Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats

Ahmed, Osama M.; Hassan, Mohamed A.; Abdel-Twab, Sanaa M; Azeem, Manal N. Abdel

doi:10.1016/j.biopha.2017.07.094

Cited by 122 publications

(102 citation statements)

References 46 publications

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“…Oxidative stress is another key feature of GDM, and is characterized by differential antioxidant expression and increases in reactive oxygen species . Animal models of diabetes have shown that naringenin improves SOD, catalase, glutathione peroxidase, and GR activity in the liver, kidney, and brain . Similarly, in this study, in vitro, naringenin treatment significantly upregulated catalase mRNA expression in placenta and SOD1, catalase and GR mRNA expression in VAT.…”

Section: Discussionsupporting

confidence: 68%

“…One novel polyphenol is naringenin, which exists in grapefruit and citrus fruits, and has been found to possess potent anti‐diabetic, anti‐inflammatory, and anti‐oxidative properties . Naringenin has been shown to improve blood glucose and serum insulin levels in streptozotocin‐induced and high‐fat‐diet‐induced rodent models of type 2 diabetes .…”

Section: Introductionmentioning

confidence: 99%

“…Research also suggests that naringenin reduces expression of pro‐inflammatory cytokines and chemokines in vitro and in vivo . Improved antioxidant protein expression and activity with naringenin treatment has also been identified in animal models of diabetes . Mechanistically, naringenin has been shown to elicit these effects via inhibition of key signaling pathways, such as nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB), Akt, and mitogen‐activated protein kinases (MAPK) …”

Section: Introductionmentioning

confidence: 99%

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Anti‐Diabetic, Anti‐Inflammatory, and Anti‐Oxidant Effects of Naringenin in an In Vitro Human Model and an In Vivo Murine Model of Gestational Diabetes Mellitus

Nguyen-Ngo

Willcox

Lappas

2019

Molecular Nutrition Food Res

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Scope Gestational diabetes mellitus (GDM), which affects up to 20% of pregnant women, is associated with maternal peripheral insulin resistance, low‐grade inflammation, and oxidative stress. The flavonoid naringenin has potent anti‐diabetic, anti‐inflammatory, and anti‐oxidative properties; however, its effects in GDM remain unknown. The study aimed to determine the effects of naringenin on glucose metabolism, inflammation, and oxidative stress associated with GDM both in vitro and in vivo. Methods and results In vitro, human tissue samples obtained at term elective Caesarean section are stimulated with tumour necrosis factor alpha (TNF) to develop a GDM‐like environment. Naringenin treatment significantly improves TNF‐impaired glucose uptake in skeletal muscle. In placenta and visceral adipose tissue (VAT), naringenin significantly reduces expression of pro‐inflammatory cytokines and chemokines and increases antioxidant mRNA expression. Mechanistically, naringenin suppresses nuclear factor κB activation. In vivo, pregnant heterozygous db/+ mice are used to model GDM. Daily intraperitoneal injections of GDM mice with naringenin from gestational day 10–17 significantly improve glucose tolerance, reduces IL1A mRNA expression, and increases antioxidant mRNA expression in placenta, VAT, and subcutaneous adipose tissue. Conclusion Naringenin is shown to improve insulin sensitivity, inflammation, and oxidative stress associated with GDM and shows promise as a novel preventive therapeutic.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti‐Diabetic, Anti‐Inflammatory, and Anti‐Oxidant Effects of Naringenin in an In Vitro Human Model and an In Vivo Murine Model of Gestational Diabetes Mellitus

Nguyen-Ngo

Willcox

Lappas

2019

Molecular Nutrition Food Res

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“…injected with 55 mg of streptozotocin/kg body weight dissolved in citrate buffer (pH 4.5) after i.p. injection of 120 mg of nicotinamide/kg body weight dissolved in saline [13,14] level higher than 200 mg/dl after 48 h of streptozotocin/nicotinamide administration were considered as diabetic rats.…”

Section: Preparation Of Diabetic Ratsmentioning

confidence: 99%

Selenium decreases triglycerides and VLDL-c in diabetic rats exposed to electromagnetic radiation from mobile phone base stations

