Navigating the Social Environment in Adolescence: The Role of Social Brain Development

Andrews, Jack L; Ahmed, Saz; Blakemore, Sarah‐Jayne

doi:10.1016/j.biopsych.2020.09.012

Cited by 197 publications

(117 citation statements)

References 139 publications

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“…Still, it has been shown that chronic stress exposure during this sensitive developmental period can lead to alterations in the HPA axis ( Lupien et al, 2009 ; Schmidt et al, 2010 ; Uno et al, 1989 ) and the noradrenergic system ( Joëls and Baram, 2009 ; Saavedra-Rodríguez and Feig, 2013 ; Schmidt et al, 2008 ; Yohn et al, 2019 ). Additionally, chronic stress exposure during adolescence can lead to enduring phenotypes that are different to those observed when stress exposure occurs during adulthood ( Andrews et al, 2021 ; Somerville et al, 2010 ). This is no surprise given the substantial reorganisation and the developmental processes occurring throughout the brain and HPA axis during this phase ( Casey et al, 2008 ; Schmidt et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

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Chronic adolescent stress increases exploratory behavior but does not appear to change the acute stress response in adult male C57BL/6 mice

Sturman

Ziegler

Privitera

et al. 2021

Neurobiology of Stress

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Chronic stress exposure in adolescence can lead to a lasting change in stress responsiveness later in life and is associated with increased mental health issues in adulthood. Here we investigate whether the Chronic Social Instability (CSI) paradigm influences the behavioral and molecular responses to novel acute stressors in mice, and whether it alters physiological responses influenced by the noradrenergic system. Using large cohorts of mice, we show that CSI mice display a persistent increase in exploratory behaviors in the open field test alongside small but widespread transcriptional changes in the ventral hippocampus. However, both the transcriptomic and behavioral responses to novel acute stressors are indistinguishable between groups. In addition, the pupillometric response to a tail shock, known to be mediated by the noradrenergic system, remains unaltered in CSI mice. Ultra-high performance liquid chromatography analysis of monoaminergic neurotransmitter levels in the ventral hippocampus also shows no differences between control or CSI mice at baseline or in response to acute stress. We conclude that CSI exposure during adolescence leads to persistent changes in exploratory behavior and gene expression in the hippocampus, but it does not alter the response to acute stress in adulthood and is unlikely to alter the function of the noradrenergic system.

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Section: Introductionmentioning

confidence: 99%

“…Adolescence is a period during which social environmental cues are particularly important ( Andrews et al, 2021 ; Casey et al, 2008 ; Somerville et al, 2010 ). The chronic social instability (CSI) paradigm was created in order to investigate the effects of chronic stress exposure during adolescence ( Schmidt et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Chronic adolescent stress increases exploratory behavior but does not appear to change the acute stress response in adult male C57BL/6 mice

Sturman

Ziegler

Privitera

et al. 2021

Neurobiology of Stress

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“…Globally, depression and anxiety are leading causes of disability among young people (Whiteford et al, 2013). These disorders typically first emerge during adolescence, a period of marked psychological, biological and social change (Andrews et al, 2021;Kessler et al, 2007;Merikangas et al, 2010). It is estimated that by mid adolescence lifetime trajectories of mental ill health are established, and the subsequent social and economic costs associated with depression and anxiety are large (Hu, 2006;Patton et al, 2014;Whiteford et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Evaluating the effectiveness of a universal eHealth school-based prevention program for depression and anxiety, and the moderating role of friendship network characteristics

Andrews¹,

Birrell²,

Chapman³

et al. 2021

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Background. Lifetime trajectories of mental ill health are often established during adolescence. Effective interventions to prevent the emergence of mental health problems are needed. In the current study we assessed the efficacy of the CBT informed Climate Schools universal eHealth preventive mental health program, relative to a control. We also explored whether the intervention had differential effects on students with varying degrees of social connectedness. Method. We evaluated the efficacy of the Climate Schools mental health program (19 participating schools; average age at baseline was 13.6) versus an active control group (18 participating schools; average age at baseline was 13.5) which formed part of a large cluster randomised controlled trial in Australian schools. Measures of internalising problems, depression and anxiety were collected at baseline, immediately following the intervention and at 6-, 12- and 18-months post intervention. Immediately following the intervention, 2539 students provided data on at least one outcome of interest (2065 students at 18 months post intervention). Results. We found no evidence that the stand-alone mental health intervention improved outcomes, on any measure, relative to a control. Across all participants we observed small, but significant, increases in internalising problems, depression, and anxiety at 18 months post intervention, relative to baseline. Student’s social connectedness did not influence intervention outcomes. Conclusion. These results are consistent with recent findings that universal school-based, CBT informed, preventive interventions for mental health have limited efficacy when delivered alone. We highlight the potential for combined intervention approaches, and more targeted interventions, to better improve outcomes.

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“…Still, it has been shown that chronic stress exposure during this sensitive developmental period can lead to alterations in the HPA axis [8,18,19] and the noradrenergic system [20][21][22][23]. Additionally, chronic stress exposure during adolescence can lead to enduring phenotypes that are different to those observed when stress exposure occurs during adulthood [14,15]. This is no surprise given the substantial reorganisation and the developmental processes occurring throughout the brain and HPA axis during this phase [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…Adolescence is a period during which social environmental cues are particularly important [14][15][16]. The chronic social instability (CSI) paradigm [17] was created in order to investigate the effects of chronic stress exposure during adolescence.…”

Section: Introductionmentioning

confidence: 99%

Chronic adolescent stress increases exploratory behavior but does not change the acute stress response in adult male C57BL/6 mice

Sturman

Ziegler

Privitera

et al. 2021

Preprint

View full text Add to dashboard Cite

Chronic stress exposure in adolescence can lead to a lasting change in stress responsiveness later in life and is associated with increased mental health issues in adulthood. Here we investigate whether the Chronic Social Instability (CSI) paradigm in mice influences the behavioural and molecular responses to novel acute stressors, and whether it alters physiological responses influenced by the noradrenergic system. Using large cohorts of mice, we show that CSI mice display a persistent increase in exploratory behaviors in the open field test alongside small but widespread transcriptional changes in the ventral hippocampus. However, both the transcriptomic and behavioural responses to novel acute stressors are indistinguishable between groups. In addition, the pupillometric response to a tail shock, known to be mediated by the noradrenergic system, remains unaltered in CSI mice. Ultra-high performance liquid chromatography analysis of monoaminergic neurotransmitter levels in the ventral hippocampus also shows no differences between control or CSI mice at baseline or in response to acute stress. We conclude that CSI exposure during adolescence leads to persistent changes in exploratory behavior and gene expression in the hippocampus, but it does not alter the response to acute stress challenges in adulthood and is unlikely to alter the function of the noradrenergic system.

show abstract

Navigating the Social Environment in Adolescence: The Role of Social Brain Development

Cited by 197 publications

References 139 publications

Chronic adolescent stress increases exploratory behavior but does not appear to change the acute stress response in adult male C57BL/6 mice

Chronic adolescent stress increases exploratory behavior but does not appear to change the acute stress response in adult male C57BL/6 mice

Evaluating the effectiveness of a universal eHealth school-based prevention program for depression and anxiety, and the moderating role of friendship network characteristics

Chronic adolescent stress increases exploratory behavior but does not change the acute stress response in adult male C57BL/6 mice

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