Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation

Liu, Elaine; Lewis, Kevin; Alsaffar, Hiba; Krall, Catherine M.; Singh, Anju; Kulchitsky, Vladimir A.; Corrigan, Joshua J.; Simons, Christopher T.; Petersen, Scott R.; Musteata, Florin Marcel; Bakshi, Chandra Shekhar; Romanovsky, Andrej A.; Sellati, Timothy J.; Steiner, Alexandre A.

doi:10.1152/ajpregu.00023.2012

Cited by 97 publications

(119 citation statements)

References 64 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…At least in some cases, the increased survival was coupled with a suppressed surge in ALT. 75 Whereas markers of hepatocyte damage were affected by hyperbilirubinemia in the present study, markers of renal disfunction (BUN and creatinine) were not (Fig. 3), thus suggesting the lack of tissue protection in the kidneys.…”

Section: Hyperbilirubinemia Attenuates Lps-induced Hepatic Damage In contrasting

confidence: 48%

“…71 It involves cold-seeking behavior 42,72,73 and is thought to be aimed at decreasing the metabolic requirements of tissues. 3,71 In our studies, 74,75 when rats were either allowed to select their preferred low T a or maintained at a lower T a chosen by the investigators during endotoxin shock or Escherichia coli infection, their survival rates increased. At least in some cases, the increased survival was coupled with a suppressed surge in ALT.…”

Section: Hyperbilirubinemia Attenuates Lps-induced Hepatic Damage In mentioning

confidence: 73%

See 1 more Smart Citation

Hyperbilirubinemia exaggerates endotoxin-induced hypothermia

et al. 2015

View full text Add to dashboard Cite

Systemic inflammation is accompanied by an increased production of reactive oxygen species (ROS) and by either fever or hypothermia (or both). To study aseptic systemic inflammation, it is often induced in rats by the intravenous administration of bacterial lipopolysaccharide (LPS). Knowing that bilirubin is a potent ROS scavenger, we compared responses to LPS between normobilirubinemic Gunn rats (heterozygous, asymptomatic; J/C) and hyperbilirubinemic Gunn rats (homozygous, jaundiced; J/J) to establish whether ROS mediate fever and hypothermia in aseptic systemic inflammation. These two genotypes correspond to undisturbed versus drastically suppressed (by bilirubin) tissue accumulation of ROS, respectively. A low dose of LPS (10 mg/kg) caused a typical triphasic fever in both genotypes, without any intergenotype differences. A high dose of LPS (1,000 mg/kg) caused a complex response consisting of early hypothermia followed by late fever. The hypothermic response was markedly exaggerated, whereas the subsequent fever response was strongly attenuated in J/J rats, as compared to J/C rats. J/J rats also tended to respond to 1,000 mg/ kg with blunted surges in plasma levels of all hepatic enzymes studied (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase), thus suggesting an attenuation of hepatic damage. We propose that the reported exaggeration of LPS-induced hypothermia in J/J rats occurs via direct inhibition of nonshivering thermogenesis by bilirubin and possibly via a direct vasodilatatory action of bilirubin in the skin. This hypothermiaexaggerating effect might be responsible, at least in part, for the observed tendency of J/J rats to be protected from LPS-induced hepatic damage. The attenuation of the fever response to 1,000 mg/kg could be due to either direct actions of bilirubin on thermoeffectors or the ROS-scavenging action of bilirubin. However, the experiments with 10 mg/kg strongly suggest that ROS signaling is not involved in the fever response to low doses of LPS.

show abstract

Section: Hyperbilirubinemia Attenuates Lps-induced Hepatic Damage In contrasting

confidence: 48%

Section: Hyperbilirubinemia Attenuates Lps-induced Hepatic Damage In mentioning

confidence: 73%

Hyperbilirubinemia exaggerates endotoxin-induced hypothermia

et al. 2015

View full text Add to dashboard Cite

show abstract

“…However, hypothermia may have positive effects on other aspects of pathophysiology independent of the thermal environment for the pathogen. For example, Liu et al (2012) found that rats that developed a ca. 2°C hypothermia after inoculation with severe doses of septic or aseptic endotoxins showed suppressed leakage of endotoxins into the bloodstream and reduced levels of visceral organ dysfunction, both of which probably contributed to lower mortality in hypothermic subjects.…”

