Naturally derived biofunctional nanofibrous scaffold for skin tissue regeneration

Suganya, S.; Venugopal, Jayarama Reddy; Ramakrishna, Seeram; Lakshmi, Baddireddi Subhadra; Dev, V. R. Giri

doi:10.1016/j.ijbiomac.2014.04.031

Cited by 67 publications

(34 citation statements)

References 35 publications

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“…The surface roughness (R a ) of pure polysulfone was found to be 2.22, and the 1, 2 and 5 wt % loading of hydroxyapatite fillers were found to be 3.85, 4.97 and 7.80, respectively; our results show similar roughness levels [44]. It was reported that bone implant with enhanced roughness has a significant influence on the adhesion and proliferation of osteoblasts [40], hence our Aloe vera dip-coated mPE-nHA with enhanced roughness might be suitable for the bone tissue engineering.…”

Section: Resultssupporting

confidence: 73%

“…Finally, the peak at 714 cm −1 represents the C-H bend of the aromatic and alkyne group, respectively. In spite of there being no major change in the functional groups, the Aloe vera dip-coated mPE-nHA nanocomposite samples demonstrated characteristic absorption spectrum of Aloe vera at 1731 and 1232 cm −1 , elucidating the presence of O-acetyl esters; the peaks formed at 1469 cm −1 and 714 cm −1 unravelled the essence of the aromatic vibrations of the components present in Aloe vera gel [39,40]. In the interim, the Aloe vera dip-coated samples were also found to have peak shifts at far regions of the IR spectra ("Zone A"), which shown in Figure 3b.…”

Section: Resultsmentioning

confidence: 99%

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Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

et al. 2017

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Bone tissue engineering widely explores the use of ceramic reinforced polymer-matrix composites. Among the various widely-used ceramic reinforcements, hydroxyapatite is an undisputed choice due to its inherent osteoconductive nature. In this study, a novel nanocomposite comprising metallocene polyethylene (mPE) incorporated with nano-hydroxyapaptite nanorods (mPE-nHA) was synthesized and dip coated with Aloe vera after subjecting it to microwave treatment. The samples were characterized using contact angle, Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), atomic force microscopy (AFM) and 3D Hirox microscopy scanning. Contact angle results show that the hydrophilicity of mPE-nHA improved notably with the coating of Aloe vera. The surface topology and increase in surface roughness were observed using the SEM, AFM and 3D Hirox microscopy. Blood compatibility assays of pure mPE and the Aloe vera coated nanocomposite were performed. The prothrombin time (PT) was delayed by 1.06% for 24 h Aloe-vera-treated mPE-nHA compared to the pristine mPE-nHA. Similarly, the 24 h Aloe-vera-coated mPE-nHA nanocomposite prolonged the activated partial thromboplastin time (APTT) by 41 s against the control of pristine mPE-nHA. The hemolysis percentage was also found to be the least for the 24 h Aloe-vera-treated mPE-nHA which was only 0.2449% compared to the pristine mPE-nHA, which was 2.188%. To conclude, this novel hydroxyapatite-reinforced, Aloe-vera-coated mPE with a better mechanical and anti-thrombogenic nature may hold a great potential to be exploited for bone tissue engineering applications.

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Section: Resultssupporting

confidence: 73%

Section: Resultsmentioning

confidence: 99%

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

et al. 2017

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“…The recorded FTIR spectrum is displayed in Figure 2( 8,11 Meanwhile, the Aloe vera-coated substrates were also observed to possess shifts in the peaks at far regions of the IR spectra (,600 cm…”

Section: Physicochemical Characterization Studiesmentioning

confidence: 99%

“…This significant improvement is suspected to be due to the water-loving constituents present in Aloe vera gel, and it correlates with the results of previous studies. 8,11 As mentioned earlier, Aloe vera is a natural store house of several polysaccharides, minerals, vitamins, amino acids, and proteins that are basically hydrophilic. The recorded contact angle falls in the optimum range of 70°-30°, which has previously been reported in several works 37,38 of research.…”

Section: Contact Angle Measurementmentioning

confidence: 99%

“…[4][5][6][7] Recent works reported on the use of Aloe vera in the synthesis of modern materials such as nanoparticles, nanocomposites, and nanofibers have proved its importance in the field of wound healing, tissue regeneration, and cancer drug delivery. [8][9][10][11][12][13] Inspired by its profound background, in this work, the extract obtained from Aloe vera is utilized to develop an antifouling and biocompatible material for multipurpose biomedical implants for tissue engineering applications.…”

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confidence: 99%

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Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications

Balaji¹,

Jaganathan²,

Supriyanto³

et al. 2015

IJN

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Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera , a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera -induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera -glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants.

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Advances in Skin Regeneration: Application of Electrospun Scaffolds

Norouzi

Boroujeni

Omidvarkordshouli

et al. 2015

Adv Healthcare Materials

242

182

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The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin substitutes and wound dressings. Furthermore, the application of biomolecules and therapeutic agents in the nanofibrous scaffolds viz growth factors, genes, antibiotics, silver nanoparticles, and natural medicines with the aim of ameliorating cellular behavior, wound healing, and skin regeneration are discussed.

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Naturally derived biofunctional nanofibrous scaffold for skin tissue regeneration

Cited by 67 publications

References 35 publications

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications

Advances in Skin Regeneration: Application of Electrospun Scaffolds

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