Naturally Available Extracts Inhibiting Cancer Progression: A Systematic Review

Abraham, Marin; Augustine, Dominic; Rao, Roopa S; Sowmya, S; Haragannavar, Vanishri C; Nambiar, Shwetha; Prasad, Kavitha; Awan, Kamran Habib; Patil, Shankargouda

doi:10.1177/2156587217744914

Cited by 9 publications

(4 citation statements)

References 51 publications

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“…The presence of low concentrations of all extracts (75 and 125 µg/mL) stimulated their metabolic activity, while, for the same concentration, the tumor cells had a decrease on their metabolic activity. Though the variability of results is high (which is common in these type of tests), this effect is statistically different and this result is in accordance with the literature, where it is described that naturally available extracts of different sources selectively inhibit abnormal cell proliferation without interrupting normally functioning cells [58]. Therefore, this finding is the ideal condition for a potential anti-cancer effect, as it would only affect the cancer cells and not the healthy cells.…”

Section: Cell Viabilitysupporting

confidence: 85%

Unravelling the Biological Potential of Pinus pinaster Bark Extracts

et al. 2020

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Natural compounds from agro-food by-products have fostered interest in food industries. The aim of this study was to unravel potential uses for Pinus pinaster bark extracts (PBE). As functional features of this type of extracts are usually attributed to phenolic compounds, the extraction process was studied. Different PBEs were achieved, with high content in phenolic compounds, using different water/ethanol combinations as a solvent. These PBEs were chemically characterized, and their bioactivity and in vitro cell viability were evaluated. Extracts obtained with hydroethanolic solvents had higher content in phenolic and flavonoid compounds. All the PBEs presented high antioxidant, antibacterial and antihyperglycemic activities. Moreover, PBEs have low cytotoxicity and a selective activity against cancer cells as these were negatively affected. These features may allow the extracts to be used in food formulation and processing (as preservatives, antioxidants or bioactive ingredients), but they showed also potential for the pharmaceutical or nutraceutical sectors.

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Section: Cell Viabilitysupporting

confidence: 85%

Unravelling the Biological Potential of Pinus pinaster Bark Extracts

et al. 2020

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“…Despite the remarkable progress in synthetic organic medicinal products of the twentieth century, over 25% of prescribed medicines in industrialized countries are derived directly or indirectly from plants 3 . The deduction from this study that the test plants used have potential to be used as anti-cancer agents because of their rich phytochemical contents is in tandem with the reports of so many researchers [15][16][17][18][19] . However, plants used in traditional medicine are still under investigation 20 .…”

Section: Discussionsupporting

confidence: 66%

Treatment of Prostate Cancer Using Indigenous Plants in Nnewi South Local Government Area

Nnajiofor,

Lilian,

Azubuike

et al. 2023

Res. J. Med. Plants

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Background and Objective: Medicinal plants are vital sources of easily accessible remedies used in the countryside healthcare system. This study aimed at determining the medicinal plants used in the treatment of prostate cancer in Unubi Nnewi South L.G.A and documentation of the various plant species used for curing diseases. Materials and Methods: Ethno study on the indigenous plants used for the treatment of prostate cancer in Unubi, Nnewi South Local Government Area was carried out through oral interviews and the use of questionnaire for data collection. Plant samples with their leaves, fruits, flowers, stems, barks and roots were collected and used for the interview. The common and vernacular names of the described species were also of interest and standard literature were then consulted for their proper identification. Results: The highest number of questionnaires 60 was retrieved from Amakobam village and the least 40 was obtained from Etitinabo village. The respondents showed that they got access to information on the plants species used for the treatment of prostate cancer through apprenticeship (93.3%) and some were informed through folklore (68.3%) while newspapers and the internet were the least sources of information about plant species relevant in the treatment of prostate cancer. The result showed that the most notable mode of preparation of herbal medicine for the treatment of prostate cancer was extractions and decoctions 89.2 and 75.8%, respectively. For the treatment of prostate cancer in the study area, the most frequently used plant is Talinum triangulare (85%) and Telfaria occidentalis (74%). Dennettia tripetala (40.8%), Cassia occidentalis (61%) and Spondias mombin (53%) were moderately used or rarely used. Conclusion: These plants are effective when administered properly and taken daily. Since plant species comes with many benefits like medicinal purpose, it is therefore, encouraged to consume them as food or medicine.

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“…In this study, we evidenced that P2Et and Anamú-SC plant extracts are not toxic to microenvironment BM cells such as ECs and MSC, regardless of the culture system evaluated (2D vs. 3D), as we had previously shown for other cell populations, such as fibroblasts and peripheral blood mononuclear cells [ 32 , 33 , 35 ]. In addition, plant extracts have been reported to exert their antitumor effect with lower doses than conventional chemotherapeutics [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Doxorubicin Activity Is Modulated by Traditional Herbal Extracts in a 2D and 3D Multicellular Sphere Model of Leukemia

et al. 2023

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The modulation of the tumor microenvironment by natural products may play a significant role in the response of tumor cells to chemotherapy. In this study, we evaluated the effect of extracts derived from P2Et (Caesalpinia spinosa) and Anamú-SC (Petiveria alliacea) plants, previously studied by our group, on the viability and ROS levels in the K562 cell line (Pgp− and Pgp+), endothelial cells (ECs, Eahy.926 cell line) and mesenchymal stem cells (MSC) cultured in 2D and 3D. The results show that: (a) the two botanical extracts are selective on tumor cells compared to doxorubicin (DX), (b) cytotoxicity is independent of the modulation of intracellular ROS for plant extracts, unlike DX, (c) the interaction with DX can be influenced by chemical complexity and the expression of Pgp, (d) the 3D culture shows a greater sensitivity of the tumor cells to chemotherapy, in co-treatment with the extracts. In conclusion, the effect of the extracts on the viability of leukemia cells was modified in multicellular spheroids with MSC and EC, suggesting that the in vitro evaluation of these interactions can contribute to the comprehension of the pharmacodynamics of the botanical drugs.

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Naturally Available Extracts Inhibiting Cancer Progression: A Systematic Review

Cited by 9 publications

References 51 publications

Unravelling the Biological Potential of Pinus pinaster Bark Extracts

Unravelling the Biological Potential of Pinus pinaster Bark Extracts

Treatment of Prostate Cancer Using Indigenous Plants in Nnewi South Local Government Area

Doxorubicin Activity Is Modulated by Traditional Herbal Extracts in a 2D and 3D Multicellular Sphere Model of Leukemia

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