Ismaiil

Joumaa

Moustafa

2019

Journal of Taibah University for Science

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This study investigated the effects of exposure of diabetic rats to electromagnetic radiation (EMR) of 900 MHz from cell phone base stations antenna for four weeks on plasma triglycerides and cholesterol. We also examined whether selenium administration into these rats affects the levels of these parameters. Our results showed that the exposure of diabetic rats to this EMR increased the plasma triglycerides, total cholesterol and VLDL-c. The daily intraperitoneally injection of 2.0 μg selenium/kg body weight as sodium selenite into these rats decreased the triglycerides and VLDL-c levels compared to diabetic rats with EMR exposure. Selenium also restored the normal levels of plasma triglycerides, total cholesterol and HDL-c as compared to control rats. In conclusion, selenium decreased the elevated levels of triglycerides and cholesterol in diabetic rats exposed to EMR from cell phone base stations and hence it may decrease the development of some diabetic complications.

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“…Previous in vitro and in vivo studies show naringin has antidiabetic activity, and almost all studies attribute that effect to its antioxidant property and its ability to counter oxidative stress [Meier et al, 2008;Pari and Suman, 2010;Liu et al, 2016;Nzuza et al, 2016;Ahmed et al, 2017;Lim et al, 2018]. Most of the studies show that naringin has a beneficial effect on diabetes through extrapancreatic mechanisms like reduced glucose absorption [Reshmi et al, 2017;Taslimi et al, 2017], regulation of hepatic enzyme dysfunction [Punithavathi et al, 2008;Sharma et al, 2011;Pu et al, 2012;Ahmed et al, 2017;Pari and Chandramohan, 2017] and improvement in peripheral resistance [Priscilla et al, 2015;Ahmed et al, 2017]. Available literature shows that naringin could increase insulin levels [Pari and Suman, 2010;Sharma et al, 2011;Ahmed et al, 2012;Pu et al, 2012;Priscilla et al, 2015;Lim et al, 2018] in diabetic animals, but the mechanism proposed for such an activity was rather a general antioxidative, anti-inflammatory, and antiapoptotic function.…”

Section: Introductionmentioning

confidence: 99%

Naringin (4′,5,7-Trihydroxyflavanone 7-Rhamnoglucoside) Attenuates β-Cell Dysfunction in Diabetic Rats through Upregulation of PDX-1

Subramanian

Balaji

Sekaran

et al. 2018

Cells Tissues Organs

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Background: Pancreatic duodenal homeobox-1 (PDX-1) is a key transcription factor which regulates Insulin gene expression and insulin secretion in adult β-cells and helps to maintain β-cells mass. Naringin, a flavanone, owing to its antioxidant property, is reported to have antidiabetic effects. Objectives: The present study tries to evaluate the role of naringin on the β-cell-specific transcription factor PDX-1 in diabetic rats. Methods: Diabetes was induced in male rats using streptozotocin and treated with naringin (100 mg/kg) orally for 4 and 8 weeks. Serum insulin level, Pdx-1 and Insulin gene expression, and PDX-1 protein expression were assessed in the rat pancreas. Histopathological and ultrastructural changes in the islet and β-cells were observed. Results: Naringin prevented leukocytic infiltration in the pancreas of diabetic rats and recouped the β-cells with adequate secretory granules. Naringin-treated diabetic rats showed significantly increased mRNA expression of Pdx-1 and Insulin genes, increased expression of transcription factor PDX-1, and higher serum insulin levels than the diabetic control animals. These changes were more pronounced in the 8-week naringin-treated diabetic animals. Conclusions: Naringin was found to be an effective antidiabetic agent which increased Insulin gene expression and insulin secretion by upregulating the PDX-1 gene and protein expression.

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Navel orange peel hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats

Cited by 122 publications

References 46 publications

Anti‐Diabetic, Anti‐Inflammatory, and Anti‐Oxidant Effects of Naringenin in an In Vitro Human Model and an In Vivo Murine Model of Gestational Diabetes Mellitus

Anti‐Diabetic, Anti‐Inflammatory, and Anti‐Oxidant Effects of Naringenin in an In Vitro Human Model and an In Vivo Murine Model of Gestational Diabetes Mellitus

Selenium decreases triglycerides and VLDL-c in diabetic rats exposed to electromagnetic radiation from mobile phone base stations

Naringin (4′,5,7-Trihydroxyflavanone 7-Rhamnoglucoside) Attenuates β-Cell Dysfunction in Diabetic Rats through Upregulation of PDX-1

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