Natural therapies assessment for the treatment of endometriosis

Ricci, Analía Gabriela; Olivares, Carla Noemí; Bilotas, Mariela Andrea; Bastón, Juan Ignacio; Singla, José Javier; Meresman, Gabriela Fabiana; Barañao, Rosa Inés

doi:10.1093/humrep/des369

Cited by 86 publications

(105 citation statements)

References 37 publications

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“…In the first study evaluating the effects of resveratrol on endometriosis lesions,82 daily oral gavage of resveratrol significantly diminished the number and size of endometriotic lesions in mouse models. These preliminary results have been confirmed by two other studies 83,84. In both studies, performed on mouse models, resveratrol significantly reduced the number and volume of the endometriotic lesions, through a reduction in cell proliferation, vascular density, and favoring apoptosis.…”

Section: Complementary and Alternative Medicinesupporting

confidence: 72%

Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care

Buggio¹,

Barbara²,

Facchin³

et al. 2017

IJWH

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Endometriosis has a multifactorial etiology. The onset and progression of the disease are believed to be related to different pathogenic mechanisms. Among them, the environment and lifestyle may play significant roles. Diet, dietary supplements, physical exercise, osteopathy, massage, acupuncture, transcutaneous electrical nerve stimulation, and Chinese herbal medicine may represent a complementary and feasible approach in the treatment of symptoms related to the disease. In this narrative review, we aimed to examine the most updated evidence on these alternative approaches implicated in the self-management of the disease. In addition, several studies have demonstrated that endometriosis may negatively impact mental health and quality of life, suggesting that affected women may have an increased risk of developing psychological suffering as well as sexual problems due to the presence of pain. In light of these findings, we discuss the importance of integrating psychological interventions (including psychotherapy) and sexual therapy in endometriosis treatment.

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Section: Complementary and Alternative Medicinesupporting

confidence: 72%

Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care

Buggio¹,

Barbara²,

Facchin³

et al. 2017

IJWH

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show abstract

“…Brunner-Tran et al first reported the therapeutic effect of resveratrol in an experimental endometriosis model by showing that it decreased endometrial cell proliferation and increased apoptosis [21]. Ricci et al [22] demonstrated both an increase in cell death and the antiangiogenic effects of resveratrol in an endometriosis model and human endometrial cell culture. Rudzitis-Auth et al reported that resveratrol reduced the proliferation of endothelial cells in the ectopic implants, which was shown by significantly decreased micro-vessel density [23].…”

Section: Commentsmentioning

confidence: 99%

Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis?

Tekın

Güven

Kırbaş

et al. 2015

European Journal of Obstetrics & Gynecology and Reproductiv

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“…9 Starting from the report by Bruner-Tran et al that RSV is promising for the prevention and treatment of endometriosis, 10 numerous preclinical studies have established that RSV appears to be a promising compound for treating endometriosis. [11][12][13][14][15][16] In a continued effort to search for novel therapeutics for adenomyosis, we sought to determine whether RSV has any therapeutic potential in a mice model of adenomyosis. Besides its desirable antiangiogenic activity as demonstrated in cancer and endometriosis, RSV also has several, additional desirable features.…”

mentioning

confidence: 99%

Resveratrol Reduces Myometrial Infiltration, Uterine Hyperactivity, and Stress Levels and Alleviates Generalized Hyperalgesia in Mice With Induced Adenomyosis

et al. 2015

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In this study, we sought to determine whether resveratrol (RSV), a nonhormonal compound, would suppress the myometrial infiltration, improve pain behavior, lower stress level, improve the expression of some proteins known to be involved in adenomyosis, and reduce uterine contractility in a mice model of adenomyosis. Adenomyosis was induced in 28 female ICR mice neonatally dosed with tamoxifen, while another 12 (group C) were dosed with solvent only, serving as a blank control. Starting from 4 weeks after birth, hotplate test was administrated to all mice every 4 weeks. At the 16th week, all mice with induced adenomyosis were randomly divided into 3 groups: low-dose RSV (2 mg/kg), high-dose RSV (3 mg/kg), and untreated. Group C received no treatment. After 3 weeks of treatment, they were hotplate tested again, their uterine horns and brains were harvested, and a blood sample was taken to measure the plasma corticosterone (CORT) level by enzyme-linked immunosorbent assay. The left uterine horn was used for immunohistochemistry analysis. The brain stem nucleus raphe magnus (NRM) sections were subjected to immunofluorescence staining for glutamic acid decarboxylase isoform 65 (GAD65). The depth of myometrial infiltration and uterine contractility was evaluated. We found that RSV is well tolerated and that it dose dependently suppressed myometrial infiltration, improved generalized hyperalgesia, reduced uterine contractility and lowered plasma CORT levels, and improved the expression of some proteins known to be involved in adenomyosis. It also elevated the number of GAD65-expressing neurons in the brain stem NRM, possibly boosting the GABAergic inhibition of pain due to adenomyosis. Therefore, RSV appears to be a promising compound for treating adenomyosis.

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Natural therapies assessment for the treatment of endometriosis

Abstract: This study was supported by ANPCYT (PICT 6384 BID 1201 OC-AR) and CONICET (PIP 5471), Argentina. None of the authors has any conflict of interest to declare.

Cited by 86 publications

References 37 publications

Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care

Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care

Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis?

Resveratrol Reduces Myometrial Infiltration, Uterine Hyperactivity, and Stress Levels and Alleviates Generalized Hyperalgesia in Mice With Induced Adenomyosis

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