Natural sources, biological effects, and pharmacological properties of cynaroside

Bouyahya, Abdelhakim; Taha, Douae; Benali, Taoufiq; Zengin, Gökhan; Omari, Nasreddine El; Khalid, Asaad; Abdalla, Ashraf N.; Ardianto, Chrismawan; Tan, Ching Siang; Ming, Long Chiau; Sahib, Narjis

doi:10.1016/j.biopha.2023.114337

Cited by 18 publications

(9 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In kidney bean, quercetin5-O-glucuronide and quercetin-3-O-sambubioside were more abundant than in other legumes and cynaroside and astragalin were specifically contained. Cynaroside possesses antibacterial, antifungal, antileishmanial, hepatoprotective, antidiabetic, and anticancer properties . Astragalin exerts therapeutic effects against diverse diseases, covering osteoporosis, cancers, mastitis, osteoarthritis, ulcerative colitis, neuropathy, reproductive system diseases, and respiratory diseases …”

Section: Resultsmentioning

confidence: 99%

“…Cynaroside possesses antibacterial, antifungal, antileishmanial, hepatoprotective, antidiabetic, and anticancer properties. 38 Astragalin exerts therapeutic effects against diverse diseases, covering osteoporosis, cancers, mastitis, osteoarthritis, ulcerative colitis, neuropathy, reproductive system diseases, and respiratory diseases. 39 Health-Promoting Flavonoids in Legumes.…”

Section: Flavonoid Profiles Of Five Fresh Legumes Detected Bymentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Nutritional Diversity in Five Fresh Legumes Using Flavonoids Metabolomics and Postharvest Botrytis cinerea Defense Analysis of Peas Mediated by Sakuranetin

Zhao,

Zhang,

Lang

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Legumes possess several bioactive nutrients, including flavonoids, and the study of the flavonoid profile of legumes is of great significance to human health. Using widely targeted metabolomics, we revealed the flavonoid profiles of five popular fresh legumes: cowpea, soybean, pea, fava bean, and kidney bean. A total of 259 flavonoids were identified, and the flavonoid accumulation patterns of the five legumes were remarkably different. In addition to analyzing common and species-specific flavonoids in the five legumes, we also generalized representative flavonoids of various subclasses. We related these to the health-promoting effects of legumes. Furthermore, legumes' total flavonoid content and antioxidant system activity were also detected. Intriguingly, sakuranetin, the sole flavonoid phytoalexin that can be induced by UV radiation, was detected only in the peas by metabolomics. Meanwhile, we found that UV treatment could significantly increase the sakuranetin content and the postharvest Botrytis cinerea resistance of pea pods. This study provides clues for the target diet, industrial development of legumes, and a new idea for the postharvest preservation of peas.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Flavonoid Profiles Of Five Fresh Legumes Detected Bymentioning

confidence: 99%

Comparison of Nutritional Diversity in Five Fresh Legumes Using Flavonoids Metabolomics and Postharvest Botrytis cinerea Defense Analysis of Peas Mediated by Sakuranetin

Zhao,

Zhang,

Lang

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Besides their plant functions, the major phenolics detected are pharmacologically described with relevant therapeutic bioactivities. Luteolin-7- O -glucoside has demonstrated anti-inflammatory, antioxidant, antidiabetic, metabolite-modulatory, antimicrobial, and anticarcinogenic activities [ 69 , 70 , 71 ]; it has been suggested that it is bioavailable when circulating in the organism, without being metabolized to its conjugates in the gastrointestinal tract [ 72 ], which alters the physicochemical properties of flavonoids and can affect their biological activity [ 73 ]. Salicylic acid has documented anti-inflammatory, analgesic, antiseptic, antipyretic, antimicrobial, comedolytic, and keratolytic/desmolytic properties [ 74 , 75 ].…”

Section: Resultsmentioning

confidence: 99%

From Threat to Opportunity: Harnessing the Invasive Carpobrotus edulis (L.) N.E.Br for Nutritional and Phytotherapeutic Valorization Amid Seasonal and Spatial Variability

