The alignment of Course Outcomes (CO) with Program Outcomes (PO) is pivotal in the National Board of Accreditation (NBA) assessments, ensuring educational programs meet stringent quality standards. This chapter explores the critical role of CO-PO mapping in enhancing educational outcomes by fostering a structured and systematic approach to curriculum design, delivery, and assessment. Through detailed analysis, we examine how CO-PO mapping provides clear guidelines for educators, aligns teaching methodologies with desired competencies, and facilitates continuous improvement in academic programs. By linking course-level objectives with overarching program goals, this process aids in identifying gaps, ensuring compliance with NBA criteria, and promoting accountability. The chapter also discusses the benefits of CO-PO mapping for stakeholders, including students, faculty, and institutions, highlighting its significance in producing graduates equipped with the necessary skills and knowledge to excel in their professional careers.