Natural Small Molecules in Gastrointestinal Tract and Associated Cancers: Molecular Insights and Targeted Therapies

Islam, Fahadul; Mitra, Saikat; Emran, Talha Bin; Khan, Zidan; Nath, Nikhil; Das, Rajib; Sharma, Rohit; Awadh, Ahmed Abdullah Al; Park, Moon Nyeo; Kim, Bonglee

doi:10.3390/molecules27175686

Cited by 11 publications

(4 citation statements)

References 142 publications

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“…Hydrogels have the ability to manage the distribution of various therapeutic substances, such as small drug molecules, large molecular pharmaceuticals, and cells, both spatially and temporally [298]. They act as a foundation for various physiochemical reactions with enclosed medications, and can regulate drug delivery thanks to their customizable physical characteristics, manageable degradability, and capacity to protect delicate compounds from deterioration [183].…”

Section: Hydrogelmentioning

confidence: 99%

Anti-Obesity Drug Delivery Systems: Recent Progress and Challenges

Ashour,

Mabrouk,

Aboelnasr

et al. 2023

Pharmaceutics

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Obesity has reached an epidemic proportion in the last thirty years, and it is recognized as a major health issue in modern society now with the possibility of serious social and economic consequences. By the year 2030, nearly 60% of the global population may be obese or overweight, which emphasizes a need for novel obesity treatments. Various traditional approaches, such as pharmacotherapy and bariatric surgery, have been utilized in clinical settings to treat obesity. However, these methods frequently show the possibility of side effects while remaining ineffective. There is, therefore, an urgent need for alternative obesity treatments with improved efficacy and specificity. Polymeric materials and chemical strategies are employed in emerging drug delivery systems (DDSs) to enhance therapy effectiveness and specificity by stabilizing and controlling the release of active molecules such as natural ingredients. Designing DDSs is currently a top priority research objective with an eye towards creating obesity treatment approaches. In reality, the most recent trends in the literature demonstrate that there are not enough in-depth reviews that emphasize the current knowledge based on the creation and design of DDSs for obesity treatment. It is also observed in the existing literature that a complex interplay of different physical and chemical parameters must be considered carefully to determine the effectiveness of the DDSs, including microneedles, for obesity treatment. Additionally, it is observed that these properties depend on how the DDS is synthesized. Although many studies are at the animal-study stage, the use of more advanced DDS techniques would significantly enhance the development of safe and efficient treatment approaches for obese people in the future. Considering these, this review provides an overview of the current anti-obesity treatment approaches as well as the conventional anti-obesity therapeutics. The article aims to conduct an in-depth discussion on the current trends in obesity treatment approaches. Filling in this knowledge gap will lead to a greater understanding of the safest ways to manage obesity.

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Section: Hydrogelmentioning

confidence: 99%

Anti-Obesity Drug Delivery Systems: Recent Progress and Challenges

Ashour,

Mabrouk,

Aboelnasr

et al. 2023

Pharmaceutics

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“…In vivo and in vitro studies have shown that NPs that promote lethal autophagy are useful against tumor treatment resistance. NPs activate cancer cell autophagy, improve chemotherapeutic drug sensitivity by increasing lysosomal membrane permeability, and induce tumor cell apoptosis by activating intact autophagic flow through several pathways including PI3K/AKT/mTOR, AMPK, and ROS [ 82 , 83 ]. Several NPs that can be utilized to induce lethal autophagy against drug resistance are listed in Table 2 .…”

Section: Natural Products Overcome Autophagy-mediated Tumor Drug Resi...mentioning

confidence: 99%

Focusing on the Role of Natural Products in Overcoming Cancer Drug Resistance: An Autophagy-Based Perspective

Yao

Feng

et al. 2022

Biomolecules

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Autophagy is a critical cellular adaptive response in tumor formation. Nutritional deficiency and hypoxia exacerbate autophagic flux in established malignancies, promoting tumor cell proliferation, migration, metastasis, and resistance to therapeutic interventions. Pro-survival autophagy inhibition may be a promising treatment option for advanced cancer. Furthermore, excessive or persistent autophagy is cytotoxic, resulting in tumor cell death. Targeted autophagy activation has also shown significant promise in the fight against tumor drug resistance. Several research groups have examined the ability of natural products (NPs) such as alkaloids, terpenoids, polyphenols, and anthraquinones to serve as autophagy inhibitors or activators. The data support the capacity of NPs that promote lethal autophagy or inhibit pro-survival autophagy from being employed against tumor drug resistance. This paper discusses the potential applications of NPs that regulate autophagy in the fight against tumor drug resistance, some limitations of the current studies, and future research needs and priorities.

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“…An extensive array of pharmaceutical companies are increasingly focusing on extracting medicinal plants to discover new and powerful natural drugs and their derivatives, and to develop novel medications ( He et al, 2022 ). Organic substances possess the unique ability to not just inhibit the proliferation and dissemination of cancer and other malignant cells but also enhance the body’s immune reactions against tumors ( Miller and Hanna, 2021 ; Huo et al, 2022 ; Islam et al, 2022 ). The distinctive benefits it offers could potentially enhance ongoing tumor immunotherapy efforts and create new opportunities for research and development in this field.…”

Section: Introductionmentioning

confidence: 99%

Investigating the immune mechanism of natural products in the treatment of lung cancer

Yang,

Chen,

Liu

et al. 2024

Front. Pharmacol.

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With the deepening of people’s understanding of lung cancer, the research of lung cancer immunotherapy has gradually become the focus of attention. As we all know, the treatment of many diseases relies on the rich sources, complex and varied compositions and wide range of unique biological properties of natural products. Studies have shown that natural products can exert anticancer effects by inducing tumor cell death, inhibiting tumor cell proliferation, and enhancing tumor cell autophagy. More notably, natural products can adjust and strengthen the body’s immune response, which includes enhancing the function of NK cells and promoting the differentiation and proliferation of T lymphocytes. In addition, these natural products may enhance their anticancer effects by affecting inhibitory factors in the immune system, hormone levels, enzymes involved in biotransformation, and modulating other factors in the tumor microenvironment. The importance of natural products in lung cancer immunotherapy should not be underestimated. However, the specific links and correlations between natural products and lung cancer immunity are not clear enough, and further studies are urgently needed to clarify the relationship between the two. In this paper, we will focus on the correlation between natural products and lung cancer immune responses, with a view to providing new research perspectives for immunotherapy of lung cancer.

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Natural Small Molecules in Gastrointestinal Tract and Associated Cancers: Molecular Insights and Targeted Therapies

Cited by 11 publications

References 142 publications

Anti-Obesity Drug Delivery Systems: Recent Progress and Challenges

Anti-Obesity Drug Delivery Systems: Recent Progress and Challenges

Focusing on the Role of Natural Products in Overcoming Cancer Drug Resistance: An Autophagy-Based Perspective

Investigating the immune mechanism of natural products in the treatment of lung cancer

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