Navigating zinc-involved nanomedicine in oncotherapy

Yang, Fang; Yao, Junlie; Zhang, Aoran; Qiu, Yue; Li, Zihou; Wu, Xiaoyan; Li, Zhouhua; Wu, Aiguo

doi:10.1039/d2nr06857e

“…Besides small-molecule zinc ionophores, zinc-involved nanomedicines for cancer therapy have recently been reported to deliver exogenous Zn 2 + into tumor cells and induce cell death. [50] The pH-responsive zeolitic imidazolate framework-8 (ZIF-8), composed of 2-methylimidazole and Zn 2 + , can serve as an exogenous Zn 2 + source due to its excellent degradation ability. [51] However, the hydrophobicity and relatively large size of ZIF-8 confine its anti-tumor applications.…”

Section: Zinc Overloadmentioning

confidence: 99%

Modulation of Metal Homeostasis for Cancer Therapy

Yang,

Fan,

Guo

2024

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Metal ions such as iron, zinc, copper, manganese, and calcium are essential for normal cellular processes, including DNA synthesis, enzyme activity, cellular signaling, and oxidative stress regulation. When the balance of metal homeostasis is disrupted, it can lead to various pathological conditions, including cancer. Thus, understanding the role of metal homeostasis in cancer has led to the development of anti‐tumor strategies that specifically target the metal imbalance. Up to now, diverse small molecule‐based chelators, ionophores, metal complexes, and metal‐based nanomaterials have been developed to restore the normal balance of metals or exploit the dysregulation for therapeutic purposes. They hold great promise in inhibiting tumor growth, preventing metastasis, and enhancing the effectiveness of existing cancer therapies. In this review, we aim to provide a comprehensive summary of the strategies employed to modulate the homeostasis of iron, zinc, copper, manganese, and calcium for cancer therapy. Their modulation mechanisms for metal homeostasis are succinctly described, and their recent applications in the field of cancer therapy are discussed. At the end, the limitations of these approaches are addressed, and potential avenues for future developments are explored.

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“…ZBD is commonly used for immunological effects, which prevent disease infections in cancer treatments [83]. Its advantages are low toxicity generally, fewer side effects, and a lack of redox activity [84].…”

Section: Copper and Zinc For Anti-chemoresistance In Osteosarcoma The...mentioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi¹,

Miskon²

2023

Preprint

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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“…ZBD is commonly used for immunological effects, which prevent disease infections in cancer treatments [ 80 ]. Its advantages are low toxicity generally, fewer side effects, and a lack of redox activity [ 81 ].…”

Section: Copper and Zinc For Anti-chemoresistance In Osteosarcoma The...mentioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi

¹

,

Miskon

²

2023

Molecules

17

0

View full text Add to dashboard Cite

Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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Navigating zinc-involved nanomedicine in oncotherapy

Abstract: Zinc (Zn), extolled as “the flower of life” in modern medicine, has been extensively highlighted with its physiological functions to maintain the growth, development, and metabolism homeostasis. Driven by the...

Cited by 4 publications

References 106 publications

Modulation of Metal Homeostasis for Cancer Therapy

Modulation of Metal Homeostasis for Cancer Therapy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

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