Introduction
This study investigates factors associated with recurrent rhegmatogenous retinal detachment (RRD), macular complications, and visual outcomes after pars plana vitrectomy (PPV) without perfluorocarbon liquids (PFCLs) for primary RRD.
Methods
A longitudinal cohort study included consecutive patients with RRD who underwent PFCL-free PPV. Postoperative visual acuity and spectral-domain optical coherence tomography findings [cystoid macular edema (CME), epiretinal membrane (ERM), ellipsoid zone/interdigitation zone (EZ/IZ) damage] were collected. Logistic regression and linear mixed models analyzed rates and risk factors for RRD recurrence, CME, ERM, EZ/IZ damage, and visual acuity at 12 months.
Results
346 eyes with RRD were studied. Single-operation success rates were 96% and 93% for uncomplicated (
n
= 274 eyes) and complicated (
n
= 72 eyes) RRD, respectively. Factors associated with RRD recurrence were posterior retinal breaks [odds ratio (OR) = 10.7 compared to peripheral retinal breaks,
p
= 0.008], silicone oil tamponade (OR = 5.66 compared to gas,
p
= 0.01), and sectorial laser retinopexy (OR = 4.34 compared to 360° laser retinopexy,
p
= 0.007). The prevalence of CME, ERM, and EZ/IZ damage at 12 months was 10%, 9%, and 6%, respectively. Eyes with EZ/IZ defects had worse postoperative visual acuity in both uncomplicated and complicated RRD. Proliferative vitreoretinopathy (OR = 2.95,
p
= 0.03) and silicone oil tamponade (OR = 3.70 compared to gas,
p
= 0.05) were associated with EZ/IZ damage.
Conclusions
PFCL-free PPV demonstrated satisfactory single-operation success rates for uncomplicated and complicated RRD, with a low prevalence of macular complications. Analyzing factors associated with RRD recurrence can provide provisional recommendations for PFCL-free approaches in the absence of randomized trials.
Supplementary Information
The online version contains supplementary material available at 10.1007/s40123-023-00811-z.