COVID-19 has triggered a burst of international scholarship concerning the reshaping of tourism and the resetting of tourism research agendas. The aim of this paper is to tease out some implications for reorienting the African tourism research agenda from 2020 and beyond. Arguably, an appropriate African research response to COVID-19 in the context of tourism must embrace a genuine transdisciplinary approach and draw in researchers who would not, historically, have operated in the tourism space. Seven key themes are discussed namely, market confidence; dependence on international long-haul tourists; supporting regional and domestic tourism especially VFR travel; redefining communitybased tourism; informal sector resilience; climate change; and, addressing present-mindedness in African tourism scholarship.