Exploring Chemistry With Pyridine Derivatives 2023
DOI: 10.5772/intechopen.106663
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Naturally Isolated Pyridine Compounds Having Pharmaceutical Applications

Abstract: Heterocyclic moieties form important constituents of biologically active natural products and synthetic compounds of medicinal interest. Nitrogen heterocycles constitute important pharmacophores in drug design, especially pyridine derivatives, which are among the most frequently cited heterocyclic compounds. The isolated as well as synthesized pyridine compounds exhibited various pharmacological properties due to their diverse physiochemical properties like water solubility, weak basicity, chemical stability, … Show more

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“…Pyridine is a privileged N-heterocyclic scaffold found in the structures of many natural products and biologically active compounds. Their significance in terms of clinical applications has been demonstrated by their consistent incorporation into a variety of drug candidates. , Among pyridine-containing natural products, those with N-substituted pyridinium moieties have mainly been isolated from marine organisms, especially sponges, , with the 1,3-dialkylpyridinium scaffold most frequently found in sponge metabolites; monomeric and di- or trimeric pyridinium derivatives ,, and polymers have been reported. Agelongine and trigonelline are also 1,3-disubstituted derivatives that contain carboxylate substituents at C-3 instead of alkyl chains derived from fatty acids. , The spongidines have unique structures in which the D-ring of the scalarane scaffold is substituted with a pyridinium .…”
mentioning
confidence: 99%
“…Pyridine is a privileged N-heterocyclic scaffold found in the structures of many natural products and biologically active compounds. Their significance in terms of clinical applications has been demonstrated by their consistent incorporation into a variety of drug candidates. , Among pyridine-containing natural products, those with N-substituted pyridinium moieties have mainly been isolated from marine organisms, especially sponges, , with the 1,3-dialkylpyridinium scaffold most frequently found in sponge metabolites; monomeric and di- or trimeric pyridinium derivatives ,, and polymers have been reported. Agelongine and trigonelline are also 1,3-disubstituted derivatives that contain carboxylate substituents at C-3 instead of alkyl chains derived from fatty acids. , The spongidines have unique structures in which the D-ring of the scalarane scaffold is substituted with a pyridinium .…”
mentioning
confidence: 99%