Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries

Abstract

Tyrosinase is a copper-containing enzyme, which is widely distributed in microorganisms, animals and plants and is a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional methods to prevent tyrosinase action encourages researchers to seek new potent tyrosinase inhibitors for food and cosmetics. This article presents a study on the importance of tyrosinase, biochemical characteristics, type of inhibitions, activators from various natural sources with its clinical and industrial importance in recent prospects is discussed in this paper.

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

“…From this point, tyrosinase inhibitors have become increasingly important in medical and cosmetics industry to prevent hyperpigmentation 59 . As can be seen from Table 5, the tyrosinase inhibitory capacity (IC 50 ) of essential oil was found to be 11.03 mg/mL.…”

Antioxidant and Antimelanogenic Properties of Chestnut Flower Extract

“…27,28) Hence, tyrosinase inhibitors are applied to whitening skin in cosmetics, in agriculture, and in the food industry. 29,30) Mushroom tyrosinase is widely used as the target enzyme in screening and characterizing potential tyrosinase inhibitors. Because the mode of inhibition depends on the structures of both the substrate and the inhibitor, L-DOPA was used as the substrate in this study.…”

A Novel Inhibitor Against Mushroom Tyrosinase with a Double Action Mode and Its Application in Controlling the Browning of Potato

“…A large number of naturally occurring and synthetic compounds possessing tyrosinase inhibitory properties have been reported (Kim and Uyama 2005;Parvez et al 2007), but only a few find application because of their general limitation with regards to toxicity, activity, and stability. Hydroxypyridinones (HPOs), a class of iron chelators with high iron(III) affinity, have many applications in medicinal area.…”