Pereira,

Neng,

Custódio

2023

Marine Drugs

View full text Add to dashboard Cite

Carpobrotus edulis (L.) N.E.Br. (Hottentot-fig) is a problematic invasive species found in coastal areas worldwide. Mechanical removal is a common control method, leaving the removed biomass available as a possible source of natural phytochemicals with prospective commercial applications. While the Hottentot-fig’s vegetative organs have been studied previously, this work establishes for the first time a seasonal and spatial comparative analysis of its nutritional, chemical, and bioactivity profiles (in three locations over four seasons). Proximate and mineral contents were assessed, along with its phenolic composition and in vitro antioxidant and anti-inflammatory properties. Hottentot-fig’s biomass offered a good supply of nutrients, mainly carbohydrates, proteins, and minerals, with a tendency for higher concentrations of the most relevant minerals and proteins in autumn and winter, and in plants from sites A (Ria de Alvor lagoon) and B (Ancão beach). The extracts were rich in polyphenolics, with higher levels in spring and summer, especially for luteolin-7-O-glucoside and salicylic and coumaric acids. The extracts were also effective antioxidants, with stronger radical scavenging activities in spring and summer, along with anti-inflammatory properties. Our results suggest that the usually discarded plant material of this invasive halophyte could be valuable as a source of natural products with potential biotechnological applications in the food and nutraceutical industries.

show abstract

“…BCL2 and CAS3 family protein expressions play crucial roles in the apoptotic pathway (Abdolmaleki et al, 2023). BCL2 family proteins inhibit apoptosis by regulating membrane channel openings and apoptotic material flow, while CAS3 is a pro‐apoptotic protein whose reduction promotes early‐stage embryonic development (Bouyahya et al, 2023; Li et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Improving the developmental competences of porcine parthenogenetic embryos by Notoginsenoside R1‐induced enhancement of mitochondrial activity and alleviation of proapoptotic events

He,

Liu,

Wang

et al. 2023

Reprod Domestic Animals

View full text Add to dashboard Cite

Notoginsenoside R1 (NGR1), derived from the Panax notoginseng root and rhizome, exhibits diverse pharmacological influences on the brain, neurons, and osteoblasts, such as antioxidant effects, mitochondrial function protection, energy metabolism regulation, and inhibition of oxygen radicals, apoptosis, and cellular autophagy. However, its effect on early porcine embryonic development remains unclear. Therefore, we investigated NGR1's effects on blastocyst quality, reactive oxygen species (ROS) levels, glutathione (GSH) levels, mitochondrial function, and embryonic development‐related gene expression in porcine embryos by introducing NGR1 during the in vitro culture (IVC) of early porcine embryos. Our results indicate that an addition of 1 μM NGR1 significantly increased glutathione (GSH) levels, blastocyst formation rate, and total cell number and proliferation capacity; decreased ROS levels and apoptosis rates in orphan‐activated porcine embryos; and improved intracellular mitochondrial distribution, enhanced membrane potential, and reduced autophagy. In addition, pluripotency‐related factor levels were elevated (NANOG and octamer‐binding transcription factor 4 [OCT4]), antioxidant‐related genes were upregulated (nuclear factor‐erythroid 2‐related factor 2 [NRF2]), and apoptosis‐ (caspase 3 [CAS3]) and autophagy‐related genes (light chain 3 [LC3B]) were downregulated. These results indicate that NGR1 can enhance early porcine embryonic development by protecting mitochondrial function.

show abstract

Natural sources, biological effects, and pharmacological properties of cynaroside

Cited by 18 publications

References 95 publications

Comparison of Nutritional Diversity in Five Fresh Legumes Using Flavonoids Metabolomics and Postharvest Botrytis cinerea Defense Analysis of Peas Mediated by Sakuranetin

Comparison of Nutritional Diversity in Five Fresh Legumes Using Flavonoids Metabolomics and Postharvest Botrytis cinerea Defense Analysis of Peas Mediated by Sakuranetin

From Threat to Opportunity: Harnessing the Invasive Carpobrotus edulis (L.) N.E.Br for Nutritional and Phytotherapeutic Valorization Amid Seasonal and Spatial Variability

Improving the developmental competences of porcine parthenogenetic embryos by Notoginsenoside R1‐induced enhancement of mitochondrial activity and alleviation of proapoptotic events

Contact Info

Product

Resources

About