Uranium beside some heavy elements contents in some rock, ground and well water samples of El-Missikat area, Eastern Desert, Egypt have been analyzed to decide the water suitability in El-Missikat area for human and animals uses. For this purpose, the uranium analysis has been performed using different techniques include UV/VIS Spectrophotometry, N 2 -Laser Fluorimetric (UA-3) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) techniques. In this work, ten different samples varied between rocks and water samples were collected from El-Missikat locality (four rock samples, three ground water samples beside three well water samples) and chemically analysed. The obtained results indicated that, the average concentrations of uranium and heavy elements (Pb and Cd) determined by ICP-MS in the water samples were higher than the recommended permissible limits. The acheived results show that, the well water has risky levels of uranium and heavy elements contents which severly impacts the health of users. The ptesent study recommends that, the well water in the Missikat area should not be used as drinking water source.