Navigating the paraneoplastic neurological syndromes

Giannopoulou, Chariklia

doi:10.1007/s00259-002-1005-0

Cited by 10 publications

(2 citation statements)

References 25 publications

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“…It has been reported that FDG PET/CT is a highly accurate diagnostic modality for detecting underling primary tumor in PNS-suspected patients. [ 7 , 9 , 10 ] Although our patient had typical clinical features and a positive anti-Yo antibody, no malignancy was found after comprehensive medical evaluation. Therefore, whole-body dual-modality PET/CT was performed, which revealed intense metabolic activity in the cerebellum associated with diffused hypometabolism in the rest of the brain (Fig.…”

Section: Discussionmentioning

confidence: 80%

“…Early identification and localization of the primary malignancy is essential for an early resection before the occurrence of metastases. [ 7 ] Positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) is crucial in the early detection of the unknown primary tumors. [ 8 ] Most of the recently published studies had reported that positron emission tomography–computed tomography (PET/CT) has significantly high sensitivity and specificity for detecting primary malignancies, thereby high accuracy in confirming the diagnosis of PCD.…”

Section: Introductionmentioning

confidence: 99%

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Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism

Abdulaziz

Zhang

et al. 2018

Medicine

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Rationale:Paraneoplastic cerebellar degeneration (PCD) is an immune-mediated neurological deficit affecting the cerebellum. Anti-Yo antibody positive PCD is a rare occurrence most likely associated with gynecologic or breast malignancies. The identification of the underlying tumor is a diagnostic challenge in many of these patients.Patient concerns:We present a 68-year-old woman with acute symptoms of PCD as a first sign of underlying occult malignancy. Further investigation revealed a positive anti-Yo antibody. Although brain magnetic resonance imaging (MRI) was unremarkable, positron emission tomography (PET)/computed tomography (CT) revealed intense hypermetabolism of cerebellum and diffused hypometabolism in the rest of brain. On 1-year follow-up, despite the primary malignancy is still unknown, her symptoms improved significantly after immunotherapy.Diagnoses:Paraneoplastic cerebellar degeneration.Interventions:The patient was given IV methylprednisolone 500 mg once a day for 5 consecutive days, followed by oral prednisone 60 mg once a day for 3 months.Outcomes:The patient's symptoms were gradually improved during the hospitalization period. On one year follow up, she was able to walk independently and perform some simple tasks.Lessons:Cerebellar hypermetabolism in PCD suspected patients may help confirming the diagnosis in an earlier stage and may predict a better outcome after immunotherapy.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism

Abdulaziz

Zhang

et al. 2018

Medicine

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Cerebellar degeneration and ocular myasthenia gravis in a patient with recurring ovarian carcinoma

et al. 2009

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Myasthenia gravis (MG) and paraneoplastic cerebellar degeneration (PCD) are immune-mediated syndromes that can represent paraneoplastic disorders. We report a patient with history of ovarian carcinoma that presented with ptosis, diplopia and gait ataxia. Neurophysiological examination and laboratory tests revealed the presence of MG and PCD. An integrated FDG-PET/contrast-enhanced CT scan showed tumor recurrence. This is to the best of our knowledge the first association of MG and PCD with recurring ovarian carcinoma.

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Treatment of anti-Ma2/Ta paraneoplastic syndrome

Kraker

2008

Curr Treat Options Neurol

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Navigating the paraneoplastic neurological syndromes

Cited by 10 publications

References 25 publications

Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism

Paraneoplastic cerebellar degeneration associated with cerebellar hypermetabolism

Cerebellar degeneration and ocular myasthenia gravis in a patient with recurring ovarian carcinoma

Treatment of anti-Ma2/Ta paraneoplastic syndrome

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