Natural Selection Along an Environmental Gradient: A Classic Cline in Mouse Pigmentation

Mullen, Linda; Hoekstra, Hopi E.

doi:10.1111/j.1558-5646.2008.00425.x

Cited by 156 publications

(161 citation statements)

References 63 publications

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“…Using this integrative approach, we provide empirical evidence that natural selection acting on Mc1r alleles has not only contributed to differences between mainland and beach populations Mullen & Hoekstra 2008), but has also fine-tuned …”

Section: Resultsmentioning

confidence: 99%

“…We also collected sand samples along each trap line, representing the range of sand colour at each site. For each sample, we measured brightness following Mullen & Hoekstra (2008).…”

Section: Methodsmentioning

confidence: 99%

“…Sumner 1926;Haldane 1948;Hoekstra et al 2006;Mullen & Hoekstra 2008). However, there are also discrete colour pattern differences among beach mouse subspecies, and it is, in fact, these colour differences that provided the basis for their subspecific designations (Osgood 1909;Howell 1939).…”

Section: Introductionmentioning

confidence: 99%

“…Storz et al 2007), or to both (e.g. Hoekstra et al 2004;Mullen & Hoekstra 2008). In the absence of strong selection, populations will achieve migration-drift equilibrium, resulting in a pattern of isolation-by-distance in which neighbouring populations are more similar than geographically distant populations (Wright 1943;Slatkin 1993).…”

Section: Introductionmentioning

confidence: 99%

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Adaptive basis of geographic variation: genetic, phenotypic and environmental differences among beach mouse populations

et al. 2009

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A major goal in evolutionary biology is to understand how and why populations differentiate, both genetically and phenotypically, as they invade a novel habitat. A classical example of adaptation is the pale colour of beach mice, relative to their dark mainland ancestors, which colonized the isolated sandy dunes and barrier islands on Florida's Gulf Coast. However, much less is known about differentiation among the Gulf Coast beach mice, which comprise five subspecies linearly arrayed on Florida's shoreline. Here, we test the role of selection in maintaining variation among these beach mouse subspecies at multiple levels-phenotype, genotype and the environments they inhabit. While all beach subspecies have light pelage, they differ significantly in colour pattern. These subspecies are also genetically distinct: pair-wise F ST -values range from 0.23 to 0.63 and levels of gene flow are low. However, we did not find a correlation between phenotypic and genetic distance. Instead, we find a significant association between the average 'lightness' of each subspecies and the brightness of the substrate it inhabits: the two most genetically divergent subspecies occupy the most similar habitats and have converged on phenotype, whereas the most genetically similar subspecies occupy the most different environments and have divergent phenotypes. Moreover, allelic variation at the pigmentation gene, Mc1r, is statistically correlated with these colour differences but not with variation at other genetic loci. Together, these results suggest that natural selection for camouflage-via changes in Mc1r allele frequency-contributes to pigment differentiation among beach mouse subspecies.

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Section: Resultsmentioning

confidence: 99%

“…We also collected sand samples along each trap line, representing the range of sand colour at each site. For each sample, we measured brightness following Mullen & Hoekstra (2008).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adaptive basis of geographic variation: genetic, phenotypic and environmental differences among beach mouse populations

et al. 2009

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“…Such studies will reveal, for example, whether the predominant role of cisregulatory evolution observed for Drosophila melanin patterning is a general feature of insect pigmentation divergence. Studies of morphological traits controlled by pleiotropic developmental pathways in a variety of organisms suggest cis-regulatory changes are indeed a pervasive source of phenotypic diversification (examples in [87][88][89][90]; recent reviews [45,46]), while studies of variation in traits controlled by developmental systems with less pleiotropysuch as melanin synthesis activated by the dedicated Melanocortin 1 receptor in specialized vertebrate cells -suggest changes in amino acid sequence can be common as well [91].…”

Section: The Promise Of Pigmentationmentioning

confidence: 99%

Development and evolution of insect pigmentation: Genetic mechanisms and the potential consequences of pleiotropy

Wittkopp

Beldade

2009

Seminars in Cell & Developmental Biology

298

291

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a b s t r a c tInsect pigmentation is a premier model system in evolutionary and developmental biology. It has been at the heart of classical studies as well as recent breakthroughs. In insects, pigments are produced by epidermal cells through a developmental process that includes pigment patterning and synthesis. Many aspects of this process also impact other phenotypes, including behavior and immunity. This review discusses recent work on the development and evolution of insect pigmentation, with a focus on pleiotropy and its effects on color pattern diversification.

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Adaptive molecular evolution of MC1R gene reveals the evidence for positive diversifying selection in indigenous goat populations

Ahmad

Liu

Jiang

et al. 2017

Ecology and Evolution

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Detecting signatures of selection can provide a new insight into the mechanism of contemporary breeding and artificial selection and further reveal the causal genes associated to the phenotypic variation. However, the signatures of selection on genes entailing for profitable traits between Chinese commercial and indigenous goats have been poorly interpreted. We noticed footprints of positive selection at

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Natural Selection Along an Environmental Gradient: A Classic Cline in Mouse Pigmentation

Abstract: We revisited a classic study of morphological variation in the oldfield mouse (Peromyscus polionotus) to estimate the strength of selection acting on pigmentation patterns and to identify the underlying genes. We

Cited by 156 publications

References 63 publications

Adaptive basis of geographic variation: genetic, phenotypic and environmental differences among beach mouse populations

Adaptive basis of geographic variation: genetic, phenotypic and environmental differences among beach mouse populations

Development and evolution of insect pigmentation: Genetic mechanisms and the potential consequences of pleiotropy

Adaptive molecular evolution of MC1R gene reveals the evidence for positive diversifying selection in indigenous goat populations

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