Natural UV-protective organic matter in thermal water

Varga, Csaba; László, Mónika; Gerencsér, Gellért; Gyöngyi, Zoltán; Szendi, Katalin

doi:10.1016/j.jphotobiol.2015.01.007

Cited by 11 publications

(10 citation statements)

References 12 publications

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“…The two organic-rich medicinal water under study showed relevant biological effects in the previous studies performed by in vitro bacterial tests. In an in toto study, volatile compounds of KSZ water decreased the negative control revertant rate of Salmonella TA 100 bacteria with 50% in the desiccators' Ames test, modified especially for the volatile mutagens (Varga et al 2015). This phenomenon could not be unequivocally explained.…”

Section: Discussionmentioning

confidence: 83%

“…Photo-biological effects of organic extracts of 5 selected medicinal (or simply thermal) waters were also studied previously. Four out of the five investigated medicinal water isolates showed exceeding UV-protective effect on the TA 100 strains in a modified Ames test (Varga et al 2015). Later, it became clear that the photo-protective effect was not general, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Researchers have recently published in increasing number the positive effects of thermal water on the keratinocytes, and these studies show antioxidant, anti-inflammatory, anti-allergic, UV-protective and antiangiogenic effects (Jung et al 2009;Varga et al 2015;Zöller et al 2015;Karagülle et al 2018).…”

Section: Introductionmentioning

confidence: 99%

“…The recent study aims to compare two water samples in the HaCaT cultures: a water sample which previously showed UV-protective effect in Ames test (Varga et al 2015), Gyopáros Spa water (GYP) also located in SE Hungary, and one which did not exert any protective effect (KSZ) (Gerencsér 2014).…”

Section: Introductionmentioning

confidence: 99%

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Effects of medicinal waters on the UV-sensitivity of human keratinocytes – a comparative pilot study

et al. 2019

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Balneotherapy has been used to treat several diseases including locomotor, neurological and dermatological conditions. The basis of the "organic hypothesis" of medical balneology is that medicinal waters, especially thermal spa and hot spring waters, contain a high variability of organic components with possible biological effects, including UV photo-protection. The recent study aims to clarify this effect in a human keratinocyte cell line model. Results confirm that organic-rich extract of selected medicinal waters might protect skin-derived cells from DNA damage. These results give a clinical relevance to medicinal waters or pharmaceutical products prepared from them in preventing the adverse effects of solar or artificial UV radiation on the human skin.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of medicinal waters on the UV-sensitivity of human keratinocytes – a comparative pilot study

et al. 2019

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“…Transmittance of the water is highly important in this case because colour and turbidity might considerably modify the effective distance of the irradiation. Another disadvantage is if the organic content of the water shows protective action on the effects of UV light on the microbial DNA (Varga et al 2015).…”

Section: Discussionmentioning

confidence: 99%

To treat or not to treat? Misbeliefs in spa water disinfection

Varga

2019

Int J Biometeorol

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Spa waters should be left untreated" says the dogmatic approach. Health authorities of European countries having traditional spa culture strictly control hygienic conditions of bathing in thermal/mineral waters. These regulations are based on the assumption that chemical treatment (disinfection) of such waters impacts their healing effects. However, a slow change of paradigm has been observed in studying the mode of action of spa waters that could help overcome recent attitudes. Organic content or the role of microbiome has also been emphasized by some authors recently. The article deals with possible interactions among aquatic microorganisms and the disinfection and health effects of spa waters and tries to explain the new findings in this field.

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On the proper study design applicable to experimental balneology

Varga

2015

Int J Biometeorol

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The simple message of this paper is that it is the high time to reevaluate the strategies and optimize the efforts for investigation of thermal (spa) waters. Several articles trying to clear mode of action of medicinal waters have been published up to now. Almost all studies apply the unproven hypothesis, namely the inorganic ingredients are in close connection with healing effects of bathing. Change of paradigm would be highly necessary in this field taking into consideration the presence of several biologically active organic substances in these waters. A successful design for experimental mechanistic studies is approved.

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Natural UV-protective organic matter in thermal water

Cited by 11 publications

References 12 publications

Effects of medicinal waters on the UV-sensitivity of human keratinocytes – a comparative pilot study

Effects of medicinal waters on the UV-sensitivity of human keratinocytes – a comparative pilot study

To treat or not to treat? Misbeliefs in spa water disinfection

On the proper study design applicable to experimental balneology

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