Natural Virucidal Compounds in Foods

Bright, Kelly R.; Gilling, Damian H.

doi:10.1007/978-3-319-30723-7_16

Cited by 13 publications

(12 citation statements)

References 85 publications

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“…However, these interactions were found to be more closely related to antagonism rather than synergism due to the strong effect of the tested components. Plant antimicrobials have antiviral action mechanisms such as direct virucidal action which reduces their ability to infect cells, inhibition of the initial stages of virus replication in the cell, inhibition of viral protein synthesis or modifications, denaturation or degradation of viral nucleic acids and antimicrobial coating of virus particles (Bright & Gilling, ).…”

Section: Discussionmentioning

confidence: 99%

Investigation of different interactions between Staphylococcus aureus phages and pomegranate peel, grape seed, and black cumin extracts

Tayyarcan

Soykut

Yilmaz

et al. 2019

Journal of Food Safety

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Today, antibiotic resistance is one of the most crucial problems so that researchers have begun to search for alternatives to antibiotics. Among these alternatives, phage therapy and phytotherapy became prominent. The present study aims to put forward a different approach by combining these two methods. For this purpose, Staphylococcus aureus phages were isolated from commercial mixtures. After that, extraction of phenolic compounds from pomegranate peels (Ps), grape seeds (GSs), and black cumin (NS) was carried out and antimicrobial activities were determined. Phage‐phenolic interactions were investigated by examining the effect of phenolic extracts on phage plaque sizes and then on phage titer and bacteria count. As a result, it was found that only the NS extract had a positive effect on phage activity and increased the size of phage plaques. However, no synergistic effect was observed in experiments performed in liquid media. It was also found that P and GS extracts inhibited phage activity. Practical Applications The present study was focused on effects of extracts obtained from pomegranate peel, grape seed, and black cumin on Staphylococcus aureus phage activity. It is known that antibiotic resistance constitutes a major obstacle to the pathogen elimination. In this study, phage therapy and phytotherapy, which are prominent methods in pathogen elimination, have been combined and the effect of phenolic compounds isolated from natural sources on phage activity and bacteria count have been examined. Given the results of the current study, it has been demonstrated that the combined use of phages and antimicrobial compounds could be an important alternative to combating pathogens. It is thought that this combined method should be taken into consideration both in the practice of phage therapy on humans and animals, and in applications in the food industry.

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Section: Discussionmentioning

confidence: 99%

Investigation of different interactions between Staphylococcus aureus phages and pomegranate peel, grape seed, and black cumin extracts

Tayyarcan

Soykut

Yilmaz

et al. 2019

Journal of Food Safety

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“…There are numerous groups of plant compounds/components that have been shown to have antimicrobial activity including saponins, thiosulfinates, glucosinolates, terpenoids, and polyphenols. Many of these have been shown to have efficacy against various enveloped viruses such as herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2), bovine herpesviruses (BHV), bovine viral diarrhea virus (BVDV), human immunodeficiency virus (HIV), dengue virus (DENV), junin virus (JUNV), yellow fever virus (YFV), human respiratory syncytial virus (HRSV), influenza A virus (INFV-A; H1N1, H3N2, H5N1, and H9N2 strains), Newcastle disease virus (NDV), viral hemorrhagic septicemia virus (VHSV), human cytomegalovirus (HCMV), and measles virus (MeV) indicating possible efficacy against coronaviruses (reviewed by Goyal and Cannon, 2006;Bright and Gilling, 2016).…”

Section: Plant-based Antimicrobialsmentioning

confidence: 99%

Biocides and Novel Antimicrobial Agents for the Mitigation of Coronaviruses

et al. 2020

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, a highly infectious and rapidly spreading new pneumonia of unknown cause was reported to the Chinese WHO Country Office. A cluster of these cases had appeared in Wuhan, a city in the Hubei Province of China. These infections were found to be caused by a new coronavirus which was given the name "2019 novel coronavirus" (2019-nCoV). It was later renamed "severe acute respiratory syndrome coronavirus 2," or SARS-CoV-2 by the International Committee on Taxonomy of Viruses on February 11, 2020. It was named SARS-CoV-2 due to its close genetic similarity to the coronavirus which caused the SARS outbreak in 2002 (SARS-CoV-1). The aim of this review is to provide information, primarily to the food industry, regarding a range of biocides effective in eliminating or reducing the presence of coronaviruses from fomites, skin, oral/nasal mucosa, air, and food contact surfaces. As several EPA approved sanitizers against SARS-CoV-2 are commonly used by food processors, these compounds are primarily discussed as much of the industry already has them on site and is familiar with their application and use. Specifically, we focused on the effects of alcohols, povidone iodine, quaternary ammonium compounds, hydrogen peroxide, sodium hypochlorite (NaOCl), peroxyacetic acid (PAA), chlorine dioxide, ozone, ultraviolet light, metals, and plant-based antimicrobials. This review highlights the differences in the resistance or susceptibility of different strains of coronaviruses, or similar viruses, to these antimicrobial agents.

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“…On the other hand, non-enveloped viruses enter the cytosol by endocytic mechanisms or directly penetrating the plasma membrane. The presence or absence of a viral envelope is likely to play a significant role in the effectiveness (or lack thereof) of the virucidal, since the exterior membranous-surface of the virus is what makes the first contact with the antiviral [ 6 ]. Moreover, host-targeting natural antivirals, which modulate cellular biological functions, can offer a broad-spectrum antiviral activity, reduced resistance phenomena but higher likelihood of toxicity [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity Exerted by Natural Products against Human Viruses

Musarra‐Pizzo

Pennisi

Ben-Amor

et al. 2021

Viruses

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Viral infections are responsible for several chronic and acute diseases in both humans and animals. Despite the incredible progress in human medicine, several viral diseases, such as acquired immunodeficiency syndrome, respiratory syndromes, and hepatitis, are still associated with high morbidity and mortality rates in humans. Natural products from plants or other organisms are a rich source of structurally novel chemical compounds including antivirals. Indeed, in traditional medicine, many pathological conditions have been treated using plant-derived medicines. Thus, the identification of novel alternative antiviral agents is of critical importance. In this review, we summarize novel phytochemicals with antiviral activity against human viruses and their potential application in treating or preventing viral disease.

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Natural Virucidal Compounds in Foods

Cited by 13 publications

References 85 publications

Investigation of different interactions between Staphylococcus aureus phages and pomegranate peel, grape seed, and black cumin extracts

Investigation of different interactions between Staphylococcus aureus phages and pomegranate peel, grape seed, and black cumin extracts

Biocides and Novel Antimicrobial Agents for the Mitigation of Coronaviruses

Antiviral Activity Exerted by Natural Products against Human Viruses

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