Nb₂CT_x/Protonated Carbon Nitride Nanocomposite for Electrochemical Detection of Serotonin

Abstract

Serotonin is a principal neurotransmitter that actively takes part in our behavioral as well as biological activities. Hence, its detection plays a vital role in understanding the intricate connections between this neurotransmitter and various physiological processes. Consequently, the development of sensitive and reliable electrochemical sensors for serotonin detection is of paramount importance. In this study, we present a different approach for synthesizing a highly stable composite of Nb2CT x and protonated carbon nitride (Nb2CT x /PCN) utilizing the electrostatic interaction between them. The synthesized Nb2CT x /PCN composite was utilized for the construction of an electrochemical sensor dedicated to serotonin analysis. The developed sensor exhibits remarkable performance, offering enhanced sensitivity, selectivity, and detection limits of 63.24 nM over a concentration range of 1–100 μM for serotonin detection in human serum. A versatile thread-based sensing platform is made to validate the sensor performance. Our findings pave the way for significant advancements in the field of MXene-based composites for neurotransmitter analysis, enabling researchers and clinicians to gain deeper insights into the role of serotonin in human health and diseases.

Biological Metal–Organic Framework-Embedded MXene Nanocomposite as a Wearable Transducer Patch for Real-Time Monitoring of the Sleep Hormone

“…The N–H bending vibration band appeared at 1564 cm –1 , and the Zn–O vibration band was observed at 574 cm –1 . , The IR bands of Nb 2 CT x MXene show a peak at 1649 cm –1 corresponding to the CO band and another peak at 1018 cm –1 corresponding to Nb–O . A broad peak in the range of 3164 cm –1 correspond to the −OH stretching vibration present in Nb 2 CT x MXene, which is narrowed in the Zn-MOF-Nb 2 CT x MXene composite . The bands of Zn-MOF including the N–H bending vibration, Zn–O vibration, stretching vibration of COO-Zn, and stretching vibration of −COOH are observed in the Zn-MOF-Nb 2 CT x MXene composite.…”

“…The IR bands of Zn-MOF at 1405 and 1104 cm –1 are attributed to the stretching vibrations of COO-Zn and −COOH, respectively . The N–H bending vibration band appeared at 1564 cm –1 , and the Zn–O vibration band was observed at 574 cm –1 . , The IR bands of Nb 2 CT x MXene show a peak at 1649 cm –1 corresponding to the CO band and another peak at 1018 cm –1 corresponding to Nb–O . A broad peak in the range of 3164 cm –1 correspond to the −OH stretching vibration present in Nb 2 CT x MXene, which is narrowed in the Zn-MOF-Nb 2 CT x MXene composite .…”

“…54 A broad peak in the range of 3164 cm −1 correspond to the −OH stretching vibration present in Nb 2 CT x MXene, which is narrowed in the Zn-MOF-Nb 2 CT x MXene composite. 54 2d). 55 Additionally, a N peak was not observed on the as-synthesized Nb 2 CT x MXene.…”

“…34,53 The IR bands of Nb 2 CT x MXene show a peak at 1649 cm −1 corresponding to the C�O band and another peak at 1018 cm −1 corresponding to Nb−O. 54 A broad peak in the range of 3164 cm −1 correspond to the −OH stretching vibration present in Nb 2 CT x MXene, which is narrowed in the Zn-MOF-Nb 2 CT x MXene composite. 54 2d).…”