Navigation using indocyanine green fluorescence imaging for hepatoblastoma pulmonary metastases surgery

Kitagawa, Norihiko; Sato, Masato; Mochizuki, Kiyofumi; Usui, Hidehito; Miyagi, Hisayuki; Nakamura, Kaori; Tanaka, Mio; Tanaka, Yukichi; Kusano, Mitsuo; Ohtsubo, Seiji

doi:10.1007/s00383-015-3679-y

Cited by 67 publications

(83 citation statements)

References 19 publications

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“…Patients 5 and 9, who underwent total resection of solitary pulmonary metastasis before PBSCT, were alive, with no evidence of recurrence, at the time of writing. ICG fluorescence imaging navigation was used to achieve complete removal of pulmonary metastases for patient 9, according to a previous report . Patient 6, who underwent autologous PBSCT with no detectable tumor, despite sustained elevation of serum AFP level, eventually DOD, which was subsequently detected in the omentum.…”

Section: Resultsmentioning

confidence: 99%

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Prognostic and therapeutic factors influencing the clinical outcome of hepatoblastoma after liver transplantation: A single‐institute experience

Umeda

Okajima

Kawaguchi

et al. 2018

Pediatric Transplantation

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LT has contributed to an elevation in cure rates for patients with unresectable HB; however, patients with recurrent HB after LT have poor prognosis. To analyze the prognostic and therapeutic factors that influence the clinical outcome of patients with HB receiving LT, we retrospectively analyzed 24 patients with HB who underwent LT between 1997 and 2015. The 5-year OS rate of all patients was 69.6±9.7%. The 5-year OS rate of 11 patients receiving salvage LT for recurrent tumor after a primary resection was comparable to that of 13 patients receiving primary LT. Among 12 evaluable patients receiving primary LT, six of 10 patients with a decline of serum AFP >95% at LT are currently alive and in remission, whereas two patients with a decline of AFP ≤95% experienced post-LT relapse. Among 9 evaluable patients receiving salvage LT, all three patients with any decline of AFP at LT are currently alive in remission, and three of six patients with no response to pre-LT salvage chemotherapy are also alive and in remission. Response to chemotherapy may be a reliable marker for prediction of post-LT relapse, even for patients receiving salvage LT.

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Section: Resultsmentioning

confidence: 99%

“…ICG fluorescence imaging navigation was used to achieve complete removal of pulmonary metastases for patient 9, according to a previous report. 17 (Table 4).…”

Section: Clinical Outcomes Of Patients With Post-lt Relapsementioning

confidence: 99%

Prognostic and therapeutic factors influencing the clinical outcome of hepatoblastoma after liver transplantation: A single‐institute experience

Umeda

Okajima

Kawaguchi

et al. 2018

Pediatric Transplantation

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“…The addition of indocyanine green (ICG) fluorescence has helped address this issue. Lesions as small as 0.062mm can be detected using ICG [28] (Figure 4). In addition to lung lesions, primary and recurrent tumor in the liver have also been accurately detected using ICG [29].…”

Section: Surgical Resectionmentioning

confidence: 99%

Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation

et al. 2018

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The most common primary malignant liver tumor of childhood, hepatoblastoma has increased in incidence over the last 30 years, but little is still known about its pathogenesis. Discoveries in molecular biology provide clues but have yet to define targeted therapies. Disease-free survival varies according to stage, but is greater than 90% in favorable risk populations, in part due to improvements in chemotherapeutic regimens, surgical resection, and earlier referral to liver transplant centers. This article aims to highlight the principles of disease that guide current treatment algorithms. Surgical treatment, especially orthotopic liver transplantation, will also be emphasized in the context of the current Children’s Oncology Group international study of pediatric liver cancer (AHEP-1531).

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“…It is contraindicated in those allergic to iodinated contrasts or with thyroid disorders. 9,[11][12][13][14] The use of fluorescence in surgery is emerging, but experience in splenic pathology is very limited. Kawasaki et al 15 used ICG during distal pancreatectomies with splenic preservation.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Partial Splenectomy Assisted by Fluorescence in a 13-Year-Old Girl

Bada-Bosch

Mata

Torre

et al. 2020

European J Pediatr Surg Rep

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Partial splenectomy allows preserving immune function in benign splenic lesions such as epidermoid cysts. Determining the plane of resection and perfusion of the spleen remnant can be difficult, especially in centrally located lesions. We present a 13-year-old girl with a symptomatic splenic cyst of 6 cm in diameter located next to the splenic hilum. Laparoscopic partial splenectomy was performed through a 10-mm umbilical approach and three accessory 5-mm ports. Intraoperative intravenous injection of indocyanine green (ICG) at 0.2 mg/kg guided the careful dissection of the splenic hilum and checked the spleen perfusion once the upper arterial branch was clamped. The subsequent wash-out of the ICG allowed inspection of the peripheral vascular return of the splenic remnant through polar veins. Surgery was uneventful with minimal blood loss. Follow-up ultrasound scan revealed a well-perfused small splenic remnant with no signs of recurrence.Laparoscopic partial splenectomy is feasible in benign splenic tumors, especially in those cases of peripheral location. Fluorescence facilitates the safe dissection of the splenic hilum, the visualization of the transection plane of the spleen and the perfusion of the remnant in cases of anatomically and technically complicated partial splenectomies.

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Navigation using indocyanine green fluorescence imaging for hepatoblastoma pulmonary metastases surgery

Cited by 67 publications

References 19 publications

Prognostic and therapeutic factors influencing the clinical outcome of hepatoblastoma after liver transplantation: A single‐institute experience

Prognostic and therapeutic factors influencing the clinical outcome of hepatoblastoma after liver transplantation: A single‐institute experience

Hepatoblastoma—The Evolution of Biology, Surgery, and Transplantation

Laparoscopic Partial Splenectomy Assisted by Fluorescence in a 13-Year-Old Girl

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