Percutaneous chemical ablation (PCA)
is the oldest and most established
technique for treating small solid tumors in organs. It has been widely
used in clinics even on an outpatient basis. However, compared with
the emerging microwave or magnetic hyperthermal ablation, PCA is faced
with relatively poor necrosis results and needs to repeat multiple
sessions. Inspired by the three effects in the bomb’s explosive
process, we herein expect to combine calcium carbide (CaC2) nanoparticles into the PCA technique to generate local explosion
within tumor tissues, leading to three killing effects against tumors
to further improve the ablation efficacy of PCA. Through an efficient
wet milling procedure with poly(ethylene glycol), three kinds of nanobombs
including CaC2, calcium oxide (CaO), and calcium hydroxide
(Ca(OH)2) were fabricated, and they all exhibited desirable
suspension stability. Among these nanobombs, in particular CaC2 nanobombs showed
a synergistic effect that the generation of ethyne gas bubbles could
facilitate the most rapid diffusion of hyperthermia. Also, CaC2 nanobombs offered the powerful ability to cause the sudden
rise of local high temperature and pH value. According to the in vivo mice tumor excision trial, the tumors of 75% of
cases that received CaC2 treatment were destroyed and eradicated,
exhibiting the excellent ablation ability of CaC2 nanobombs
against small solid tumors planted in mice.