Nature of cardiovascular decompensation during hemorrhagic hypotension

Nk, Hollenberg; Waters,; Toews,; Rr, Davies; Nickerson, Mark

doi:10.1152/ajplegacy.1970.219.5.1476

Cited by 9 publications

(6 citation statements)

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“…3 and 5). This finding, which agrees with the results of others (22,25,33,51) Therefore, the arterial hematocrit is determined by the cell volume, the plasma volume, and the Fcells factor, which reflects the distribution of cells between large and minute vessels. Among these three parameters the plasma volume generally showed the greatest change after hemorrhage (Fig.…”

Section: Blood Volumesupporting

confidence: 93%

“…3), the data suggest a progressive sequestration or loss of cells and plasma following retransfusion in these animals. This is in agreement with the suggestion of Hollenberg et al (33). Microcirculatory studies have shown a reduction in red cell deformability (6) and a stagnation in the microvasculature (1,35) in hemorrhagic shock.…”

Section: Blood Volumesupporting

confidence: 92%

“…The present study indicates that the transcapillary loss of protein-poor fluid in oligemia can be prevented by the removal of the spleen. Hollenberg et al (33) have shown that this fluid loss in the normal dogs can be reduced by the use of phenoxybenzamine (POB), an a-adrenergic blocking agent. Since POB blocks the splenic contraction after hemorrhage (33), the protective effect of POB against transcapillary fluid loss may be partially attributable to this functional splenectomy, in addition to the reduction of postcapillaryto-precapillary resistance ratio elsewhere.…”

Section: Role Of Spleenmentioning

confidence: 99%

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Blood volume, hemodynamic, and metabolic changes in hemorrhagic shock in normal and splenectomized dogs

Chien¹,

Dellenback²,

Usami³

et al. 1973

American Journal of Physiology-Legacy Content

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Section: Blood Volumesupporting

confidence: 93%

Section: Blood Volumesupporting

confidence: 92%

Section: Role Of Spleenmentioning

confidence: 99%

See 1 more Smart Citation

Blood volume, hemodynamic, and metabolic changes in hemorrhagic shock in normal and splenectomized dogs

Chien¹,

Dellenback²,

Usami³

et al. 1973

American Journal of Physiology-Legacy Content

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“…A complete time-course of renin during all phases of hemorrhagic shock, according to our knowledge, has not been reported. High (37) found that continuous infusion of norepinephrine into hemorrhagic dogs accelerated the rate of decompensation, measured as a more rapid reuptake of blood from the reservoir and earlier death. Pretreatment with the a-adrenergic blocker, phenoxybenzamine, delayed the onset and reduced the rate of reuptake of blood and prolonged survival.…”

Section: Methodsmentioning

confidence: 99%

Profile of Circulating Vasoactive Substances in Hemorrhagic Shock and Their Pharmacologic Manipulation

Jakschik¹,

Marshall²,

Kourik³

et al. 1974

J. Clin. Invest.

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A B S T R A C T (a)Hemorrhage(b) Plasma catecholamines (CA) steadily increased during hemorrhage and peaked during compensation (a 100-fold increase). The CA decreased progressively during decompensation.(c) Prostaglandin (PG) E-like material was observed in arterial blood for 15-60 min (after hemorrhage); the peak arterial concentration was 2.6 ng/ml blood. Indomethacin (i.v., before 80% of maximum bleedout): (i) confirmed the presence of PGE, (ii) increased blood pressure, and (iii) increased blood loss.(d) Thus: peripheral resistance during hemorrhagic shock seems temporally correlated with blood CA levels (and not PRA), and the renin-AII system contributes to the maintenance of vascular resistance and may markedly decrease perfusion of organs, such as kidney; the administration of the proper combination of specific antagonists of vasoconstrictor humoral substances may radically improve organ perfusion and could contribute to ultimate recovery from hemorrhagic shock.Preliminary results of this study were presented at the

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“…Loss of fluid from the circulation occurs after many forms of injury and is compensated for by the movement of fluid into the circulation from extravascular fluid compartments in uninjured tissues (Tabor, Rosenthal & Millican, 1951;Oberg, 1964; Mott, 1965; Hollenberg, Waters, Toews, Davies & Nickerson, 1970;Marty & Zweifach, 1970, 1971Weidner, Grega & Haddy, 1971). The increased ability of the 0-to 1-day-old rabbit to withstand the loss of fluid from the circulation may be due to greater efficiency of this compensation.…”

Section: Introductionmentioning

confidence: 99%

The compensation of post‐traumatic oedema in the rabbit at different ages

Little¹

1974

The Journal of Physiology

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SUMMARY1. The compensation of fluid loss from the circulation after an LD50 period of bilateral hind-limb ischaemia in a thermoneutral environment has been studied in the rabbit from birth until young adulthood.2. The fluid loss from the circulation was calculated from the increase in the great vessel haematocrit value as the red cell volume and -ce11swere unchanged after limb ischaemia. This 'apparent' fluid loss was compared with the 'actual' fluid loss calculated from the increase in water content of the injured limbs.3. The 0-to 1-day-old rabbit was better able to restore fluid, and protein, to the circulation than the older animal and suffered a smaller percentage reduction in arterial blood pressure after an LD50 period of ischaemia.4. The better compensation of post-traumatic fluid loss during the first 48 hr of life may be explained by the high capillary filtration coefficient and the post-traumatic increase in plasma protein osmotic pressure found at that age.5. The more efficient restoration ofthe plasma volume by the 0-to 1-dayold rabbit may account for the increased ability to withstand posttraumatic fluid loss at that age.

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Nature of cardiovascular decompensation during hemorrhagic hypotension

Cited by 9 publications

References 0 publications

Blood volume, hemodynamic, and metabolic changes in hemorrhagic shock in normal and splenectomized dogs

Blood volume, hemodynamic, and metabolic changes in hemorrhagic shock in normal and splenectomized dogs

Profile of Circulating Vasoactive Substances in Hemorrhagic Shock and Their Pharmacologic Manipulation

The compensation of post‐traumatic oedema in the rabbit at different ages

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