Navigating secondary breast angiosarcoma: a case report

Abstract

BACKGROUND AND PURPOSE: Secondary breast angiosarcoma is a rare and aggressive malignancy that poses significant diagnostic and therapeutic challenges. Arising either from metastasis or as a complication of previous radiation therapy, it presents distinct clinical characteristics and prognostic implications compared to primary breast angiosarcoma. Understanding the unique features of secondary breast angiosarcoma is essential for guiding clinical decision-making and optimizing patient outcomes in the management of this challenging malignancy. METHODS: Imaging modalities such as mammography, ultrasound, or MRI may be used to evaluate the extent of the tumor, assess lymph node involvement, and detect distant metastases. A tissue biopsy is essential for confirming the diagnosis of angiosarcoma. Histopathological examination of the biopsy specimen helps to differentiate angiosarcoma from another breast tumor and determine the tumor grade. RESULTS: As angiosarcoma is relatively rare, there is a lack of detailed information regarding its progression. However, when compared to more common types of breast cancer, angiosarcoma of the breast generally carries a worse outlook. This is largely attributed to its tendency to be diagnosed later and its higher likelihood of rapid spread to distant sites within the body. CONCLUSIONS: Breast secondary angiosarcoma is associated with poor prognosis, often due to its aggressive nature and limited treatment options. Close monitoring, aggressive treatment strategies, and supportive care are essential in managing this challenging malignancy.