Natural tooth enamel and its analogs

Zhao, Hewei; Liu, Shaojia; Jiang, Lu; Yang, Xiuyi; Yang, Zhao; Li, Fengshi; Guo, Lin

doi:10.1016/j.xcrp.2022.100945

Cited by 12 publications

(18 citation statements)

References 105 publications

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“…3,19,40 The alternation of layers should contribute to uniform filling of the template surface, achieve stable conjugation of hydroxyapatite crystals, and increase the thickness of coatings with a reproducible film structure, which in turn is important for practical applications. 3,19,31,41 The samples studied in this article have the following design.…”

Section: Obtaining Nano-chap For the Mineralization Procedurementioning

confidence: 99%

“…The alternation of PDA and nano-cHAp layers in the formation of the mineralized layer has been used to reproduce the hierarchical structure of tooth enamel, in which nanocrystals of substituted calcium apatite alternate with nanolayers of the organic matrix interfacing them. 3,19,40 The alternation of layers should contribute to uniform filling of the template surface, achieve stable conjugation of hydroxyapatite crystals, and increase the thickness of coatings with a reproducible film structure, which in turn is important for practical applications. 3,19,31,41 The samples studied in this article have the following design.…”

Section: Obtaining Nano-chap For the Mineralization Procedurementioning

confidence: 99%

“…2−5 This requires imitating the natural tissue: the fibrous structure and morphology of the dental organomineral complex with its unique biomechanical properties. 3,5,6 Since hydroxyapatite nanocrystals (HAp) are the initial inorganic substances in solid tissues, 7 it is biomimetic layer-bylayer mineralization that is considered to be the ideal strategy to build an apatite-like layer (interface) on the surface of the restorative mineralized tissue. 8 However, in order to implement the biomineralization process, it is necessary to use an organic matrix that controls the assembly of inorganic crystals to form organomineral hybrid apatite-like materials.…”

Section: Introductionmentioning

confidence: 99%

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Rapid Deposition of the Biomimetic Hydroxyapatite-Polydopamine-Amino Acid Composite Layers onto the Natural Enamel

Seredin,

Goloshchapov,

Emelyanova

et al. 2024

ACS Omega

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In this work, we developed a technology that enables rapid deposition of biomimetic composite films onto natural enamel slices (known as biotemplates). These films are composed of polydopamine (PDA) and nanocrystalline carbonatesubstituted hydroxyapatite (nano-cHAp) that have been functionalized with amino acid L-Arginine. We utilized atomic force microscopy (AFM) and scattering scanning near-field optical microscopy (s-SNOM) combined with infrared (IR) synchrotron to achieve nanoscale spatial resolution for both IR absorption and topography analyses. This combined analytical modality allowed us to understand how morphology connects to local changes in the chemical environment on the biotemplate surface during the deposition of the bioinspired coating. Our findings revealed that when using the proposed technology and after the deposition of the first PDA layer, the film formed on the enamel surface nearly covers the entire surface of the specimen whose thickness is larger on the surface of the emerging enamel prisms. Calculation of the crystallinity index for the biomimetic layer showed a multiple increase compared with natural enamel. This indicates regular and dense aggregation of nano-cHAp into larger crystals, imitating the morphology of natural enamel rods. The microhardness of the formed PDA-based biomimetic layer mineralized with nano-cHAp functionalized with amino acid L-Arginine deposited on natural enamel was practically the same as that of natural enamel. The characterization of nano-cHAp-amino acid-PDA layers using IR and Raman microspectroscopy showed that L-arginine acts as a conjunction agent in the formation of mineralized biomimetic composite coatings. The uniformity of the mechanisms of PDA layer formation under different deposition conditions and substrate types allows for the formation of coatings regardless of the macro-and micromorphology of the template. Therefore, the results obtained in this work have a high potential for future clinical applications in dental practice.

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Section: Obtaining Nano-chap For the Mineralization Procedurementioning

confidence: 99%

Section: Obtaining Nano-chap For the Mineralization Procedurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid Deposition of the Biomimetic Hydroxyapatite-Polydopamine-Amino Acid Composite Layers onto the Natural Enamel

Seredin,

Goloshchapov,

Emelyanova

et al. 2024

ACS Omega

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“…A brief survey of the state-of-the-art materials of this field is given here. For a comprehensive evaluation, readers can refer to recent reviews on this topic [ 91 , 92 ]. The seminal work of Kotov’s group used ZnO nanorods as the inorganic motif, and the interrod gaps were filled by layer-by-layer (LBL) assembly of polyallylamine (PAAm) and polyacrylic acid (PAA) [ 43 ] ( Figure 4 A).…”

