Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent–infant contact

Feldman, Ruth; Gordon, Ilanit; Schneiderman, Inna; Weisman, Omri; Zagoory‐Sharon, Orna

doi:10.1016/j.psyneuen.2010.01.013

Cited by 543 publications

(433 citation statements)

References 58 publications

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“…This extragenomic cross-generational transmission defines a biobehavioral feedback loop: maternal oxytocin determines the mother's caregiving behavior, which in turn shapes the infant's oxytocin through species-typical parenting behavior (8). Human studies similarly demonstrate the involvement of oxytocin in parenting behavior, particularly social synchrony and affectionate touch (9), and show that parental oxytocin influences the infant's oxytocin system through the provision of synchronous parenting (10). Oxytocin administration to a parent increases salivary oxytocin production and social engagement in parent and child (11), and synchronous mothers display greater brain activations in response to infant stimuli in oxytocin-rich brain areas (12).…”

Section: Discussionmentioning

confidence: 99%

“…The recent surge of studies highlighting its involvement in attachment and sociocognitive processes indicates that humans, like other mammals, learn to function within their ecosocial niche on the basis of biobehavioral experiences occurring within the mother-infant bond (6). Oxytocin is among the systems most sensitive to epigenetic effects and is shaped in postnatal life through patterns of maternal care (9,10). Such an environment-sensitive birthrelated system is a natural candidate as an underlying mechanism of maternal depression.…”

Section: Discussionmentioning

confidence: 99%

“…The families were visited at home in the afternoon or evening to control for diurnal variability in oxytocin (9), and each visit lasted approximately 4 hours.…”

Section: Psychopathology In Family Membersmentioning

confidence: 99%

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Impact of Maternal Depression Across the First 6 Years of Life on the Child’s Mental Health, Social Engagement, and Empathy: The Moderating Role of Oxytocin

Apter-Levy¹,

Feldman²,

Vakart³

et al. 2013

AJP

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225

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Objective: Maternal depression across the postbirth period has long-term negative consequences for infant development. Little is known of the neurobiological underpinnings, but they could involve oxytocin, a neuropeptide that is dysfunctional in depression and is implicated in birth and parenting.Method: The authors recruited a community cohort of women with high or low depression scores 2 days after childbirth and measured depression again at 6 and 9 months. When the child was 6, the authors evaluated the families of 46 chronically depressed mothers and 103 mothers reporting no depression since childbirth. The child was assessed for psychiatric diagnoses, social engagement, and empathy. Mother, father, and child were tested for salivary oxytocin level and variation in the rs2254298 single nucleotide polymorphism on the OXTR gene.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of Maternal Depression Across the First 6 Years of Life on the Child’s Mental Health, Social Engagement, and Empathy: The Moderating Role of Oxytocin

Apter-Levy¹,

Feldman²,

Vakart³

et al. 2013

AJP

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225

185

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“…For example, experience during ontogeny has been shown to have an enduring effect on behavior, and the oxytocin system (sensitivity to this neurohormone) might also be modulated through epigenetic effects (Kumsta et al, 2013;Apter-Levy et al, 2013;Feldman et al, 2010). Indeed, subjects of the two breeds included in the present study differed in some aspects of their socialization background (see in Subjects section and Table S1).…”

Section: Discussionmentioning

confidence: 99%

Differential effects of oxytocin on social sensitivity in two distinct breeds of dogs ( Canis familiaris )

