Garlitab can lower cholesterol levels. It may be a useful medication for treating primary hyperlipidemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Effect of Poly Herbal Unani Formulation on Dyslipidemia- A Randomized Trial

Alam,

Sheikh,

Samad

2023

Turkish JAF Sci.Tech.

View full text Add to dashboard Cite

show abstract

A double‐blind, randomized control trial to investigate the therapeutic potential of garlic scapes for high apoprotein E levels in a high‐Fat diet‐induced hypercholesteremic rat model

Itrat,

Nisa,

Al‐Asmari

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

Hypercholesteremia is the main contributor to metabolic diseases, including obesity, hypertension, and diabetes, which are the primary global sources of morbidity and death rates. Garlic scapes, a member of the Allium sativum family and a rich source of antioxidants, are utilized in various cuisine preparations due to their unique flavors and tastes. The current study examined garlic scape powder's effect on apoprotein E and its ability to decrease cholesterol. In an in vivo experiment, normal, healthy Wistar albino rats (weeks) were divided into a negative control group (NC, n = 10) and a high‐fat diet‐raised group (n = 50) until they achieved cholesterol ≥250 mg/dL. Hypercholesteremic rats were further divided randomly into five groups: positive control (PC), standard group (fenofibrate 20 mg/kg bwt), and treatment groups G1, G2, and G3 that were administered with garlic scape powder 400 mg, 800 mg, and 1200 mg/kg bwt orally, respectively, for 3 months. The blood samples were examined for cholesterol, triglycerides, high‐density lipoproteins (HDLs), low‐density lipoproteins, apoprotein E, albumin levels, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). The liver tissues of the rats were subjected to histopathology. The lipid profile was assessed using serum kit techniques, whereas an ELISA kit was used to evaluate apoprotein E, and a serum kit was used to estimate ALT and AST. In comparison to all other groups except NC, the highest dose of 1200 mg/kg bwt of garlic scapes significantly (p ≤ .05) increased serum insulin (13.66 ± 0.72 μU/mL), apoprotein E levels (6.08 ± 0.10 mg/dL), HDL (42.1 ± 1.81 mg/dL), and reduce TG (88.7 ± 1.64 mg/dL) and decreased overall cholesterol levels (67.9 ± 1.17 mg/dL). Except for NC, all treatment groups had significantly (p ≤ .05) lower ALT and AST values than PC. To sum up, powdered garlic scapes may be a great way to avoid hyperlipidemia, which raises the risk of cardiovascular illnesses. ALT and AST levels were significantly (p ≤ .05) reduced in all treatment groups compared to PC, except for NC. In conclusion, garlic scape powder may be an excellent source to prevent hyperlipidemia, a risk factor for cardiovascular diseases. In addition, powdered garlic scapes supplementation at high doses may be used as an alternative natural source in functional foods to halt hyperlipidemia without liver toxicity in the long term.

show abstract

Development of a zebrafish model for toxicity evaluation of adulterated Apis mellifera honey

Fakhlaei,

Selamat,

Abdull Razis

et al. 2024

Chemosphere

View full text Add to dashboard Cite

Natural remedies for hyperlipidemia: A review

Cited by 4 publications

References 41 publications

Clinical Effect of Poly Herbal Unani Formulation on Dyslipidemia- A Randomized Trial

Clinical Effect of Poly Herbal Unani Formulation on Dyslipidemia- A Randomized Trial

A double‐blind, randomized control trial to investigate the therapeutic potential of garlic scapes for high apoprotein E levels in a high‐Fat diet‐induced hypercholesteremic rat model

Development of a zebrafish model for toxicity evaluation of adulterated Apis mellifera honey

Contact Info

Product

Resources

About