Nature of anaemia in rheumatoid arthritis. 8. Iron content of synovial tissue in patients with rheumatoid arthritis and in normal individuals.

Clearnace of Fe59-labelled erythrocytes from normal and inflamed rabbit knee joints. I. Relationship to the anaemia of rheumatoid arthritis.

“…A fault in the release of iron from storage sites and in particular the synovium has been discussed as an important contributing factor to the hypoferraemia and anaemia of rheumatoid arthritis (Muirden and Senator, 1968;Mowat and Hothersall, 1968). The delay in the release of Fe59 injected in the form of labelled red cells from the inflamed rabbit joint supports this suggestion.…”

“…There is some evidence that this may be due to reduced availability of iron from storage sites in the reticulo-endothelial system (Weinstein, 1959;Owen and Lawson, 1966). Extensive deposits of iron are frequently found in the synovial membrane in this disease and these have recently been considered as a further important storage site for iron (Muirden and Senator, 1968;Mowat and Hothersall, 1968). Sequestration of iron in the synovium could contribute to the hypoferraemia and anaemia of this condition.…”

Nature of anaemia in rheumatoid arthritis. XI. Changes in iron metabolism induced by the administration of corticotrophin.

“…Several previous reports in this series have described abnormalities in the metabolism of iron in this disease (Roy, Alexander, and Duthie, 1955;Richmond, Gardner, Roy, and Duthie, 1956;Richmond, Roy, Gardner, Alexander, and Duthie, 1958;Gardner and Roy, 1961;Owen and Lawson, 1966;Lawson, Owen, and Mowat, 1967), and the present state of knowledge has been reviewed by Mowat and Hothersall (1968). The plasma iron is low in the presence of active disease (Bruzzone and Massimello, 1940;Nilsson, 1948), and the level is well correlated to the activity of the disease (Engstedt and Strandberg, 1966).…”

“…It was considered that these results provided evidence of increased iron storage in these patients. Mowat and Hothersall (1968) and Senator and Muirden (1968) have shown considerably higher concentrations of iron in the synovial tissue of patients with rheumatoid arthritis compared with controls. Since there is proliferation of synovial tissue in patients with rheumatoid arthritis, it follows that relatively large quantities of iron must be deposited in this tissue.…”

Intraarticular ferritin‐bound iron in rheumatoid arthritis: A factor that increases oxygen free radical‐induced tissue destruction

“…In rheumatoid arthritis (RA) the iron concentration'is increased in the synovial fluid and synovial membrane (1). Arthritis develops as a result of iron accumulation in the joint in hemochromatosis, which is characterized by a systemic overload of iron, and in hemophilia, in which synovial iron deposition results from recurrent hemorrhages.…”