Kovács

Kis

Pogány

et al. 2016

Psychoneuroendocrinology

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Please cite this article as: {http://dx.doi.org/This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Effects of oxytocin on social sensitivity in two breeds of dogs Kovács et al. HighlightsBreed-specific effects of oxytocin on dogs' social responsiveness were found Genetic and epigenetic factors might contribute to differential oxytocin effects Border Collies are more human oriented than Siberian Huskies Oxytocin affects some social behaviors irrespective of breed Sex differences can be found in the effect of oxytocin on dogs Effects of oxytocin on social sensitivity in two breeds of dogs Kovács et al. 3 ABSTRACTDogs have been proven to show several human-analogue social behaviors, and recent research raises the possibility that the oxytocin system is related to these. However, despite dogs' general tendency to excel in the domain of social cognition, there is increasing evidence that dogs' ability to utilize human signals may vary with breed. Moreover, breeds may show differences not only in their ‗inborn' communicative abilities, but also in their learning skills related to these. The aim of the present study was to explore breed differences and breedspecific effects of oxytocin administration on different aspects of social responsiveness. Dogs from two markedly different breeds, Border Collies (cooperative workers) and Siberian Huskies (independent workers) were tested. After having received intranasal administration of oxytocin or placebo, subjects participated in three behavioral tests measuring social responsiveness. Our results show that there are several behavioral differences between the two breeds and also that there are differential effects of the oxytocin treatment. Border Collies were in general more susceptible to the ‗social' effects of oxytocin compared to Siberian Huskies: after oxytocin administration they (1) looked more at the experimenter in the ‗Unreachable food' situation, (2) looked more at the owner and shifted their gaze more between the sound source and the owner in a potentially dangerous situation, and (3) looked longer at the experimenter's eyes in the ‗Tolerance of prolonged eye contact' test. These findings suggest that selection for enhanced cooperative abilities, possibly complemented by the effect of different social environments the two breeds experience, affects dogs' performance in several behavioral tests and that the neurohormonal background differently modulates social behavior in different working breeds. KeywordsEffects of oxytocin on social sensitivity in two breeds of dogs Kovács et al. 4Oxytocin; Dog (Canis familiaris); Breed differences; Social responsiveness E...

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“…Given recent discoveries regarding associations between peripheral levels of OT and social behavior (24)(25)(26), we explored how changes in peripheral OT are associated with changes in brain activity.…”

mentioning

confidence: 99%

Oxytocin enhances brain function in children with autism

Gordon

Wyk

Bennett

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Following intranasal administration of oxytocin (OT), we measured, via functional MRI, changes in brain activity during judgments of socially (Eyes) and nonsocially (Vehicles) meaningful pictures in 17 children with high-functioning autism spectrum disorder (ASD). OT increased activity in the striatum, the middle frontal gyrus, the medial prefrontal cortex, the right orbitofrontal cortex, and the left superior temporal sulcus. In the striatum, nucleus accumbens, left posterior superior temporal sulcus, and left premotor cortex, OT increased activity during social judgments and decreased activity during nonsocial judgments. Changes in salivary OT concentrations from baseline to 30 min postadministration were positively associated with increased activity in the right amygdala and orbitofrontal cortex during social vs. nonsocial judgments. OT may thus selectively have an impact on salience and hedonic evaluations of socially meaningful stimuli in children with ASD, and thereby facilitate social attunement. These findings further the development of a neurophysiological systems-level understanding of mechanisms by which OT may enhance social functioning in children with ASD.A utism spectrum disorder (ASD) is a common, early-onset neurodevelopmental disorder characterized by devastating difficulties in social interaction, communication, and repetitive or restricted interests and behaviors. ASD displays great phenotypic heterogeneity and etiological diversity, but its original characterization, social dysfunction, has been its hallmark and unifying feature (1). There is no established pharmacological treatment for social impairment in ASD.When given acutely, intranasal oxytocin (OT) leads to enhanced processing of social stimuli in typically developing adults, as evidenced by increased eye contact, in-group trust, and emotion recognition from facial expressions (2-4). At the level of neural systems, intranasal OT heightens activity in a set of neuroanatomical structures involved in processing socially meaningful stimuli in typically developing adults (5, 6). Recently, the first brain imaging study in adults with ASD examined the effects of OT administration and identified increased activation in the right amygdala during social information processing (7).Behavioral studies demonstrate that in children and adults with ASD, a single administration of intranasal OT leads to increased willingness to interact socially (8), better comprehension of affective speech (9), reduced repetitive behaviors (10), increased understanding of others' mental states (11), and improved social cognition (12). Despite cautionary calls regarding the use of OT in children to treat ASD before understanding the neural mechanisms underlying OT's complex impact on behavior (13), there have been no studies on the effects of OT administration on brain activity in children. Furthermore, although there are several large-scale clinical trials currently underway (www. clinicaltrials.gov) to examine the effects of chronically administered OT in ASD, the e...

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Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent–infant contact

Cited by 543 publications

References 58 publications

Impact of Maternal Depression Across the First 6 Years of Life on the Child’s Mental Health, Social Engagement, and Empathy: The Moderating Role of Oxytocin

Impact of Maternal Depression Across the First 6 Years of Life on the Child’s Mental Health, Social Engagement, and Empathy: The Moderating Role of Oxytocin

Differential effects of oxytocin on social sensitivity in two distinct breeds of dogs ( Canis familiaris )

Oxytocin enhances brain function in children with autism

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