Natural variability of hepatic biomarkers in Mediterranean deep-sea organisms

Koenig, Samuel; Solé, Montserrat

doi:10.1016/j.marenvres.2012.06.005

Cited by 30 publications

(9 citation statements)

References 65 publications

(70 reference statements)

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“…Although GST enzymes are part of the phase II metabolism, these enzymes can also function as antioxidant enzymes catalyzing the reduction of organic hydroperoxides (Koenig and Sole ´2012). The effect of oxidative stress has also been tested in the endogeic earthworm Aporrectodea caliginosa exposed to a low concentration of 2.5 9 10 3 lg GLY kg -1 dry soil (Givaudan et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Survival, Reproduction, Avoidance Behavior and Oxidative Stress Biomarkers in the Earthworm Octolasion cyaneum Exposed to Glyphosate

Salvio

Menone

Rafael

et al. 2016

Bull Environ Contam Toxicol

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The massive use of glyphosate (GLY) in several countries has increased the interest in investigating its potential adverse effects in non-target organisms. The aim of the present study was to assess the potential effects in survival and reproduction; avoidance behavior and oxidative stress under short-term (48 h) and subchronic exposures (28 days) to GLY in the earthworm Octolasion cyaneum. After 48 h no significant changes in the behavior was observed. In addition, a lower catalase activity at 498 μg GLY kg(-1) dry soil section relative to earthworms from the control section was obtained. After 28 days of exposure inhibition of glutathione S-transferase activity was observed at 535 μg GLY kg(-1) dry soil while no changes in the other endpoints were detected. These results indicate that environmentally relevant concentrations of GLY (up to 996 µg GLY kg(-1) dry soil) did not exert a toxic effect to O. cyaneum.

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Section: Discussionmentioning

confidence: 99%

Survival, Reproduction, Avoidance Behavior and Oxidative Stress Biomarkers in the Earthworm Octolasion cyaneum Exposed to Glyphosate

Salvio

Menone

Rafael

et al. 2016

Bull Environ Contam Toxicol

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“…Some experimental evidence in the literature confirms that the variability of enzymatic parameters across time and/or space is often not only explained by stress factors [12,13,24,25]. Unfortunately, studies addressing the natural variability of biochemical parameters are very scarce, and most of them were related to marine biota [24][25][26][27][28][29]. Cravo et al [25], measuring several biomarkers (including AChE and GST) in the marine clam Ruditapes decussates, concluded that natural variability may act as a confounding factor and must be carefully accounted for in ecotoxicological studies.…”

Section: Discussionmentioning

confidence: 99%

Natural variability of biochemical biomarkers in the macro‐zoobenthos: Dependence on life stage and environmental factors

Scarduelli

Giacchini

Parenti

et al. 2017

Enviro Toxic and Chemistry

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Biomarkers are widely used in ecotoxicology as indicators of exposure to toxicants. However, their ability to provide ecologically relevant information remains controversial. One of the major problems is understanding whether the measured responses are determined by stress factors or lie within the natural variability range. In a previous work, the natural variability of enzymatic levels in invertebrates sampled in pristine rivers was proven to be relevant across both space and time. In the present study, the experimental design was improved by considering different life stages of the selected taxa and by measuring more environmental parameters. The experimental design considered sampling sites in 2 different rivers, 8 sampling dates covering the whole seasonal cycle, 4 species from 3 different taxonomic groups (Plecoptera, Perla grandis; Ephemeroptera, Baetis alpinus and Epeorus alpicula; Tricoptera, Hydropsyche pellucidula), different life stages for each species, and 4 enzymes (acetylcholinesterase, glutathione S-transferase, alkaline phosphatase, and catalase). Biomarker levels were related to environmental (physicochemical) parameters to verify any kind of dependence. Data were statistically elaborated using hierarchical multilevel Bayesian models. Natural variability was found to be relevant across both space and time. The results of the present study proved that care should be paid when interpreting biomarker results. Further research is needed to better understand the dependence of the natural variability on environmental parameters. Environ Toxicol Chem 2017;36:3158-3167. © 2017 SETAC.

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“…Seasonal and/or interannual variations have been reported in both taxa (Bocchetti and Regoli 2006;Koenig and Solé 2012;Kopecka and Pempkowiak 2008;Schmidt et al 2013). The confounding factors relevant to this assessment, which can cause seasonal variations in the biomarker responses, are reproductive cycle and food availability, both related to the seawater temperature.…”

Section: Discussionmentioning

confidence: 99%

An integrated assessment of pollution and biological effects in flounder, mussels and sediment in the southern Baltic Sea coastal area

Dabrowska

Kopko

Lehtonen

et al. 2016

Environ Sci Pollut Res

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Organic and metal contaminants and biological effects were investigated in flounder, mussels, and sediments in the southern Baltic Sea coastal area in order to assess environmental quality status in that area. Four sites were selected, including two within the Gulf of Gdańsk (GoG). In biota and sediment at each site, DDTs dominated over PCBs and PBDEs were the least abundant among organic contaminants. Their concentrations decreased progressively outward from GoG. Among metal contaminants, the levels of Hg, Pb, and Cd were elevated in GoG. Biomarkers in flounder, EROD activity and DNA SB, showed moderate positive correlations with organic and metal contaminants. In flounder, the integrated biomarker index (IBR/n) presented a spatial trend coherent with chemical pollution index (CPI), but there was no clear spatial correspondence between IBR/n and CPI in mussels nor between sediment toxicity index (STI) and sediment CPI. The integrated assessment of contaminant and biological effect data against available assessment criteria indicated that in biota, the contaminant assessment thresholds were most often exceeded by CB-118, heptachlor, PBDE, and Hg (in the GoG sediments by p,p'-DDT, Hg and Cd), while of the biological determinants, the threshold was breeched by AChE activity in mussels in GoG. Applying the ICES/OSPAR traffic-light approach showed that of the 50 parameters assessed at each site, there were 18% of determinants in the red color category in the two GoG sites and 8% of determinants in the two sites outside GoG, which indicated that none of the four investigated sites attained good environmental status (GES).

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Natural variability of hepatic biomarkers in Mediterranean deep-sea organisms

Cited by 30 publications

References 65 publications

Survival, Reproduction, Avoidance Behavior and Oxidative Stress Biomarkers in the Earthworm Octolasion cyaneum Exposed to Glyphosate

Survival, Reproduction, Avoidance Behavior and Oxidative Stress Biomarkers in the Earthworm Octolasion cyaneum Exposed to Glyphosate

Natural variability of biochemical biomarkers in the macro‐zoobenthos: Dependence on life stage and environmental factors

An integrated assessment of pollution and biological effects in flounder, mussels and sediment in the southern Baltic Sea coastal area

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