Nauclea orientalis (L.) Bark Extract Protects Rat Cardiomyocytes from Doxorubicin-Induced Oxidative Stress, Inflammation, Apoptosis, and DNA Fragmentation

Sandamali, Jayasinghe Arachchige Nirosha; Hewawasam, Ruwani Punyakanthi; Jayatilaka, Kamani Ayoma Perera Wijewardana; Mudduwa, Lakmini

doi:10.1155/2022/1714841

Cited by 11 publications

(3 citation statements)

References 48 publications

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“…Bark extract NT Bark extract protected the myocardium inflammation as a result of doxorubicin (Dox)-induced oxidative stress in Wistar rats [326]. Flowers extract suppressed TNF-α secretion in LPS-stimulated macrophages [327]; fruits extract-reduced carrageenin-induced paw oedema in rats [328]; also upregulated anti-inflammatory cytokines (IL-10 and 12), and downregulated pro-inflammatory cytokines (IL-6, IL-1β, TNF-α, and IFN-γ) [329]; rhizome extract reduced carrageenin-and serotonin-induced paw oedema in male albino Wistar rats [225]; leaves extract reduces the expression and productions of IL-1β, IL-6, TNF-α, PGE 2 , and NO; also reduced NF-κB activity by inhibiting NF-κB phosphorylation [330].…”

Section: Nauclea Orientalismentioning

confidence: 99%

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Yeshi

Turpin

Jamtsho³

et al. 2022

Molecules

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Australian tropical plants have been a rich source of food (bush food) and medicine to the first Australians (Aboriginal people), who are believed to have lived for more than 50,000 years. Plants such as spreading sneezeweed (Centipeda minima), goat’s foot (Ipomoea pes-caprae), and hop bush (Dodonaea viscosa and D. polyandra) are a few popular Aboriginal medicinal plants. Thus far, more than 900 medicinal plants have been recorded in the tropical region alone, and many of them are associated with diverse ethnomedicinal uses that belong to the traditional owners of Aboriginal people. In our effort to find anti-inflammatory lead compounds in collaboration with Aboriginal communities from their medicinal plants, we reviewed 78 medicinal plants used against various inflammation and inflammatory-related conditions by Aboriginal people. Out of those 78 species, we have included only 45 species whose crude extracts or isolated pure compounds showed anti-inflammatory properties. Upon investigating compounds isolated from 40 species (for five species, only crude extracts were studied), 83 compounds were associated with various anti-inflammatory properties. Alphitolic acid, Betulinic acid, Malabaric acid, and Hispidulin reduced proinflammatory cytokines and cyclooxygenase enzymes (COX-1 and 2) with IC50 values ranging from 11.5 to 46.9 uM. Other promising anti-inflammatory compounds are Brevilin A (from Centipeda minima), Eupalestin, and 5′-methoxy nobiletin (from Ageratum conyzoides), Calophyllolide (from Calophyllum inophyllum), and Brusatol (from Brucea javanica). D. polyandra is one example of an Aboriginal medicinal plant from which a novel anti-inflammatory benzoyl ester clerodane diterpenoid compound was obtained (compound name not disclosed), and it is in the development of topical medicines for inflammatory skin diseases. Medicinal plants in the tropics and those associated with indigenous knowledge of Aboriginal people could be a potential alternative source of novel anti-inflammatory therapeutics.

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Section: Nauclea Orientalismentioning

confidence: 99%

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Yeshi

Turpin

Jamtsho³

et al. 2022

Molecules

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“…This may indicate that the plant extracts from this species have the potential to protect cardiomyocytes from the damage caused by DOX. Many studies indicate that plant extracts, in general, may be promising agents for the alleviation of the side effects of DOX use associated with cardiomyocyte damage [ 34 , 35 , 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective Effect of Centaurea castriferrei Borbás & Waisb Extract against Doxorubicin-Induced Cardiotoxicity in H9c2 Cells

et al. 2023

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Doxorubicin (DOX) is one of the most used chemotherapeutic agents in the treatment of various types of cancer. However, a continual problem that is associated with its application in therapeutic regimens is the development of dose-dependent cardiotoxicity. The progression of this process is associated with a range of different mechanisms, but especially with the high level of oxidative stress. The aim of the study was to evaluate the effects of the water and methanol–water extracts from the plant Centaurea castriferrei (CAS) obtained by the ultrasound-assisted extraction method on the DOX-induced cardiotoxicity in the rat embryonic cardiomyocyte cell line H9c2. The H9c2 cells were treated for 48 h with the DOX and water or methanol–water extracts, or a combination (DOX + CAS H2O/CAS MeOH). The MTT assay, cell cycle analysis, and apoptosis detection revealed that both the tested extracts significantly abolished the cytotoxic effect caused by DOX. Moreover, the detection of oxidative stress by the CellROX reagent, the evaluation of the number of AP sites, and the expressions of the genes related to the oxidative stress defense showed substantial reductions in the oxidative stress levels in the H9c2 cells treated with the combination of DOX and CAS H2O/CAS MeOH compared with the DOX administered alone. The tested extracts did not affect the cytotoxic effect of DOX on the MCF-7 breast cancer cell line. The obtained results constitute the basis for further research in the context of the application of C. castriferrei extracts as adjuvants in the therapy regiments of cancer patients treated with DOX.

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“…Apart from land rehabilitation, N. orientalis also has the potential to be developed in plantation forest development because it is a fast-growing species. N. orientalis can be used as carpentry wood, pulp and paper raw material, furniture industry, flooring, molding, packaging boxes, sculpture, carving [10] and has the potential as an ingredient for medicines, such as antimalarials IOP Publishing doi:10.1088/1755-1315/1315/1/012070 2 [11], antibacterial [12], and inflammation [13].…”

Section: Introductionmentioning

confidence: 99%

Variation in seed morpho-physiological traits of Nauclea orientalis L. in a seedling seed orchard and the effect of seed sortation on their physiological parameters

Danu,

Rustam,

Cahyono

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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The aim of this study was to identify the morpho-physiological diversity of seeds in several mother trees of N. orientalis at 6-year-old in a seedling seed orchard in Parungpanjang, Bogor and to identify the effectiveness of seed sortation in improving the seed germination. A total of 17 mother trees were collected for their fruit, measured the morphology of the seeds and tested their germination. The results showed that fruit and seed dimensions and weight, germination capacity were strongly influenced by the mother tree. Germination capacity and the highest germination capacity was resulted by family no. 22-BT (90%) and 48-MJ (92%). The highest coefficient of variation was given by seed weight per fruit (83.03), followed by germination capacity (66.66) and fruit weight (65.95). Seed sortation had a significant effect on germination capacity, germination rate, and mean germination time, but had no significant effect on germination value. In general, a sieve size of 300-420 μm gave the best results for increasing germination capacity (59.5%), germination rate (1.67% day-1), and mean germination time (18 days). Other sieve sizes, i.e., 420-600 μm was also able to improve seed germination so that for seed sortation applications 300-600 μm sieve sizes can be used.

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Nauclea orientalis (L.) Bark Extract Protects Rat Cardiomyocytes from Doxorubicin-Induced Oxidative Stress, Inflammation, Apoptosis, and DNA Fragmentation

Cited by 11 publications

References 48 publications

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Cardioprotective Effect of Centaurea castriferrei Borbás & Waisb Extract against Doxorubicin-Induced Cardiotoxicity in H9c2 Cells

Variation in seed morpho-physiological traits of Nauclea orientalis L. in a seedling seed orchard and the effect of seed sortation on their physiological parameters

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