Navigating through chemical space and evolutionary time across the Australian continent in plant genus <i>Eremophila</i>

Gericke, Oliver; Fowler, Rachael M.; Heskes, Allison M.; Bayly, Michael J.; Semple, Susan J.; Ndi, Chi P.; Løland, Claus J.; Murphy, Daniel J.; Buirchell, Bevan; Møller, Birger Lindberg

doi:10.1111/tpj.15448

Cited by 15 publications

(21 citation statements)

References 114 publications

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“…A subset of 291 specimens representing 80% of the species in the tribe was included in the chemo‐evolutionary analysis. Phylogenetic analyses of these data identified eight well‐supported major lineages (Figure 3) (Gericke et al., 2021). The study highlighted a complicated evolution of Eremophila , including polyploidy and introgression between species.…”

Section: Resultsmentioning

confidence: 99%

“…For all experimental details, see Gericke et al. (2021). [Colour figure can be viewed at wileyonlinelibrary.com]…”

Section: Resultsmentioning

confidence: 99%

“…Eremophila is the largest genus within the plant tribe Myoporeae (Fowler et al, 2020(Fowler et al, , 2021. The aim of our study was to obtain new knowledge on the bioactivities of the natural products present across the entire genus of Eremophila using DNA sequencing and extensive chemical profiling (Gericke et al, 2021). The summarized results presented here were obtained by a highly multidisciplinary crosscontinental team, with research groups located in Adelaide, Perth, Melbourne and Copenhagen.…”

Section: Natural Sciencementioning

confidence: 99%

“…Herein, TMC A contains a diverse range of metabolites, whereas TMC B is rich in metabolites from the serrulatane and viscidane diterpenoid class. For all experimental details, see Gericke et al (2021).…”

Section: Natural Sciencementioning

confidence: 99%

“…The validity of the predicted structures assigned to subnetworks was greatly improved by including numerous reference compounds isolated from Eremophila species in the analyses. Among the reference compounds were a large number of flavonoids as well as sesquiterpenoids and diterpenoids, each of which was anchored within a specific network (Gericke et al, 2020(Gericke et al, , 2021. The results of these subnetwork analyses can in future be used to predict the type of enzymes involved in the respective chemical conversions and thereby guide the elucidation of the biosynthetic routes to chemicals of interest (Figures 4-6) (Gericke et al, 2021).…”

Section: Natural Sciencementioning

confidence: 99%

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Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

Semple

Buirchell²,

Fowler

et al. 2022

The Plant Journal

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SUMMARY In a cross‐continental research initiative, including researchers working in Australia and Denmark, and based on joint external funding by a 3‐year grant from the Novo Nordisk Foundation, we have used DNA sequencing, extensive chemical profiling and molecular networking analyses across the entire Eremophila genus to provide new knowledge on the presence of natural products and their bioactivities using polypharmocological screens. Sesquiterpenoids, diterpenoids and dimers of branched‐chain fatty acids with previously unknown chemical structures were identified. The collection of plant material from the Eremophila genus was carried out according to a ‘bioprospecting agreement’ with the Government of Western Australia. We recognize that several Eremophila species hold immense cultural significance to Australia's First Peoples. In spite of our best intentions to ensure that new knowledge gained about the genus Eremophila and any potential future benefits are shared in an equitable manner, in accordance with the Nagoya Protocol, we encounter serious dilemmas and potential conflicts in making benefit sharing with Australia's First Peoples a reality.

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Section: Resultsmentioning

confidence: 99%

“…For all experimental details, see Gericke et al. (2021). [Colour figure can be viewed at wileyonlinelibrary.com]…”

Section: Resultsmentioning

confidence: 99%

Section: Natural Sciencementioning

confidence: 99%

Section: Natural Sciencementioning

confidence: 99%

Section: Natural Sciencementioning

confidence: 99%

See 3 more Smart Citations

Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

Semple

Buirchell²,

Fowler

et al. 2022

The Plant Journal

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Deciphering Complex Natural Mixtures through Metabolome Mining of Mass Spectrometry Data

Hooft

Ernst

Papenberg

et al. 2023

Recent Advances in Polyphenol Research

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Pollination crisis Down‐Under: Has Australasia dodged the bullet?

Pyke,

Prendergast,

Ren

2023

Ecology and Evolution

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Since mid‐1990s, concerns have increased about a human‐induced “pollination crisis.” Threats have been identified to animals that act as plant pollinators, plants pollinated by these animals, and consequently human well‐being. Threatening processes include loss of natural habitat, climate change, pesticide use, pathogen spread, and introduced species. However, concern has mostly been during last 10–15 years and from Europe and North America, with Australasia, known as Down‐Under, receiving little attention. So perhaps Australasia has “dodged the bullet”? We systematically reviewed the published literature relating to the “pollination crisis” via Web of Science, focusing on issues amenable to this approach. Across these issues, we found a steep increase in publications over the last few decades and a major geographic bias towards Europe and North America, with relatively little attention in Australasia. While publications from Australasia are underrepresented, factors responsible elsewhere for causing the “pollination crisis” commonly occur in Australasia, so this lack of coverage probably reflects a lack of awareness rather than the absence of a problem. In other words, Australasia has not “dodged the bullet” and should take immediate action to address and mitigate its own “pollination crisis.” Sensible steps would include increased taxonomic work on suspected plant pollinators, protection for pollinator populations threatened with extinction, establishing long‐term monitoring of plant–pollinator relationships, incorporating pollination into sustainable agriculture, restricting the use of various pesticides, adopting an Integrated Pest and Pollinator Management approach, and developing partnerships with First Nations peoples for research, conservation and management of plants and their pollinators. Appropriate Government policy, funding and regulation could help.

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Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

Cited by 15 publications

References 114 publications

Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

Deciphering Complex Natural Mixtures through Metabolome Mining of Mass Spectrometry Data

Pollination crisis Down‐Under: Has Australasia dodged the bullet?

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