Nature of a white opaque substance visualized by magnifying endoscopy in colorectal hyperplastic polyps

Hirano, Akikazu; Yao, Kenshi; Ishiguro, Hiroshi; Hisabe, Takashi; Imamura, Kentaro; Kanemitsu, Takao; Ohtsu, Kensei; Hasegawa, Rino; Ikezono, Go; Takeda, Kazuhiro; Miyaoka, Masaki; Ueki, Toshiharu; Tanabe, Hiroshi; Haraoka, Seiji; Iwashita, Akinori

doi:10.1055/a-1545-0724

Cited by 2 publications

(2 citation statements)

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“…Additionally, white opaque substance (WOS) as another whitish change of colonic mucosa detected in adenoma, SSL, and hyperplastic polyps was reported and it was positive for the immunohistochemical stain of adipophilin. 32,33 However, our results showed stain of adipophilin was not consistent with positive area of WDC, thus we thought WDC was different from WOS. However, both WDC and WOS can be observed in SSL and SSLD and further analysis including endoscopic differentiation between WDC and WOS should be performed.…”

Section: Discussioncontrasting

confidence: 58%

A comparison of the diagnostic ability of magnified narrow band imaging and blue laser/light imaging for sessile serrated lesions

Kobayashi

Yoshida

Morinaga

et al. 2023

Preprint

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Purpose The diagnosis of sessile serrated lesions (SSL) and SSL with dysplasia (SSLD) using blue laser/light imaging (BLI) has not been well evaluated. We analyzed the diagnostic ability and specific endoscopic findings of BLI for SSL and SSLD compared to those of narrow band imaging (NBI). Methods We retrospectively reviewed 476 resected lesions from the cecum to the descending colon, which showing Type1 of the Japan NBI Expert Team (JNET) classification completely or partially with magnified NBI or BLI between 2014 and 2021 in our institution. The comparison of the NBI and BLI groups after matching was performed regarding the diagnostic ability of SSL and SSLD. The endoscopic findings of SSL on NBI and BLI were defined as expanded crypt opening (ECO) or thick and branched vessels (TBV) based on previous reports. Additionally, those of SSLD originally defined as network vessels (NV) and white dendritic change (WDC) were analyzed. Results After matching, the sensitivity of lesions with either ECO or TBV for diagnosing SSL and with those with either WDC or NV for diagnosing SSLD in the NBI/BLI were 97.5%/98.5% (p = 0.668) and 81.0%/88.9% (p = 0.667). Regarding the comparison of specific endoscopic findings between the SSLD and SSL, there were significant differences in WDC (66.4% vs. 8.6%, p < 0.001), NV (55.3% vs. 1.4%, p < 0.001), and either WDC or NV (86.8% vs. 9.0%, p < 0.001). Conclusions There was no difference in the diagnostic ability of NBI and BLI for SSL and SSLD. NV and WDC might be useful for diagnosing SSLD.

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Section: Discussioncontrasting

confidence: 58%

A comparison of the diagnostic ability of magnified narrow band imaging and blue laser/light imaging for sessile serrated lesions

Kobayashi

Yoshida

Morinaga

et al. 2023

Preprint

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“…In recent years, the combination of magnification imaging and electronic staining has been used by several research institutions to study the relationship between white opaque substances in gastric wall and tumor occurrence and development [4], and It is confirmed that WOS also exists in other regions of the digestive tract, including the stomach, large intestine, colorectal, duodenum and esophagus [5][6][7][8][9]. WOS is formed by the accumulation of tiny lipid droplets in the epithelium [10], which has strong reflection and scattering in visible light, so it will cover the blood vessels on the surface of the gastric mucosa. In this case, degree of lesion cannot be diagnosed according to the microvascular and microsurface patterns, but can only be judged according to the distribution and coverage of lipids [3,11,12].…”

Section: Introductionmentioning

confidence: 97%

Multispectral endoscopic imaging studies on the tissue components of gastrointestinal mucosa

Yuan²,

Wang³

2022

Advanced Optical Imaging Technologies V

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In recent years, endoscopic imaging has become the major diagnostic approach for early cancer. It is difficult to accurately obtain the information of lesions and components content by using conventional white light imaging (C-WLI). Multispectral imaging techniques such as narrowband imaging are widely used in endoscopic clinical because of their specificity on the surface structure of digestive tract mucosa. However, there is still a lack of multispectral techniques for tissue components specificity. Tissue components such as lipid, hemoglobin are closely related to the generation and development of tumors, but it is difficult to observe the characteristics of lipid and hemoglobin by conventional white light imaging. Therefore, we studied the multispectral endoscopic imaging technique for the analysis of digestive tract mucosal components. Based on the reflectance spectrum characteristics of these tissue components, we determined their specific wavelength, and comprehensively considered the absorption, scattering, oxygenation and others in order to determine the most appropriate optical band in the wavelength range of 365-660nm. Through experimental verification, we choose different narrow-band wavelength combinations for lipids and hemoglobin oxygen saturation respectively to achieve multispectral imaging. In order to simulate the optical properties of digestive tract surface, we made tissue optical phantom. At the same time, we tested and optimized the imaging system and algorithm by the experiments in vitro, and obtained the optimal multispectral image of tissue components, then realize the quantitative detection combined with the content analysis algorithm. Our pilots show that the multispectral imaging system can improve the contrast of endoscopy image, enhance the detail information, achieve high precision detection of tissue components content, and control the error within 10%.

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Nature of a white opaque substance visualized by magnifying endoscopy in colorectal hyperplastic polyps

Cited by 2 publications

References 0 publications

A comparison of the diagnostic ability of magnified narrow band imaging and blue laser/light imaging for sessile serrated lesions

A comparison of the diagnostic ability of magnified narrow band imaging and blue laser/light imaging for sessile serrated lesions

Multispectral endoscopic imaging studies on the tissue components of gastrointestinal mucosa

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