Section: A Trade-off Between Foraging and Immune Function?mentioning

confidence: 99%

“…Hypothermia would be favoured when resources are scarce and the energetic costs of a fever response cannot be supported (Romanovsky and Székely, 1998). This can be the case during very severe infections or in energetically demanding environments (Liu et al, 2012), or in cases where insufficient body insulation and/or small body size precludes any sustained increase in body temperature (such as in neonates) because the resultant heat loss would be detrimental (Jones et al, 1983;Frafield and Kaplanski, 1998).…”

Section: Introductionmentioning

confidence: 99%

Body temperature changes during simulated bacterial infection in a songbird: fever at night and hypothermia at day

Sköld-Chiriac

Nord

Tobler

et al. 2015

Journal of Experimental Biology

View full text Add to dashboard Cite

Although fever (a closely regulated increase in body temperature in response to infection) typically is beneficial, it is energetically costly and may induce detrimentally high body temperatures. This can increase the susceptibility to energetic bottlenecks and risks of overheating in some organisms. Accordingly, it could be particularly interesting to study fever in small birds, which have comparatively high metabolic rates and high, variable body temperatures. We therefore investigated two aspects of fever and other sickness behaviours (circadian variation, dose dependence) in a small songbird, the zebra finch. We injected lipopolysaccharide (LPS) at the beginning of either the day or the night, and subsequently monitored body temperature, body mass change and food intake for the duration of the response. We found pronounced circadian variation in the body temperature response to LPS injection, manifested by (dose-dependent) hypothermia during the day but fever at night. This resulted in body temperature during the peak response being relatively similar during the day and night. Day-tonight differences might be explained in the context of circadian variation in body temperature: songbirds have a high daytime body temperature that is augmented by substantial heat production peaks during activity. This might require a trade-off between the benefit of fever and the risk of overheating. In contrast, at night, when body temperature is typically lower and less variable, fever can be used to mitigate infection. We suggest that the change in body temperature during infection in small songbirds is context dependent and regulated to promote survival according to individual demands at the time of infection.

show abstract

“…Liu et al [20] showed that, despite the energy cost to the animal, in systemic inflammation induced by LPS or E. coli, hypothermia is more advantageous than fever because it reduces the organic dysfunction and the mortality rate.…”

Section: Discussionmentioning

confidence: 99%

Zinc Alleviates Lipopolysaccharide Interference with Both Body Temperature and Sickness Behavior in Virgin Female Rats

Nascimento

Kirychuk

Bernardi

et al. 2018

Neuroimmunomodulation

View full text Add to dashboard Cite

Objectives: Previous studies from our group showed that lipopolysaccharide (LPS) exposure induces several signs of sickness behavior, including a decrease in food consumption, body weight gain, adipsia, and a biphasic effect in tympanic temperature with a first phase of hypothermia, followed by an increased tympanic temperature. LPS can activate a chain of nonspecific host responses, including the immune response, and decreased zinc levels. In addition, there are differences in the immune response between males and females, particularly fever, with sex hormones interfering with body temperature. This study aims to characterize the effects of zinc treatment on tympanic temperature, body weight gain, food and water consumption, and general activity in open field of virgin female rats exposed to a dose of LPS that was previously reported to induce sickness behavior. Methods: Virgin female Wistar rats were treated with either saline (S) or LPS. One hour later, the S group received another injection of saline (S + S group), half of the LPS group received saline (LPS + S group) and the other half received zinc (LPS + Zn group). Tympanic temperature, body weight, and water and food consumption were measured for 96 h. Measurements and observations started 2 h after LPS administration. Results: Treatment with zinc attenuated LPS-increased temperature, decreased the body weight gain and food consumption, and water consumption was increased. Conclusion: Zinc treatment is beneficial as it reduces the increased tympanic temperature induced by LPS, but it does not influence other sickness behavior caused by exposure to LPS.

show abstract

Naturally occurring hypothermia is more advantageous than fever in severe forms of lipopolysaccharide- and Escherichia coli-induced systemic inflammation

Cited by 97 publications

References 64 publications

Hyperbilirubinemia exaggerates endotoxin-induced hypothermia

Hyperbilirubinemia exaggerates endotoxin-induced hypothermia

Body temperature changes during simulated bacterial infection in a songbird: fever at night and hypothermia at day

Zinc Alleviates Lipopolysaccharide Interference with Both Body Temperature and Sickness Behavior in Virgin Female Rats

Contact Info

Product

Resources

About