Navigating chemical reaction space – application to DNA-encoded chemistry

Chines, Silvia; Ehrt, Christiane; Potowski, Marco; Biesenkamp, Felix; Grützbach, Lars; Brunner, Michael; Broek, Frederik van den; Bali, Shilpa; Ickstadt, Katja; Brunschweiger, Andreas

doi:10.1039/d2sc02474h

Cited by 3 publications

(2 citation statements)

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“…Altogether, a photochemical DEL reaction was performed in the photoreactor developed by rapid prototyping and adapted to the flow reactor setup. These promising results pave the way to a wider application and scalability for continuous flow systems and fast access to a new chemical reaction space in DELT ( González-Esguevillas et al, 2021 ; Chines et al, 2022 ). The photoredox reactions exhibit enormous potential for synthesizing DEL.…”

Section: Discussionmentioning

confidence: 94%

Development of a microfluidic photochemical flow reactor concept by rapid prototyping

Dinter,

Willems,

Nissalk

et al. 2023

Front. Chem.

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The transfer from batch to flow chemistry is often based on commercial microfluidic equipment, such as costly complete reactor systems, which cannot be easily tailored to specific requirements of technologies such as DNA-encoded library technology (DELT), in particular for increasingly important photochemical reactions. Customized photoreactor concepts using rapid prototyping technology offer a modular, flexible, and affordable design that allows for adaptation to various applications. In order to validate the prototype reactors, a photochemical pinacol coupling reaction at 368 nm was conducted to demonstrate the transfer from batch to flow chemistry. The conversion rates were optimized by adapting the design parameters of the microfluidic flow photoreactor module. Subsequently, the photoreactor module has been extended to an application with DNA-tagged substrates by switching to LEDs with a wavelength of 454 nm. The successful recovery of DNA confirmed the feasibility of the modular-designed flow photo reactor. This collaborative approach holds enormous potential to drive the development of DELT and flow equipment design.

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Section: Discussionmentioning

confidence: 94%

Development of a microfluidic photochemical flow reactor concept by rapid prototyping

Dinter,

Willems,

Nissalk

et al. 2023

Front. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

“…After tagged barcode amplification and sequencing, the optimal binder can be thus identified in the selection of DELs. [20][21][22][23][24][25] Generally, the encoded libraries are constructed via iterative steps of combinatory synthesis and enzymatic encoding ligation. [26][27][28][29][30] Numerous reaction toolkits, which must be DNA-compatible, have been thereby developed and employed to construct encoded libraries, and the building blocks (BBs) for library construction should be conveniently accessible or commercially available to expand the chemical diversities to more complicated molecular architectures beyond encoding early-stage peptide-like libraries.…”

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confidence: 99%