Section: Enamel-inspired Biomimetic Materialsmentioning

confidence: 99%

Tooth Diversity Underpins Future Biomimetic Replications

2023

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Although the evolution of tooth structure seems highly conserved, remarkable diversity exists among species due to different living environments and survival requirements. Along with the conservation, this diversity of evolution allows for the optimized structures and functions of teeth under various service conditions, providing valuable resources for the rational design of biomimetic materials. In this review, we survey the current knowledge about teeth from representative mammals and aquatic animals, including human teeth, herbivore and carnivore teeth, shark teeth, calcite teeth in sea urchins, magnetite teeth in chitons, and transparent teeth in dragonfish, to name a few. The highlight of tooth diversity in terms of compositions, structures, properties, and functions may stimulate further efforts in the synthesis of tooth-inspired materials with enhanced mechanical performance and broader property sets. The state-of-the-art syntheses of enamel mimetics and their properties are briefly covered. We envision that future development in this field will need to take the advantage of both conservation and diversity of teeth. Our own view on the opportunities and key challenges in this pathway is presented with a focus on the hierarchical and gradient structures, multifunctional design, and precise and scalable synthesis.

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“…Human dental enamel comprises nanoscale hydroxyapatite (HAp) crystallites coaligned into micron-scale rods and surrounding inter-rod regions. ,,,,, The structure of enamel ensures exceptional mechanical properties, e.g., high hardness and toughness, − but it has a low resistance to acidic attack that causes demineralization of the enamel. − The acidic environment may arise from the activity of bacteria (e.g., Streptococcus mutans and Lactobacilli) that can lead to dental caries − that remain a global disease. , Other mechanisms such as acidic drink consumption may lead to nonbacterial acid erosion . In both cases, acid exposure leads to preferential demineralization of the enamel and loss of material manifested across many different scales, down to the nanoscale. ,,− Several experiments have been carried out to investigate enamel demineralization either statically (carious or artificial demineralization) ,,,,, or dynamically during artificial demineralization. ,,,, Various techniques such as electron microscopy, X-ray diffraction, radiography, and tomography were used and have shown that not only was there loss of material but also that the structural parameters such as crystallite size and texture were altered after demineralization and need to be assessed using different analytical techniques.…”

Section: Introductionmentioning

confidence: 99%

The DIAD Approach to Correlative Synchrotron X-ray Imaging and Diffraction Analysis of Human Enamel

Besnard,

Marie,

Sasidharan

et al. 2024

Chemical & Biomedical Imaging

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The Dual Imaging and Diffraction (DIAD) beamline at Diamond Light Source (Didcot, U.K.) implements a correlative approach to the dynamic study of materials based on concurrent analysis of identical sample locations using complementary X-ray modalities to reveal structural detail at various length scales. Namely, the underlying beamline principle and its practical implementation allow the collocation of chosen regions within the sample and their interrogation using real-space imaging (radiography and tomography) and reciprocal space scattering (diffraction). The switching between the two principal modes is made smooth and rapid by design, so that the data collected is interlaced to obtain near-simultaneous multimodal characterization. Different specific photon energies are used for each mode, and the interlacing of acquisition steps allows conducting static and dynamic experiments. Building on the demonstrated realization of this state-of-the-art approach requires further refining of the experimental practice, namely, the methods for gauge volume collocation under different modes of beam−sample interaction. To address this challenge, experiments were conducted at DIAD devoted to the study of human dental enamel, a hierarchical structure composed of hydroxyapatite mineral nanocrystals, as a static sample previously affected by dental caries (tooth decay) as well as under dynamic conditions simulating the process of acid demineralization. Collocation and correlation were achieved between WAXS (wide-angle X-ray scattering), 2D (radiographic), and 3D (tomographic) imaging. While X-ray imaging in 2D or 3D modes reveals real-space details of the sample microstructure, X-ray scattering data for each gauge volume provided statistical nanoscale and ultrastructural polycrystal reciprocal-space information such as phase and preferred orientation (texture). Careful registration of the gauge volume positions recorded during the scans allowed direct covisualization of the data from two modalities. Diffraction gauge volumes were identified and visualized within the tomographic data sets, revealing the underlying local information to support the interpretation of the diffraction patterns. The present implementation of the 4D microscopy paradigm allowed following the progression of demineralization and its correlation with time-dependent WAXS pattern evolution in an approach that is transferable to other material systems.

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Natural tooth enamel and its analogs

Cited by 12 publications

References 105 publications

Rapid Deposition of the Biomimetic Hydroxyapatite-Polydopamine-Amino Acid Composite Layers onto the Natural Enamel

Rapid Deposition of the Biomimetic Hydroxyapatite-Polydopamine-Amino Acid Composite Layers onto the Natural Enamel

Tooth Diversity Underpins Future Biomimetic Replications

The DIAD Approach to Correlative Synchrotron X-ray Imaging and Diffraction Analysis of Human Enamel

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