The paper presents research findings on the development of strategies for biomimetic design, that synthesize contemporary digital technologies of analysis, design, and prototyping. The proposed methodology has been validated through three case studies of biological shells which were analyzed with digital imaging technologies (SEM) to identify biomimetic design principles. Algorithmic design tools were implemented as part of a "design by analogy" process to extract and emulate the biological design solutions, to be constructed with the use of additive manufacturing (AM). A set of design iterations was produced with incremental changes in functional design parameters to examine the technical properties of the structure through Finite Element Analysis (FEA) and mechanical testing of the physical specimens and identify trends in its mechanical performance. Within the methodology developed in this research, bidirectional loops of feedback between the different stages of biomimetic design were created. The topological characteristics and function of the biomimetic models informed the AM technology and process, as well as the FEA and testing methods. At the same time, the fabrication requirements, and constraints along with the mechanical characterization results counterinformed the biologically inspired designs. The paper presents the outcomes of this iterative optimization process, supporting the role of biomimicry for the development of efficient and sustainable design solutions that can be applied to contemporary design, responding to architectural and engineering challenges.