Nature spermidine and spermine alkaloids: Occurrence and pharmacological effects

Polyamine-containing natural products: structure, bioactivity, and biosynthesis

“…It possesses only three moieties: a L-Phe, a L-Val, and a guanylspermidine (guanyl-Spd) in sequence. 58 JBIR-94 (27) and JBIR-125 (28), two phenolic polyamine conjugates in Actinobacteria, were isolated from Streptomyces sp. R56-07.…”

“…The complicated and variable structures of polyamine-containing NPs are associated with their distinct biological properties, such as antimicrobial, antiviral, antiprotozoal, anticancer, iron-chelating, nematicidal, antiobesity and antiatherogenic activities. 3,4,20,[25][26][27][28] Some of the representative molecules have been used in the clinical treatment of malignant cancers and neurodegenerative diseases, for example, pingyangmycin, boanmycin, and squalamine (see Sections 2.1.3 and 2.1.4 for details). [29][30][31][32][33] In addition, a semisynthetic podophyllotoxin derivative F14512 in which a tail of polyamine Spm substitutes the glycosidic moiety of the chemotherapeutic etoposide (Fig.…”

Phenolic Compounds of Six Unexplored Asteraceae Species from Asia: Comparison of Wild and Cultivated Plants

“…The flavonoids identified in L. sibirica encompassed luteolin and its derivatives A compact chromatographic zone, characterized by closely spaced retention times, contained at least four compounds eluted in a low-polarity compound region. Their distinctive UV-absorption profile (λ max : 297 and 309 nm; Figure S1), molecular formulas (C 46 H 50 N 4 O 8 ), and mass-spectral patterns led to the identification of Ls-39-Ls-42 as isomeric phenolamines with a tetra-O-p-coumaroyl spermine basic structure [95] previously undescribed in Lactuca. The differences between these compounds are likely attributed to the number and location of cis and trans bonds in the structure of the p-coumaroyl fragments.…”