Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects

Woods, Nicola; Niwasabutra, Kanidta; Acevedo, Reinaldo; Igoli, John O.; Altwaijry, Najla; Tusiimire, Jonans; Gray, Alexander; Watson, David; Ferro, Valerie A.

doi:10.1016/b978-0-12-804019-5.00011-6

Cited by 21 publications

(19 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The adjuvants of Table 7 represent traditional and well-established agents. However, many natural products (e.g., polysaccharides, α-galactosylceramide), 67 endogenous cytokines (e.g., interleukins, interferons, GM-CSF), 68 and synthetic compounds (e.g., saponin derivatives) 69 have been examined in preclinical and experimental settings. As the molecular pathways underlying the effects of these adjuvants have been investigated, it has become clearer that the pattern recognition receptor (PRR) system of the innate immune system is targeted by many of these agents.…”

Section: Adjuvants Mrna Sequence Modifications Formulations and Dementioning

confidence: 99%

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Adjuvants Mrna Sequence Modifications Formulations and Dementioning

confidence: 99%

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

et al. 2021

View full text Add to dashboard Cite

show abstract

“…To the best of our knowledge, from the mechanistic point of view, PLA2 hydrolyses phospholipids at low rate for prolonged periods, so indirectly disrupts the cell membrane of bacteria (Bank and Shipolini, 1986). In addition, melittin, the major compound of BV, is known for being responsible for most of the antimicrobial, anti-allergic, anti-inflammatory, and anti-cancer effects of BV (Hu, 2006;Dong, 2015;Woods, 2017;Lee, 2019) because of Antimicrobial peptides (AMPs) properties (Adade, 2013). As described in previous studies, melittin increases cell permeability and integrates into phospholipid bilayers in low concentrations, and forms pores in the cell membrane in high concentrations which causes the release of Ca 2+ ions or breaks phospholipid groups (Fennell, Shipman and Cole, 1968;Shipolini, 1984;Adade, 2013;Wu, 2016;Socarras, 2017).…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Antimicrobial Activity of Honeybee (Apis Mellifera) Venom on Gram-Negative Bacteria: Escherichia Coli and Pseudomonas Spp.

HAKTANIR

Masoura

MANTZOURIDOU

et al. 2021

Preprint

View full text Add to dashboard Cite

Honeybee venom (Apitoxin, BV), a secretion substance expelled from the venom gland of bees, has being reported as antimicrobial against various bacterial species; however, the mechanism of action remains uncharacterized. In this study, the antibacterial activity of BV was investigated on hygiene indicator Escherichia coli and the environmental pathogen and spoilage bacterial species, Pseudomonas putida and Pseudomonas fluorescens. An array of methods was combined to elucidate the mode of action of BV. Viability by culture on media was combined with assessing cell injury with flow cytometry analysis. ATP depletion was monitored as an indicator to metabolic activity of cells, by varying BV concentration (75, 225and 500µg/mL), temperature (25°H and 37°o), and time of exposure (0 to 24h). Venom presented moderate inhibitory effect on E. coli by viability assay, caused high membrane permeability and significant ATP loss where the effect was increased by increased concentration. The viability of P. putida was reduced to a greater extent than other tested bacteria at comparable venom concentrations and was dictated by exposure time. On the contrary, P. fluorescens appeared less affected by venom based on viability; however, flow cytometry and ATP analysis highlighted concentration- and time-dependent effect of venom. According to Transmission Electron Microscopy results, the deformation of the cell wall was evident for all species. This implies a common mechanism of action of the BV which is as follows: the cell wall destruction, change of membrane permeability, leakage of cell contents, inactivation of metabolic activity and finally cell death.

show abstract

“…Some plants contain compounds that are medicinally important and are the basis for many modern and traditional medicines. 17 PSCs include psychoactive chemicals and hallucinogens 9 and also comprise natural toxins that act as pesticides and anti-grazing agents. They are arguably some of the most abundant and diverse naturally occurring toxins that exist.…”

Section: Introductionmentioning

confidence: 99%

Paleomedicine and the use of plant secondary compounds in the Paleolithic and Early Neolithic

Hardy

2019

Evolutionary Anthropology

View full text Add to dashboard Cite

Reconstructing plant use before domestication is challenging due to a lack of evidence. Yet, on the small number of sites with assemblages, the wide range of different plant species cannot be explained simply in terms of nutrition. Assemblages from the Lower Paleolithic to the Early Neolithic were examined to investigate the relative edible and medicinal properties of the plants. The assemblages contain a mixture of edible species, plants that are both edible and medicinal, and plants with only medicinal properties. The proportion of medicinal plants at all sites is well above the natural average and increases over time. Mechanisms for preventing intestinal parasitic infections are common among animals and together with chimpanzees’ preventative and curative self‐medication practices suggest an evolutionary context for this behavior. A broad‐spectrum approach to plant collection is likely to have been in place throughout the Paleolithic driven, in part, by the need for medicinal compounds.

show abstract

Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects

Cited by 21 publications

References 103 publications

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

Mechanism of Antimicrobial Activity of Honeybee (Apis Mellifera) Venom on Gram-Negative Bacteria: Escherichia Coli and Pseudomonas Spp.

Paleomedicine and the use of plant secondary compounds in the Paleolithic and Early Neolithic

Contact Info

Product

Resources

About