Ncog-21. Interim Results of Three Cognitive Rehabilitation Strategies in Patients With Lower Grade Gliomas

Taylor, Jennie; Weyer-Jamora, Christina; Brie, Melissa S; Bracci, Paige M.; Smith, Ellen M. Lavoie; Luks, Tracy; Braunstein, Steve; Villanueva‐Meyer, Javier; Gehring, Karin; Aguilera, Adrián; Bush, Nancy Ann Oberheim; Clarke, Jennifer; Butowski, Nicholas; Chang, Susan; Hervey-Jumper, Shawn L.

doi:10.1093/neuonc/noaa215.560

Cited by 2 publications

(13 citation statements)

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“…There were also 7 (20.0%) prospective uncontrolled/pilot studies, and one (2.9%) retrospective case–control study. Three (8.6%) of the identified studies were presented in abstract form, with no full‐text study available at the time this review was conducted 4,11,14 …”

Section: Resultsmentioning

confidence: 99%

“…Of the 21 nonpharmacological studies identified, 11 were randomised 11–15,18,19,21,37–39 and 10 were nonrandomised 16,17,20,22,40–45 . Most of the nonpharmacological studies evaluated cognitive training or rehabilitation programmes 11–18,22,38–41,43,44 . The cognitive rehabilitation was delivered through a range of modalities, including computer programs and virtual reality.…”

Section: Resultsmentioning

confidence: 99%

“…The sample sizes of the nonpharmacological studies included in this review ranged from 3 44 to 143 45 . Five of the 21 studies were multicentre, 12,19,21,38,42 and the remainder were single‐centre studies 11,13–18,20,22,37,39–41,43–45 . Like the pharmacological intervention studies, the mean/median age of participants in the nonpharmacological intervention studies was similar, in the fifth and sixth decades of life, although participant ages were not reported in one study 11 .…”

Section: Resultsmentioning

confidence: 99%

“…16,45 studies did not include a comparator group. In nine of the 21 nonpharmacological intervention studies, preexisting subjective or objective cognitive impairment was a criterion for inclusion in the study [13][14][15]18,20,37,39,40,44 ; hence, these studies evaluated cognitive deficit amelioration (as opposed to prevention). The sample sizes of the nonpharmacological studies included in this review ranged from 3 44 to 143.…”

Section: Nonpharmacological Studiesmentioning

confidence: 99%

“…For example, donepezil, by inhibiting the breakdown of acetylcholine, could prolong and improve cholinergic function, which is associated with learning and memory. 10 Nonpharmacological interventions that have been used in patients with brain tumours are varied and include cognitive rehabilitation, [11][12][13][14][15][16][17] mindfulness training, 18 exercise therapy, 19 hyperbaric oxygen therapy 20 and dietary intervention. 21 Given the wide diversity in nonpharmacological approaches, the potential mechanisms through which these interventions could bring about a change in cognitive function are likely to be equally varied.…”

Section: Introductionmentioning

confidence: 99%

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A systematic review of cognitive interventions for adult patients with brain tumours

et al. 2023

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Background: Neurocognitive impairments are common in patients with current or previously treated brain tumours, and such impairments can negatively affect patient outcomes including quality of life and survival. This systematic review aimed to identify and describe interventions used to ameliorate (improve) or prevent cognitive impairments in adults with brain tumours. Methods: We performed a literature search of the Ovid MEDLINE, PsychINFO and PsycTESTS databases from commencement until September 2021. Results: In total, 9998 articles were identified by the search strategy; an additional 14 articles were identified through other sources. Of these, 35 randomised and nonrandomised studies were deemed to meet the inclusion/exclusion criteria of our review and were subsequently included for evaluation. A range of interventions were associated with positive effects on cognition, including pharmacological agents such as memantine, donepezil, methylphenidate, modafinil, ginkgo biloba and shenqi fuzheng, and nonpharmacological interventions such as general and cognitive rehabilitation, working memory training, Goal Management Training, aerobic exercise, virtual reality training combined with computerassisted cognitive rehabilitation, hyperbaric oxygen therapy and semantic strategy training. However, most identified studies had a number of methodological limitations and were judged to be at moderate-to-high risk of bias. In addition, it remains unclear whether and to what extent the identified interventions lead to durable cognitive benefits after cessation of the intervention. Conclusion: The 35 studies identified in this systematic review have indicated potential cognitive benefits for a number of pharmacological and nonpharmacological interventions in patients with brain tumours. Study limitations were identified and further studies should focus on improved study reporting, methods to reduce bias and minimise participant drop-out and withdrawal where possible, and consider standardisation of methods and interventions across studies. Greater collaboration between centres could result in larger studies with standardised methods and outcome measures, and should be a focus of future research in the field.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Nonpharmacological Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A systematic review of cognitive interventions for adult patients with brain tumours

et al. 2023

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Psychological and neuropsychological clinical impact in brain cancer patients and evidence-based psychological intervention: a systematic review of the literature

Caponnetto,

Schilirò,

Maglia

et al. 2024

Health Psychology Research

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Background Cancer patients may suffer from psychological disorders related to their health condition. Various medical, surgical, and interventional procedures, alongside the distinct tumor localization, have been linked to an elevated predisposition towards psychological disorders, including but not limited to depression, anxiety, post-traumatic stress disorder (PTSD), and cognitive impairments. Objective To systematically review the literature on neurocognitive rehabilitation of patients before and after brain cancer. Methods The systematic review was performed according to the PRISMA 2020 guidelines for the systematic review of the PRISMA Group. The literature search was conducted from February 2022 to December 2022 in the databases of PubMed, APA PsycNet, and Web of Science. The focus was on cognitive-behavioural treatments, with Goal Management Training (GMT), and also an app on the iPad- ReMind- that includes psychoeducation, strategy training, and retraining, and new technologies such as virtual reality, in patients with cognitive deficits after neurosurgery. Conclusions Overall, neurocognitive rehabilitation had an improvement on cancer patients and a recovery of executive and cognitive functions, a better quality of life, and psychological well-being.

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Ncog-21. Interim Results of Three Cognitive Rehabilitation Strategies in Patients With Lower Grade Gliomas

Cited by 2 publications

References 0 publications

A systematic review of cognitive interventions for adult patients with brain tumours

A systematic review of cognitive interventions for adult patients with brain tumours

Psychological and neuropsychological clinical impact in brain cancer patients and evidence-based psychological intervention: a systematic review of the literature

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