Naturally Occurring Chromone Glycosides: Sources, Bioactivities, and Spectroscopic Features

Amen, Yhiya; Elsbaey, Marwa; Othman, Ahmed; Sallam, Mahmoud M.; Shimizu, Kuniyoshi

doi:10.3390/molecules26247646

Cited by 24 publications

(15 citation statements)

References 146 publications

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“…Glycosides are used in cosmetic preparations to treat hyperpigmentation induced by UV radiation, owing to their role in the inhibition of tyrosinase enzyme. Amen et al (2021) alluded that those significant biological activities, including antiviral, anti-inflammatory, antitumor and antimicrobial activities, have been discovered for chromone glycosides, suggesting their potential as drug leads.…”

Section: Resultsmentioning

confidence: 99%

Pytochemical profile of Aloe ferox Mill. across different regions within South Africa

Goge

Singh

Komoreng

et al. 2023

JOMPED

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Background: Aloe ferox is an indigenous medicinal plant that is widely used for its various medicinal and pharmacological properties. Despite the medicinal importance and various applications of the species, it is surprising that little is known about the extent of geographical differences in its major chemical compounds. Also, the correlation between different geographic regions and variations in plant phytochemicals has received less attention.Aim: This study sought to investigate the presence of biologically active compounds in the leaf extracts of A. ferox from different geographical regions across South Africa.Setting: This study was set in different regions within South Africa.Methods: Phytochemical screening was performed qualitatively using established standard procedures involving chemical reagents such as hexane, chloroform and methanol and a series of reactions to determine the presence of phytocompounds of biological importance.Results: The study revealed that A. ferox leaves possess several classes of phytocompounds such as alkaloids, tannins, terpenoids, glycosides, phenolics, flavonoids, saponins and fixed oils and fats across various samples. Mucilage was absent across the samples.Conclusion: The study revealed eight classes of phytochemical compounds present on A. ferox leaves in three different geographic regions, which is consistent with the previous studies; however, further research is needed to enhance the study through qualitative research, gas chromatography–mass spectrometry and high-performance liquid chromatography analyses to validate phytochemical variations and their therapeutic effects.Contribution: This study contributes to the existing knowledge of the therapeutic Aloe genus.

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Section: Resultsmentioning

confidence: 99%

Pytochemical profile of Aloe ferox Mill. across different regions within South Africa

Goge

Singh

Komoreng

et al. 2023

JOMPED

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“…Claisen cyclization of the polyketide precursor affords the aromatic rings by enzymatic route catalyzed by polyketide reductase (PKR), and O -heterocyclic rings are formed in the next steps (enolization, Michael-type nucleophilic attack, etc.). The connection of the aromatic parts with GDP includes C-alkylation, oxidative clavage, cyclization and lactonization Figure shows the putative biogenetic pathway proposed for the main structural types of the isolated compounds represented by 6 , 9 and 11 .…”

Section: Discussionmentioning

confidence: 99%

Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives

et al. 2023

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Eight previously undescribed chromones, named pauciflorins F–M and two 5-methyl-2,4-chromadione derivatives named as pauciflorins N and O, were isolated from the methanol extract of the leaves of Centrapalus pauciflorus (Willd.) H.Rob. together with the known (+)-spiro-ethuliacoumarin. The structures were determined via extensive spectroscopic analyses, including HRESIMS, 1D NMR (1H, 13C JMOD), and 2D NMR (HSQC, HMBC, 1H–1H COSY, and NOESY) experiments. Through an MTT assay, seven isolated compounds were tested for their antiproliferative properties against human adherent breast (MCF-7, MDA-MB-231), cervical (HeLa, SiHa), and ovarian (A2780) cancer cell lines. Pauciflorin F was effective against MCF-7 breast cancer cells, its activity (IC50 5.78 μM) was comparable to that of the reference agent cisplatin (IC50 5.78 μM).

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“…Chromones and chromanones are widely distributed in many plant genera and, to a lesser extent, in some fungal species and other natural sources. 4 A large number of chromone-based compounds have been isolated from natural sources. 4,17−19 However, throughout this review emphasis is given to the novel chromones and chromanones isolated for the first time from natural sources (Table 1).…”

Section: Chromones and Chromanones From Natural Sourcesmentioning

confidence: 99%

“…4 Plants and fungi are the source of some of the most important drugs presently used in clinic, including some so chemically complex that they may never have been discovered without natural product research. 4 Thus, scientific evaluation of plants and fungi for their medicinal or other uses is fundamental to increase our armory against global health challenges. 5−7 Chromones (4H-chromen-4-ones, 4H-1-benzopyran-4-ones, or benzo-γ-pyrones) and chromanones (4-chromanones, chroman-4-ones, or 2,3-dihydro-1-benzopyran-4-one) constitute an important class of oxygen-containing heterocyclic compounds that are ubiquitous in nature (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Biological and Medicinal Properties of Natural Chromones and Chromanones

Gaspar,

Garrido,

Borges

et al. 2024

ACS Omega

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Emerging threats to human health require a concerted effort to search for new treatment therapies. One of the biggest challenges is finding medicines with few or no side effects. Natural products have historically contributed to major advances in the field of pharmacotherapy, as they offer special characteristics compared to conventional synthetic molecules. Interest in natural products is being revitalized, in a continuous search for lead structures that can be used as models for the development of new medicines by the pharmaceutical industry. Chromone and chromanones are recognized as privileged structures and useful templates for the design of diversified therapeutic molecules with potential pharmacological interest. Chromones and chromanones are widely distributed in plants and fungi, and significant biological activities, namely antioxidant, anti-inflammatory, antimicrobial, antiviral, etc., have been reported for these compounds, suggesting their potential as lead drug candidates. This review aims to update the literature published over the last 6 years (2018–2023) regarding the natural occurrence and biological activity of chromones and chromanones, highlighting the recent findings and the perspectives that they hold for future research and applications namely in health, cosmetic, and food industries.

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Naturally Occurring Chromone Glycosides: Sources, Bioactivities, and Spectroscopic Features

Cited by 24 publications

References 146 publications

Pytochemical profile of Aloe ferox Mill. across different regions within South Africa

Pytochemical profile of Aloe ferox Mill. across different regions within South Africa

Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives

Biological and Medicinal Properties of Natural Chromones and Chromanones

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