Natural Vanadium-Containing Jeju Groundwater Inhibits Immunoglobulin E-Mediated Anaphylactic Reaction and Suppresses Eicosanoid Generation and Degranulation in Bone Marrow Derived-Mast Cells

Li, Xian; Lu, Yue; Yang, Ju Hye; Jin, Yufeng; Hwang, Soo Min; Chang, Hyeun Wook

doi:10.1248/bpb.35.216

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…COX-2 converts arachidonic acid to prostaglandin in IgE-mediated mast cells. Arachidonic acids are also converted into leukotrienes by 5-LOX in IgE-mediated mast cells [ 25 ]. To determine whether GBR-SP024 affected COX-2 and 5-LOX mRNA expression, we analyzed COX-2 and 5-LOX mRNA expression in the ear tissues of IgE/Ag-stimulated mice using RT-PCR.…”

Section: Resultsmentioning

confidence: 99%

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Pediococcus Pentosaceus from the Sweet Potato Fermented Ger-Minated Brown Rice Can Inhibit Type I Hypersensitivity in RBL-2H3 Cell and BALB/c Mice Models

Dhong

Park

2021

Microorganisms

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In this study, the effect of GBR fermented with the Pediococcus pentosaceus SP024 strain on IgE/Ag mediated passive cutaneous anaphylaxis (PCA) was investigated. Protocatechuic acid and trans-ferulic acid levels in GBR-SP024 increased more than those in unfermented GBR, respec-tively. The inhibitory activity of GBR-SP024 on β-hexosaminidase release and the level of proin-flammatory cytokine mRNA expression (tumor necrosis factor-α (TNF-α) and interleukin 4 (IL-4)) was observed in IgE/Ag-stimulated RBL-2H3 cells. Western blot analysis showed that GBR-SP024 significantly inhibited the phosphorylation of the linker for activation of T cell (LAT) and nuclear factor-κB (NF-κB) in IgE/Ag-stimulated RBL-2H3 cells. Further, we investigated the anti-allergic effect of GBR-SP024 using PCA murine model. The number of infiltrated immune cells and degranulated mast cells in GBR-SP024 treated dermis was lower than that in the GBR-treated mice. In addition, mRNA expression of 5-lipoxygenase (5-LOX) in the dermis of ear tissue declined in the GBR-SP024–treated group, compared to that in the GBR group. GBR-SP024 was also more effective than GBR at reducing the levels of IL-33 protein expression in IgE/Ag-stimulated BALB/c mice. Our study suggests the potential usage of GBR-SP024 as a dietary supplement or an adjuvant for treating IgE-dependent-allergic diseases.

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Section: Resultsmentioning

confidence: 99%

“…As COX-2 and 5-LOX were both highly expressed in IgE/Ag-stimulated mice, the downregulation of either COX-2 or 5-LOX might inhibit the development of PCA [ 25 ]. COX-2 and 5-LOX are key enzymes that convert arachidonic acid into lipid mediators such as PGE2 and LTE4 [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Pediococcus Pentosaceus from the Sweet Potato Fermented Ger-Minated Brown Rice Can Inhibit Type I Hypersensitivity in RBL-2H3 Cell and BALB/c Mice Models

Dhong

Park

2021

Microorganisms

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Jeju ground water containing vanadium induces normal T cell development and immune activation in chronically stressed mice

et al. 2019

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Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats

Omayone

Olaleye

2021

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats. Methods Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment. Results Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA. Conclusions Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.

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Natural Vanadium-Containing Jeju Groundwater Inhibits Immunoglobulin E-Mediated Anaphylactic Reaction and Suppresses Eicosanoid Generation and Degranulation in Bone Marrow Derived-Mast Cells

Cited by 5 publications

References 26 publications

Pediococcus Pentosaceus from the Sweet Potato Fermented Ger-Minated Brown Rice Can Inhibit Type I Hypersensitivity in RBL-2H3 Cell and BALB/c Mice Models

Pediococcus Pentosaceus from the Sweet Potato Fermented Ger-Minated Brown Rice Can Inhibit Type I Hypersensitivity in RBL-2H3 Cell and BALB/c Mice Models

Jeju ground water containing vanadium induces normal T cell development and immune activation in chronically stressed mice

Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats

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