Naturally occurring T-cell-mediated antitumor immune response to LINE-1 antigens in mice that can be enhanced by vaccination and TLR5 agonist
Katerina I. Leonova,
Anatoli S. Gleiberman,
Victor Jaravine
et al.
Abstract:LINE-1 (L1) repeats, the most prevalent family of autonomous retrotransposons in mammalian genomes, encode two polypeptides: ORF1p and ORF2p. Although epigenetically repressed in healthy tissues, L1 elements often derepress in tumors, rendering L1 antigens potential targets for anticancer immunotherapy. To explore this potential, we established mouse tumor-derived cell lines expressing either ORF1p or a synthesized protein featuring projected T-cell epitopes of ORF2p, both fused with enhanced green fluorescent… Show more
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