Naturally enriched 13C breath test as a carbohydrate intake marker in obese women

Beato, Gabriel Cunha; Ravelli, Michele Novaes; Sartori, Maria Márcia Pereira; Oliveira, Maria Rita Marques de

doi:10.1186/s41110-020-00119-z

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Children who respond to sapropterin dihydrochloride treatment had increased 13 CO 2 production from 1- 13 C-phenylalanine, suggesting improved phenylalanine hydroxylase activity [ 43 ]. Similarly, the use of naturally enriched 13 C-breath tests to measure starch absorption in healthy populations [ 23 ], in obese women [ 44 ], and in patients with pancreatic disease [ 32 ], has been described before. Our current study adds to this literature with a focus on a breath test in GSD patients to benefit their dietary management.…”

Section: Discussionmentioning

confidence: 99%

Development of minimally invasive 13C-glucose breath test to examine different exogenous carbohydrate sources in patients with glycogen storage disease type Ia

Turki

Stöckler

Sirrs

et al. 2022

Molecular Genetics and Metabolism Reports

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Section: Discussionmentioning

confidence: 99%

Development of minimally invasive 13C-glucose breath test to examine different exogenous carbohydrate sources in patients with glycogen storage disease type Ia

Turki

Stöckler

Sirrs

et al. 2022

Molecular Genetics and Metabolism Reports

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The Breath Carbon Isotope Ratio Reflects Short-term Added-Sugar Intake in a Dose-Response, Crossover Feeding Study of 12 Healthy Adults

O’Brien

Niles

Black

et al. 2021

The Journal of Nutrition

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Background Objective dietary biomarkers are urgently needed for a wider range of foods and nutrients. The breath carbon isotope ratio (CIR; measured as δ13C values) has potential as a noninvasive measure of short-term added sugar (AS) intake but has not been evaluated in a controlled-feeding study. Objective The aim was to evaluate the effect of short-term AS intake on breath CIR in a dose-response, randomized, crossover feeding study. Methods Six men and 6 women, aged 25 to 60 y, were randomly assigned to a balanced sequence of 5 dietary treatments. Three treatments delivered low (0 g/d), medium (75 g/d), or high (150 g/d) amounts of AS over the course of a single day's breakfast and lunch and 2 switched high and low intake amounts between breakfast and lunch. Experimental meals delivered 60% of daily energy and added-sugar targets. There was a washout period of 1–2 wk between treatments. Breath was collected at 2-h intervals from 08:00 (fasting) to 16:00 h. Breath CIR was measured using cavity ring-down spectroscopy, and the effects of dietary treatments and baseline were evaluated using multivariate linear regression. Results Breath CIR showed a significant response to increasing AS intake at all sampling time points (all P < 0.0001), with a dose-response of 0.030 (95% CI: 0.024, 0.037) ‰/g. Fasting breath CIR (baseline) influenced postfeeding breath CIR at all sampling time points (P < 0.0001); however, effect sizes were largest in the morning. For afternoon-collected samples (14:00 and 16:00), the effect of recent AS intake (lunch) was 4-fold greater than the effect of previous added-sugar intake (breakfast). Conclusions These findings support the potential of the breath CIR as a biomarker of short-term AS intake in healthy US adults. More work is needed to evaluate other potential dietary effects and whether multiple breath collections could capture daily AS intake.

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Naturally enriched 13C breath test as a carbohydrate intake marker in obese women

Cited by 2 publications

References 18 publications

Development of minimally invasive 13C-glucose breath test to examine different exogenous carbohydrate sources in patients with glycogen storage disease type Ia

Development of minimally invasive 13C-glucose breath test to examine different exogenous carbohydrate sources in patients with glycogen storage disease type Ia

The Breath Carbon Isotope Ratio Reflects Short-term Added-Sugar Intake in a Dose-Response, Crossover Feeding Study of 12 Healthy Adults

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