Naturally Occurring Xanthones; Latest Investigations: Isolation, Structure Elucidation and Chemosystematic Significance

El-Seedi, Hesham R.; El-Ghorab, D. M. H.; El-Barbary, M. A.; Zayed, Mervat F.; Göransson, Ulf; Larsson, Sven‐Erik; Verpoorte, Robert

doi:10.2174/092986709788682056

Cited by 82 publications

(58 citation statements)

References 115 publications

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“…The third peak has a lower absorbance compared to the second peak. This result was different from the previous study, i.e 246 nm 7 . The maximum wavelength shifts were caused by several factors, such as a detector, solvents, and quality of sample preparation.…”

Section: Resultscontrasting

confidence: 99%

“…The limitations of this method were high values of the limit of detection and quantification, i.e. 2.123 ppm and 7.072 ppm, respectively 7 . In this study, we were developed the new analytical methods of α-mangostin using the HPLC with Photodiode Array (PDA) as detector due to PDA has better sensitivity compared to UV-Vis.…”

Section: Introductionmentioning

confidence: 99%

“…Xanthone is main seconder metabolite in mangosteen pericarps. α-mangostin is major xanthone in mangosteen pericarp extracts 7 . α-mangostin has many pharmacological properties such as mosquitoes larvicide, anti-bacteria, antifungal 8 , anti-cancer 9 , antioxidant 10 , anti-tuberculosis 11 , and analgesic.…”

Section: Introductionmentioning

confidence: 99%

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HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR Α-Mangostin ANALYSIS IN MANGOSTEEN PERICARP EXTRACT FOR ROUTINE ANALYSIS WITH PHOTODIODE ARRAY DETECTOR

Muchtaridi¹,

Prasetio²,

Saptarini³

et al. 2018

RJC

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The analytical methods for the standardization of α-mangostin are needed to set up a routine of a validated method for quality control of α-mangostin from Garcinia mangostana L. using HPLC methods. This study was aimed to validate the analytical method of High-Performance Liquid Chromatography (HPLC) for α-mangostin analysis with Photodiode Array (PDA). The analysis was conducted by HPLC with octadecyl silanol column, methanol and acetic acid 1% as a mobile phase and PDA detection at 243 nm. The coefficient correlation of analytical method was was 0.9999, the variation was less than 2%, LOD was 0.671 ppm, and LOQ was 2.174 ppm. The level of α-mangostin in mangosteen pericarp extract from Tasikmalaya was 8.56 ± 0.003%. The analytical method was met the validation criteria. The PDA sensitivity was 68.28% higher than UV-Vis detector.

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Section: Resultscontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR Α-Mangostin ANALYSIS IN MANGOSTEEN PERICARP EXTRACT FOR ROUTINE ANALYSIS WITH PHOTODIODE ARRAY DETECTOR

Muchtaridi¹,

Prasetio²,

Saptarini³

et al. 2018

RJC

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“…Several derivatives can also be isolated from a variety of fungi and lichens. 1 These compounds are highly diverse in their chemical structure, including simple oxygenated and prenylated substituents, or appearing as more complex frameworks as xanthonolignoids or bis-xanthones.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry

Santos

Garcia

Silva

et al. 2013

Tetrahedron Letters

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a b s t r a c tThe present study reports the electrochemical behavior of several phenolic and catecholic-substituted 2,3-diarylxanthones on a glassy carbon electrode, challenged by cyclic voltammetry at different pH values (4.0, 7.4, and 11.0). Higher pH values required lower anodic and cathodic peak voltages. The oxidation of catecholic groups occurred at lower peak potentials in a reversible and pH dependent manner. Anodic peak potentials appeared at higher pH values and were attributed to the electrochemically irreversible oxidation of the phenolic groups. The number and position of hydroxyl substituents were the determinants for the electrochemical behavior and found to correlate with the scavenging activity for reactive oxygen (ROS) and nitrogen species (RNS). A xanthone with two catechol units presented the lowest anodic potential voltage (E pa = 0.15 V) and proved to be the most effective ROS and RNS scavenger.

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“…The pharmacological properties of both natural and synthetic xanthones (e.g., anti-inflammatory, antimalarial, antioxidant, and antitumour activities) are associated to different substituents in different positions of their main core [7][8][9][10][11][12]. Aryl groups linked to xanthones are scarce in natural sources, but several publications reporting their synthesis and/or biomedical potential have been highlighted in literature and reviewed in [13].…”

Section: Introductionmentioning

confidence: 99%

2,3-Diarylxanthones as Potential Inhibitors of Arachidonic Acid Metabolic Pathways

et al. 2017

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Abstract-In response to an inflammatory stimulus, arachidonic acid (AA), the main polyunsaturated fatty acid present in the phospholipid layer of cell membranes, is released and metabolized to a series of eicosanoids. These bioactive lipid mediators of inflammation arise physiologically through the action of the enzymes 5-lipoxygenase (5-LOX) and cyclooxygenases (constitutive COX-1 and inducible COX-2). It is believed that dual inhibition of 5-LOX and COXs may have a higher beneficial impact in the treatment of inflammatory disorders rather than the inhibition of each enzyme. With this demand for new dual-acting antiinflammatory agents, a range of 2,3-diarylxanthones were tested through their ability to interact in the AA metabolism. In vitro anti-inflammatory activity was evaluated through the inhibition of 5-LOX-catalyzed leukotriene B 4 (LTB 4 ) formation in human neutrophils and inhibition of COX-1-and COX-2-catalyzed prostaglandin E 2 (PGE 2 ) formation in human whole blood. The results showed that some of the studied arylxanthones were able to prevent LTB 4 production in human neutrophils, in a concentration-dependent manner. The xanthone with a 2-catechol was the most active one (IC 50 ∼ 9 μM). The more effective arylxanthones in preventing COX-1-catalyzed PGE 2 production presented IC 50 values from 1 to 7 μM, exhibiting a structural feature with at least one non-substituted aryl group. All the studied arylxanthones were ineffective to prevent the formation of PGE 2 catalyzed by COX-2, up to the maximum concentration of 100 μM. The ability of the tested 2,3-diarylxanthones to interact with both 5-LOX and COX-1 pathways constitutes an important step in the research of novel dual-acting anti-inflammatory drugs.

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Naturally Occurring Xanthones; Latest Investigations: Isolation, Structure Elucidation and Chemosystematic Significance

Cited by 82 publications

References 115 publications

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR Α-Mangostin ANALYSIS IN MANGOSTEEN PERICARP EXTRACT FOR ROUTINE ANALYSIS WITH PHOTODIODE ARRAY DETECTOR

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR Α-Mangostin ANALYSIS IN MANGOSTEEN PERICARP EXTRACT FOR ROUTINE ANALYSIS WITH PHOTODIODE ARRAY DETECTOR

Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry

2,3-Diarylxanthones as Potential Inhibitors of Arachidonic Acid Metabolic Pathways

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