Natural T-cell responses against minor histocompatibility antigen (mHag) HY following HLA-matched hematopoietic cell transplantation: what are the requirements for a ‘good’ mHag?

Abstract

Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

Diverse Patterns of T-Cell Response against Multiple Newly Identified Human Y Chromosome–Encoded Minor Histocompatibility Epitopes

“…This epitope, derived from JARID1D (SMCY), was predicted (JARID1D311) and verified as immunogenic in FM patients and normal females, supporting both the validity of our bioinformatic algorithms and the functional sensitivity of our post-transplant ELISPOT assays. However, responses were only detected in 33% of FM patients (39,36) and 6 other peptides elicited more frequent responses in FM patients. This included 2 other peptides derived from JARID1D as well as peptides from 4 other Y-encoded proteins not previously known to elicit HLA A*0201 restricted responses.…”

Glutathione S-transferase T1 is a potential new target for the hepatic component of graft vs host disease after HSCT

“…Human mHAs include some encoded by the Y chromosome genes and others encoded by autosomal genes. 1 Nevertheless, there is a complete lack of studies addressing the B-cell response to mHAs in GVHD.…”