Natural Small Molecules Enabled Efficient Immunotherapy through Supramolecular Self-Assembly in P53-Mutated Colorectal Cancer

Ji, Hong; Wang, Wenzhe; Li, Xia; Han, Xiaoying; Zhang, Xinyu; Wang, Juan; Liu, Changxiao; Huang, Luqi; Gao, Wenyuan

doi:10.1021/acsami.1c16737

Cited by 24 publications

(15 citation statements)

References 42 publications

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“…This bioactive gel can be slowly degraded in vivo, not only exerting efficacy through its own pachymaric acid A molecule but also synergizing with other drugs to exert anti-tumor efficacy. Similar manner were also reported, such as honokiol [ 410 ], disulfide-modified GSH-responsive BA [ 411 ] and ursolic acid [ 389 ]. These discoveries suggest that the utilization of self-assembled nanomedicines exhibits a promising avenue for the treatment of cancer.…”

Section: Nanocarriers Based On Active Ingredients From Tcmssupporting

confidence: 79%

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Qiu,

Zhang,

et al. 2023

J Nanobiotechnol

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Traditional Chinese Medicines (TCMs) have been used for centuries for the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due to their poor water solubility, low bioavailability, and potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations. This review summarizes the recent advances in nanocarrier-based delivery systems for various types of active constituents of TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, and quinones, from different natural sources. This review covers the design and preparation of nanocarriers, their characterization, and in vitro/vivo evaluations. Additionally, this review highlights the challenges and opportunities in the field and suggests future directions for research. Nanocarrier-based delivery systems have shown great potential in improving the therapeutic efficacy of TCMs, and this review may serve as a comprehensive resource to researchers in this field. Graphical abstract

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Section: Nanocarriers Based On Active Ingredients From Tcmssupporting

confidence: 79%

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Qiu,

Zhang,

et al. 2023

J Nanobiotechnol

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“…However, HK shows hydrophobicity, low bioavailability and rapid metabolism, which greatly limit its application. Ji et al employed HK to self-assemble into carrier-free nanoparticles (SA) via intermolecular hydrogen bonds and hydrophobic interactions (Figure 1A) [49]. During the assemble process, hydrogen bonding interactions drove 1D complex units' formation, while hydrophobic units promoted further 3D self-assembly, thereby forming SA with hydrophilic outward and hydrophobic inward, respectively.…”

Section: Hydrogen Bonding Interactionmentioning

confidence: 99%

Advance Progress in Assembly Mechanisms of Carrier-Free Nanodrugs for Cancer Treatment

Zhang,

Hu,

Huang

et al. 2023

Molecules

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Nanocarriers have been widely studied and applied in the field of cancer treatment. However, conventional nanocarriers still suffer from complicated preparation processes, low drug loading, and potential toxicity of carriers themselves. To tackle the hindrance, carrier-free nanodrugs with biological activity have received increasing attention in cancer therapy. Extensive efforts have been made to exploit new self-assembly methods and mechanisms to expand the scope of carrier-free nanodrugs with enhanced therapeutic performance. In this review, we summarize the advanced progress and applications of carrier-free nanodrugs based on different types of assembly mechanisms and strategies, which involved noncovalent interactions, a combination of covalent bonds and noncovalent interactions, and metal ions-coordinated self-assembly. These carrier-free nanodrugs are introduced in detail according to their assembly and antitumor applications. Finally, the prospects and existing challenges of carrier-free nanodrugs in future development and clinical application are discussed. We hope that this comprehensive review will provide new insights into the rational design of more effective carrier-free nanodrug systems and advancing clinical cancer and other diseases (e.g., bacterial infections) infection treatment.

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“…In traditional Chinese medicine (TCM), decoctions have long been widely used and are the most frequently employed form of medication . Recently, researchers have discovered the presence of nanoaggregates in TCM decoctions, − offering a new perspective on the scientific connotation of traditional treatments. − These nanoparticles have been identified in various decoctions, including Ge-Gen-Qin-Lian-Tang, Huang-Lian-Jie-Du-Tang, and Nao-Luo-Xin-Tong-Tang . Self-assembled submicrometer particles constructed by berberine and curcumin through noncovalent bonding significantly enhance antimicrobial activity .…”

Section: Introductionmentioning

confidence: 99%

Study on the Nanoaggregate Formation Mechanism and Antipyretic Effect of Maxing Shigan Decoction

Zhao,

Zhang,

Fan

et al. 2024

ACS Omega

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Traditional Chinese medicine (TCM) formula decoctions easily form nanoaggregates due to self-assembly during the decoction process. However, research on nanoaggregates in TCM is still in its infancy with limited systematic studies. Maxing Shigan Decoction (MXSGT), a TCM formula, has been commonly used for the treatment of fever for thousands of years in China. This study used MXSGT as an example to investigate the antipyretic effects of MXSGT nanoaggregates (MXSGT-NAs) in its decoction, shedding light on the compatibility mechanisms of Chinese medicine. MXSGT-NAs were isolated by using high-speed centrifugation and dialysis techniques. The morphology, particle size distribution, and electrical potential of MXSGT-NAs were characterized. High-performance liquid chromatography (HPLC) was used to detect ephedrine and pseudoephedrine in MXSGT-NAs. The self-assembly mechanism of MXSGT-NAs was investigated by deconstructing the prescription. In pharmacodynamic experiments, a rat fever model was established through the subcutaneous injection of dry yeast to investigate the antipyretic effects of MXSGT-NAs. The results showed the presence of regularly shaped spherical nanoaggregates in MXSGT. It contains carbon, oxygen (O), sulfur (S), sodium, aluminum (Al), calcium (Ca), iron, magnesium, bismuth (Bi), etc. MXSGT-NAs exerted substantial antipyretic effects on febrile rats. Furthermore, we found micrometer-sized particles composed of Ca, O, S, potassium, and Bi in Shi gao decoctions. This study is the first to provide evidence for the self-assembling property of Shi gao, elucidate the scientific connotation of dispensing Shi gao in MXSGT, and provide a novel perspective for the study of TCM decoctions.

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Natural Small Molecules Enabled Efficient Immunotherapy through Supramolecular Self-Assembly in P53-Mutated Colorectal Cancer

Cited by 24 publications

References 42 publications

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Advance Progress in Assembly Mechanisms of Carrier-Free Nanodrugs for Cancer Treatment

Study on the Nanoaggregate Formation Mechanism and Antipyretic Effect of Maxing Shigan Decoction

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