Nature and variants of idiopathic restless legs syndrome: observations from 152 patients referred to secondary care in the UK

Holmes, Ralph E.; Tluk, S.; Metta, Vinod; Patel, Pallavi; Rao, Ravindra; Williams, Adrian J.; Chaudhuri, K. Ray

doi:10.1007/s00702-006-0614-3

Cited by 41 publications

(32 citation statements)

References 18 publications

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“…This yielded an estimated proportion of 29.6% of RLS subjects with an ESS score Ͼ10% and 22.8% with an ESS score Ͼ11. These figures are in line with results from a further three studies [31][32][33] and two of the above studies 20,30 that directly reported the percentage of RLS patients with an elevated score (Fig. 2, upper panel).…”

Section: S410 S Fulda and T C Wettersupporting

confidence: 92%

“…Twenty studies reported mean ESS values that are graphically depicted in Figure 1. Ten studies assessed the ESS in a sleep laboratory [11][12][13][14][15][16][17][18]20 or clinical population 19 with the group-average ESS scores varying from 5.9 12 to 11.9, 15 and a weighted mean ESS score of 8.2 (Ϯ 4.9 standard deviation (SD)). In eight studies [21][22][23][24][25][26][27][28] that assessed the ESS at baseline in a treatment trial, the average scores varied from 5.4 21 to 9.2 25 with a weighted average of 7.6 (Ϯ 4.5 SD).…”

Section: Are Subjects With Rls Sleepy?mentioning

confidence: 99%

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Is daytime sleepiness a neglected problem in patients with restless legs syndrome?

Fulda

Wetter

2007

Mov Disord.

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The restless legs syndrome (RLS) is a common neurological disorder of sleep/wake motor regulation that is associated with sleep disturbances. Here, we review the evidence that RLS is also associated with increased daytime sleepiness. Summarizing 26 studies that assessed sleepiness by means of the Epworth Sleepiness Scale (ESS) in untreated subjects with idiopathic RLS, we found that 20 to 25% of subjects are at an increased risk for daytime sleepiness.

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Section: S410 S Fulda and T C Wettersupporting

confidence: 92%

Section: Are Subjects With Rls Sleepy?mentioning

confidence: 99%

Is daytime sleepiness a neglected problem in patients with restless legs syndrome?

Fulda

Wetter

2007

Mov Disord.

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“…This is significantly greater than the prevalence reported in the French general population [25]. In clinical cohorts, 30% of restless legs syndrome patients complain of EDS as assessed by an ESS score of .10 [26]. In the general population, subjects with restless legs syndrome symptoms had statistically more frequent EDS.…”

Section: Prevalence Of Resmentioning

confidence: 66%

Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study

Pépin¹,

Viot-Blanc²,

Escourrou³

et al. 2009

Eur Respir J

172

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The percentage of compliant continuous positive airway pressure (CPAP)-treated apnoeic patients that continue to experience residual excessive sleepiness (RES) is unknown.RES was defined by an Epworth Sleepiness Scale (ESS) score of o11. In total, 502 patients from 37 French sleep centres using CPAP .3 h?night -1 attending their 1-yr follow-up visit were eligible. ESS and polysomnographic data as well as symptoms, quality of life, depression scores and objective CPAP compliance at 1 yr were collected. Overall, 60 patients remained sleepy on CPAP (ESS 14.3¡2.5) leading to a prevalence rate of RES of 12.0% (95% confidence interval (CI) 9.1-14.8). After having excluded associated restless leg syndrome, major depressive disorder and narcolepsy as confounding causes, the final prevalence rate of RES was 6.0% (95% CI 3.9-8.01). Patients with RES were younger and more sleepy at diagnosis. The relative risk of having RES was 5.3 (95% CI 1.6-22.1), when ESS before treatment was o11. Scores of emotional and energy Nottingham Health Profile domains were two times worse in patients with RES.As 230,000 obstructive sleep apnoea patients are currently treated in France by continuous positive airway pressure, more than 13,800 of them might suffer from residual excessive sleepiness.

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“…This is consistent with previous studies. (27). In addition, Moreira et al (2008) found that RLS is significantly associated with sleep quality, sleep disturbances, and excessive daytime sleepiness (P = 0.02) (16).…”

Section: Discussionmentioning

confidence: 96%

Is Sleep Quality Associated with Restless Legs Syndrome in Patients Suffering from Multiple Sclerosis?

et al. 2017

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Background: Restless legs syndrome (RLS) is a type of movement disorder with strong importunate movement of legs during rest or inactivity. Twitching of muscle is experienced at night that disturbs patients' sleep. This syndrome is more prevalent among patients with multiple sclerosis (MS). Hence, this study aimed to investigate the association between restless legs syndrome and sleep disturbances in patients suffering from MS. Methods: This cross-sectional study was conducted from May to September 2016 in Qazvin, Iran. Participants were 118 patients with MS referring to the multiple sclerosis association. Data were collected using a demographic questionnaire, expanded disability status scale (EDSS) to screen and assess the intensity of restless legs syndrome, and Pittsburgh sleep quality index to investigate sleep disturbance. Descriptive and inferential statistics including independent T test, 2 test, and stepwise logistic regression analysis were used for data analysis. Results: RLS was diagnosed in 56.8% of the participants. The score of sleep quality was above 6 indicating poor sleep quality in the patients. However, the mean score of PSQI was significantly higher in patients suffering from restless legs syndrome compared to

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Nature and variants of idiopathic restless legs syndrome: observations from 152 patients referred to secondary care in the UK

Abstract: This study suggests that there is considerable delay before appropriate therapy in RLS. A large number have EDS and insomnia among others, is the commonest presenting feature. Phenotypic heterogeneity may cause diagnostic difficulty.

Cited by 41 publications

References 18 publications

Is daytime sleepiness a neglected problem in patients with restless legs syndrome?

Is daytime sleepiness a neglected problem in patients with restless legs syndrome?

Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study

Is Sleep Quality Associated with Restless Legs Syndrome in Patients Suffering from Multiple Sclerosis?

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